Role of the stromal microenvironment in regulation of medullary hematopoiesis during stress

Dynamic theory of hemopoiesis regulation

“…At present, the phenotype and the main properties of T cells controlling hemopoiesis are well studied [10,[34][35][36][37]45,46,70,105]. T cells activate resident macrophages and stromal mechanocytes in HIM [14,15,40,50,61,122] responsible l-or proliferation and differentiation of hemopoietic precursors from polypotent to mature cells [26,67]. Moreover, hormones produced by adrenal medulla and cortex directly (via receptor-mediated pathways) and indirectly (through T lymphocytes, macrophages, stromal mechanocytes) synchronize and stimulate proliferative and differentiation activities of hemopoietic cells [24,31,33,86,98].…”