Role of the stress response and the endocannabinoid system in Δ9-tetrahydrocannabinol (THC)-induced nausea

DeVuono, Marieka V.; Caprara, Olivia La; Sullivan, Megan T.; Bath, Alexandra; Petrie, Gavin N; Limebeer, Cheryl L.; Rock, Erin M.; Hill, Matthew N.; Parker, Linda A.

doi:10.1007/s00213-020-05529-5

Cited by 12 publications

(13 citation statements)

References 110 publications

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“…injection), where MJN110 was administered 3 h after the last MP injection (posttreatment group). The MJN110 dose used was based on that reported in previous studies 22–24 . The femoral head and long bone samples were harvested at 6 weeks after the establishment of the model.…”

Section: Methodsmentioning

confidence: 99%

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Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid‐induced osteonecrosis of the femoral head

Yang

Sun

Xue

et al. 2021

Clinical & Translational Med

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Section: Methodsmentioning

confidence: 99%

“…Sprague-Dawley (SD) rats (male, age: 10 weeks, weight: 400 [22][23][24] The femoral head and long bone samples were harvested at 6 weeks after the establishment of the model. The Ethics Committee of the First Affiliated Hospital of Soochow University approved all animal experiments.…”

Section: Animal Studiesmentioning

confidence: 99%

Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid‐induced osteonecrosis of the femoral head

Yang

Sun

Xue

et al. 2021

Clinical & Translational Med

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“…Cannabis hyperemesis syndrome (CHS) has emerged recently as a significant risk of chronic cannabis use. CHS is described as a paradoxical side effect of cannabis use (since cannabis has anti-emetic effects), and is characterized by cyclical nausea, vomiting, and abdominal pain with no clear etiology ( 15 ), though is thought to be related to changes in the endocannabinoid system and subsequent dysregulation of stress and anxiety responses ( 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

Cannabis Legalization and Acute Harm From High Potency Cannabis Products: A Narrative Review and Recommendations for Public Health

Matheson

Foll

2020

Front. Psychiatry

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Legalization and commercial sale of non-medical cannabis has led to increasing diversity and potency of cannabis products. Some of the American states that were the first to legalize have seen rises in acute harms associated with cannabis use, e.g. Colorado has seen increases in emergency department visits for cannabis-related acute psychological distress and severe vomiting (hyperemesis), as well as a number of high-profile deaths related to ingestion of high doses of cannabis edibles. Over-ingestion of cannabis is related to multiple factors, including the sale of cannabis products with high levels of THC and consumers’ confusion regarding labelling of cannabis products, which disproportionately impact new or inexperienced users. Based on our review of the literature, we propose three approaches to minimizing acute harms: early restriction of cannabis edibles and high-potency products; clear and consistent labelling that communicates dose/serving size and health risks; and implementation of robust data collection frameworks to monitor harms, broken down by cannabis product type (e.g. dose, potency, route of administration) and consumer characteristics (e.g. age, sex, gender, ethnicity). Ongoing data collection and monitoring of harms in jurisdictions that have existing legal cannabis laws will be vital to understanding the impact of cannabis legalization and maximizing public health benefits.

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“…As another potential explanation for variation in results across the two studies, Mayer et al (2014) induced stress prior to acute THC exposure, which limits further propagation of its activity as a result of negative feedback. A more recent study performed in rats by Devuono et al (2020) provides evidence for a dose-dependent increase in serum corticosterone following the administration of THC.…”

Section: Influence Of Thc On Physiological Glucocorticoid Levels and Sensitivitymentioning

confidence: 93%

Glucocorticoids, Stress and Delta-9 Tetrahydrocannabinol (THC) during Early Embryonic Development

Kuzma-Hunt

Truong

Favetta

2021

IJMS

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Elevated molecular stress in women is known to have negative impacts on the reproductive development of oocytes and the embryos prior to implantation. In recent years, the prevalence of cannabis use among women of reproductive age has risen due to its ability to relieve psychological stress and nausea, which are mediated by its psychoactive component, ∆-9-tetrahydrocannabinol (THC). Although cannabis is the most popular recreational drug of the 21st century, much is unknown about its influence on molecular stress in reproductive tissues. The current literature has demonstrated that THC causes dose- and time-dependent alterations in glucocorticoid signaling, which have the potential to compromise morphology, development, and quality of oocytes and embryos. However, there are inconsistencies across studies regarding the mechanisms for THC-dependent changes in stress hormones and how either compounds may drive or arrest development. Factors such as variability between animal models, physiologically relevant doses, and undiscovered downstream gene targets of both glucocorticoids and THC could account for such inconsistencies. This review evaluates the results of studies which have investigated the effects of glucocorticoids on reproductive development and how THC may alter stress signaling in relevant tissues.

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Role of the stress response and the endocannabinoid system in Δ9-tetrahydrocannabinol (THC)-induced nausea

Cited by 12 publications

References 110 publications

Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid‐induced osteonecrosis of the femoral head

Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid‐induced osteonecrosis of the femoral head

Cannabis Legalization and Acute Harm From High Potency Cannabis Products: A Narrative Review and Recommendations for Public Health

Glucocorticoids, Stress and Delta-9 Tetrahydrocannabinol (THC) during Early Embryonic Development

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