Role of the Stria Vascularis in the Pathogenesis of Sensorineural Hearing Loss: A Narrative Review

Yu, Wei; Zong, Shimin; Du, Peiyu; Zhou, Peng; Li, Hejie; Wang, Enhao; Xiao, Hongjun

doi:10.3389/fnins.2021.774585

Cited by 20 publications

(11 citation statements)

References 114 publications

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“…In previous studies in the experimental model, an oedema in stria vascularis was found [ 43 , 44 ] in mice with hypercholesterolemia [ 45 ]. Nevertheless, although stria vascularis is a well-known site of damage in systemic diseases, the actual underlying pathogenesis is still unknown [ 46 ]. We previously studied common markers shared between HL and ARHL in an experimental model, demonstrating that noise-induced hearing loss can worsen/accelerate redox status imbalance including the increase of reactive oxygen species production; lipid peroxidation; dysregulation of endogenous antioxidant response, vascular dysfunction, such as increased expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in the cochlea, both of which are involved in the dysregulation of redox status and inflammatory pathway activation [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Vascular Factors in Patients with Midlife Sensorineural Hearing Loss and the Progression to Mild Cognitive Impairment

et al. 2023

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Background and Objectives: Midlife hearing loss (HL) has been considered as a major modifiable risk factor for a later-life progression to dementia. Our aim was to detect a link between precocious sensorineural hearing loss (SNHL) and mild cognitive impairment (MCI) and their association to putative risk factors for a common pathology. Materials and methods: In this study, a retrospective case-control study was carried out. A total of 112 patients were enrolled as following: 81 patients with bilateral SNHL and 31 subjects with normal hearing, whose ages ranged from 50 to 65 years. Both groups performed pure tone audiometry, a tinnitus handicap inventory (THI), Mini-Mental State examination (MMSE), and the Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression Scale (HADS-A and HADS-D). Results: The mean age was 58 ± 5.2 in SNHL patients and 53.2 ± 4.8 in the control group. The mean pure tone average in the SNHL group was 40.2 ± 18.7 dB HL on the right side and 41.2 ± 17.2 dB HL on the left side, while in the control group it was 12.5 ± 2.8 dB HL on right side and 12.4 ± 3.1 dB HL on left side. About 64% of patients with SNHL exhibited comorbidities, and the most common condition was hypertension. Altered MoCA test scores were significantly related to the pure tone averages in patients with SNHL compared to the control group (p = 0.0004), while the differences in the HADS-A and HADS-D were not significant. Furthermore, a significant correlation was observed in SNHL patients between an altered MoCA test and hypercholesterolemia (p = 0.043). Conclusions: Hearing impairment and screening tests to detect MCI should be considered in the midlife in order to carry out strategies to prevent the progression to dementia. Hypertension and hypercholesterolemia are two risk factors in the development of endothelial dysfunction, oxidative stress, and vascular inflammation, and may represent the common pathology linking the inner ear and brain damage.

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Section: Discussionmentioning

confidence: 99%

Vascular Factors in Patients with Midlife Sensorineural Hearing Loss and the Progression to Mild Cognitive Impairment

et al. 2023

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“…The slower rate of hair cell death in the nectin-3 KO cochlea might reflect the limited number of attached hair cells. The lateral wall of cochlea (stria vascularis) also contributes to auditory function and maintenance of homeostasis in the cochlear fluid through the generation of endocochlear potential (EP) ( Yu et al, 2021 ). The tight junction formation in the stria vascularis is important for the generation of EP ( Gow et al, 2004 ).…”

Section: Discussionmentioning

confidence: 99%

Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea

Katsunuma

Togashi²,

Kuno³

et al. 2022

Front. Cell Dev. Biol.

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In the cochlear auditory epithelia, sensory hair and supporting cells are arranged in a checkerboard-like mosaic pattern, which is conserved across a wide range of species. The cell adhesion molecules nectin-1 and nectin-3 are required for this pattern formation. The checkerboard-like pattern is thought to be necessary for auditory function, but has never been examined. Here, we showed the significance of checkerboard-like cellular pattern in the survival and function of sensory hair cells in the cochlear auditory epithelia of nectin-3 knockout (KO) mice. Nectin-3 KO mice showed progressive hearing loss associated with degeneration of aberrantly attached hair cells via apoptosis. Apoptotic hair cell death was due to the disorganization of tight junctions between the hair cells. Our study revealed that the checkerboard-like cellular pattern in the auditory epithelium provides a structural basis for ensuring the survival of cochlear hair cells and hearing function.

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“…Kolejnym bardzo poważnym zaburzeniem mogącym występować u osobników z umaszczeniem marmurkowym jest wrodzona głuchota (27), która zwykle rozwija się w ciągu pierwszych kilku tygodni po urodzeniu, gdy przewód słuchowy jest jeszcze zamknięty. Choroba spowodowana jest niedostateczną liczbą funkcjonalnych melanocytów w prążkowiu naczyniowym ślimaka, które są niezbędne do wytwarzania potencjału wewnątrz ślimakowego w uchu wewnętrznym, który umożliwia komórkom rzęskowym przekształcenie wibracji dźwiękowych w potencjał czynnościowy (40). Częstość występowania tego schorzenia u psów-nosicieli allelu M (genotyp heterozygotyczny 305 M/+) szacuje się na 3,5%, a u homozygot (M/M) na 25%.…”

Section: Typ Dziki Intensywna Pigmentacja Brak Wzoru Marmurkowegounclassified

Molecular background of the merle coat color in dogs and its health consequences

SZATKOWSKA¹,

OTRĘBA²,

KORBECKI³

et al. 2023

Medycyna Weterynaryjna

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Coat colour in dogs is influenced by many genes and their polymorphic forms. The main coat colour pattern depends on pigment type, i.e. eumelanin or pheomelanin, whose synthesis is regulated by tyrosinase encoded by the TYRP1 gene. However, other genes also contribute to the ultimate phenotype. One of them is PMEL responsible for the merle coat colour. This review focuses on the role of melanocytes in the phenotypic expression of coat colour, the merle phenotype and genotype, phenotypic diversity of the M allele carriers, health consequences for the carriers of the allele responsible for the merle coat colour and problems with the identification of the M allele carriers based on phenotype and dog breeds with the merle coat colour accepted by the FCI.

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Role of the Stria Vascularis in the Pathogenesis of Sensorineural Hearing Loss: A Narrative Review

Cited by 20 publications

References 114 publications

Vascular Factors in Patients with Midlife Sensorineural Hearing Loss and the Progression to Mild Cognitive Impairment

Vascular Factors in Patients with Midlife Sensorineural Hearing Loss and the Progression to Mild Cognitive Impairment

Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea

Molecular background of the merle coat color in dogs and its health consequences

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