Role of the T-Cell Network in Psychiatric Disorders

Debnath, Monojit; Maes, Michael; Berk, Michael

doi:10.1007/978-3-030-71229-7_7

Cited by 2 publications

(1 citation statement)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the last decade, evidence has been accumulating on a disrupted function of the T cell system in BD. T lymphocytes are well known as regulators of inflammation, but also play an important role in key brain processes ( Debnath et al, 2021 ). Previous studies have shown higher frequencies of circulating activated T cells as well as increased p-ERK signaling in T cells of patients with BD ( Barbosa et al, 2014 ; Breunis et al, 2003 ; Do Prado et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Higher T central and lower effector memory cells in bipolar disorder: A differentiation abnormality?

Ioannou,

Simon,

Borkent

et al. 2024

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Higher T central and lower effector memory cells in bipolar disorder: A differentiation abnormality?

Ioannou,

Simon,

Borkent

et al. 2024

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

Causal role of immune cells in bipolar disorder: a Mendelian randomization study

Wang,

Yuan

et al. 2024

Front. Psychiatry

View full text Add to dashboard Cite

BackgroundThe understanding of the immunological mechanisms underlying bipolar disorder (BD) has enhanced in recent years due to the extensive use of high-density genetic markers for genotyping and advancements in genome-wide association studies (GWAS). However, studies on the relationship between immune cells and the risk of BD remain limited, necessitating further investigation.MethodsBidirectional two-sample Mendelian Randomization (MR) analysis was employed to investigate the causal association between immune cell morphologies and bipolar disorder. Immune cell traits were collected from a research cohort in Sardinia, whereas the GWAS summary statistics for BD were obtained from the Psychiatric Genomics Consortium. Sensitivity analyses were conducted, and the combination of MR-Egger and MR-Presso was used to assess horizontal pleiotropy. Cochran’s Q test was employed to evaluate heterogeneity, and the results were adjusted for false discovery rate (FDR).ResultsThe study identified six immune cell phenotypes significantly associated with BD incidence (P< 0.01). These phenotypes include IgD- CD27- %lymphocyte, CD33br HLA DR+ CD14- AC, CD8 on CD28+ CD45RA+ CD8br, CD33br HLA DR+ AC, CD14 on CD14+ CD16+ monocyte, and HVEM on CD45RA- CD4+. After adjusting the FDR to 0.2, two immune cell phenotypes remained statistically significant: IgD-CD27-% lymphocyte (OR=1.099, 95% CI: 1.051-1.149, P = 3.51E-05, FDR=0.026) and CD33br HLA DR+ CD14-AC (OR=0.981, 95% CI: 0.971-0.991, P = 2.17E-04, FDR=0.079). In the reverse MR analysis, BD significantly impacted the phenotypes of four monocytes (P< 0.01), including CD64 on CD14+ CD16+ monocyte, CD64 on monocyte, CX3CR1 on CD14- CD16-, CD64 on CD14+ CD16- monocyte. However, after applying the FDR correction (FDR < 0.2), no statistically significant results were observed.ConclusionsThis MR investigation reveals associations between immune cell phenotypes, bipolar disorder, and genetics, providing novel perspectives on prospective therapeutic targets for bipolar disorder.

show abstract

Role of the T-Cell Network in Psychiatric Disorders

Cited by 2 publications

References 110 publications

Higher T central and lower effector memory cells in bipolar disorder: A differentiation abnormality?

Higher T central and lower effector memory cells in bipolar disorder: A differentiation abnormality?

Causal role of immune cells in bipolar disorder: a Mendelian randomization study

Contact Info

Product

Resources

About