Role of the tachykinin NK1 receptor in mediating contraction to 5-hydroxytryptamine and antigen in the mouse trachea

Swert, Katelijne O. De; Lefebvre, Romain; Pauwels, Romain; Joos, Guy

doi:10.1016/j.pupt.2006.06.005

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Previous work demonstrated that serotonin is able to induce a concentration dependent bronchoconstriction in rodents (De Swert et al 2007). The existence of serotonin receptors in airway smooth muscles of these animals is proven.…”

Section: Discussionmentioning

confidence: 97%

Study on bronchoconstriction induced by histamine or serotonin in “Precision Cut Lung Slices” of the horse

Barton¹,

Wabnitz²,

Kietzmann³

et al. 2013

PHK

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SummaryThe aim of this study was to determine the effect of histamine and serotonin, as well as the influence of their inhibitors, on bronchoconstriction using equine precision-cut lung slices (PCLS), which were prepared from 5 horses affected by various degrees of small airway disease (SAD) and a sixth horse free of respiratory disease. Over all horses, histamine caused a concentration-dependent bronchoconstriction, with a median effective concentration of 1820 nM. The histamine induced bronchoconstriction could be inhibited by incubation with the H1-receptor antagonist cetirizine before the addition of histamine. However, incubation with the H2-receptor-antagonist ranitidine, the H2 and H3-receptor antagonist thioperamid and the H4-receptor antagonist JNJ7777120 had no significant effect. Serotonin induced a concentration-dependent bronchoconstriction in the horse without evidence of airway disease only. The serotonin-induced reaction in this case was inhibited when the PCLS was previously incubated in ketanserin. The possibility that respiratory disease could have a negative effect on the serotonin-receptor or the serotonin-induced bronchoconstriction pathway is discussed.Keywords: Bronchoconstriction / histamine / serotonin / PCLS / horse / pulmology / chronic airway disease Untersuchung der durch Histamin oder Serotonin induzierten Bronchokonstriktion in "Precision Cut Lung Slices" des Pferdes Das Ziel der Studie lag in der Untersuchung des Effektes von Histamin und Serotonin sowie des Einflusses ihrer Inhibitoren auf die

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Section: Discussionmentioning

confidence: 97%

Study on bronchoconstriction induced by histamine or serotonin in “Precision Cut Lung Slices” of the horse

Barton¹,

Wabnitz²,

Kietzmann³

et al. 2013

PHK

View full text Add to dashboard Cite

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Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice

Dupont

Bracke

Maeyer

et al. 2014

Pulmonary Pharmacology & Therapeutics

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The effect of cannabinoids on dinitrofluorobenzene-induced experimental asthma in mice

Bozkurt

Kaya

Durlu-Kandilci

et al. 2016

Respiratory Physiology & Neurobiology

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Role of the tachykinin NK1 receptor in mediating contraction to 5-hydroxytryptamine and antigen in the mouse trachea

Abstract: antagonists SR140333 and RP67580 had no effect on 5-hydroxytryptamine-induced contractions. In conclusion, the 5-hydroxytryptamine-induced tracheal contraction includes a cholinergic mechanism that requires the presence of the tachykinin NK 1 receptor.

Cited by 3 publications

References 36 publications

Study on bronchoconstriction induced by histamine or serotonin in “Precision Cut Lung Slices” of the horse

Study on bronchoconstriction induced by histamine or serotonin in “Precision Cut Lung Slices” of the horse

Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice

The effect of cannabinoids on dinitrofluorobenzene-induced experimental asthma in mice

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