Role of the thymus in induction and transfer of vaccination against adjuvant arthritis with a T lymphocyte line in rats.

Holoshitz, Joseph; Matitiau, A; Cohen, Irun R.

doi:10.1172/jci111722

Cited by 20 publications

(9 citation statements)

References 15 publications

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“…Several lines of evidence have shown the importance of T lymphocytes in the pathogenesis of rheumatoid arthritis using animal models of arthritis 35–40 . The data also suggest that both regulatory and pathogenic T lymphocytes might be involved 41–45 .…”

Section: Discussionmentioning

confidence: 87%

Increased activation‐induced cell death in peripheral lymphocytes of rheumatoid arthritis patients: the mechanism of action

Tang¹,

Yocum²,

Dejonghe³

et al. 2004

Immunology

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SUMMARYRecently, we have described a soluble survival signal for activated lymphocytes from CD14 + cells. As a result of the importance of T lymphocytes in the pathogenesis of rheumatoid arthritis (RA), we speculate a possible role for CD14 + cells in supporting the outgrowth of autoreactive lymphocytes in RA. To address this issue further, supernatants from activated CD14 + cells (CD14 cocktails) in both normal controls and RA patients were collected. The relative strength of the CD14 cocktails from normal controls and RA patients was compared. The data showed that depletion of CD14 + cells resulted in a much higher increase of activation-induced cell death (AICD) and a decrease of lymphocyte proliferation in the peripheral blood mononuclear cells of RA patients compared to normal controls. Interestingly, CD14 cocktails from RA patients provide much stronger protection against AICD compared to those from normal controls. The observed soluble survival signal from CD14 + cells is a general phenomenon because CD14 cocktails prevent both phytohaemagglutinin A-p-and anti-CD3-induced AICD. Furthermore, supernatants collected from human dendritic cell cultures also prevent activated lymphocytes from undergoing AICD. The data implicate an important role of the CD14 + cell and its secreted form of survival signal in the pathogenesis of RA.

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Section: Discussionmentioning

confidence: 87%

Increased activation‐induced cell death in peripheral lymphocytes of rheumatoid arthritis patients: the mechanism of action

Tang¹,

Yocum²,

Dejonghe³

et al. 2004

Immunology

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“…Interestingly, only activated T cells were effective in vaccination. The resistance to the disease could be transferred to other animals by T cells from vaccinated animals that were raised against the immunizing clones (Holoshitz et al, 1985). Experiments in EAE further demonstrated that T cell vaccination induces or augments the regulatory networks to specifically suppress the eliciting autoreactive T cells (Lider et al, 1988).…”

Section: T Cell Vaccination In Ms Design Of the Study And Vaccine Devmentioning

confidence: 99%

Vaccination with autoreactive T cell clones in multiple sclerosis: overview of immunological and clinical data

Stinissen¹,

Zhang²,

Medaer³

et al. 1996

J. Neurosci. Res.

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“…Animal models of RA have attempted to recapitulate key elements of RA, although none has done so with complete fidelity. For example, in experimental models the transfer of regulatory cells can prevent arthritis [52], while the depletion of said cells results in accelerated disease [53]. On the basis of the link between immune regulation and remission of RA pathology, we decided to explore the use of LF as an immune modulator in this system.…”

Section: Discussionmentioning

confidence: 99%

Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine

Popov

Zheng

et al. 2006

Arthritis Res Ther

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Conventional treatments for autoimmune diseases have relied heavily on nonspecific immune suppressants, which possess a variety of adverse effects without inhibiting the autoimmune process in a specific manner. In the present study we demonstrate the effectiveness of antigen-specific, maturationresistant, tolerogenic dendritic cells (DC) in suppressing collagen-induced arthritis, a murine model of rheumatoid arthritis. Treatment of DC progenitors with the NF-κB inhibiting agent LF 15-0195 (LF) resulted in a population of tolerogenic DC that are characterized by low expression of MHC class II, CD40, and CD86 molecules, as well as by poor allostimulatory capacity in a mixed leukocyte reaction. Administering LF-treated DC pulsed with keyhole limpet hemocyanin antigen to naïve mice resulted hyporesponsiveness specific for this antigen. Furthermore, administration of LF-treated DC to mice with collagen-induced arthritis resulted in an improved clinical score, in an inhibited antigen-specific T-cell response, and in reduced antibody response to the collagen. The efficacy of LF-treated DC in preventing arthritis was substantiated by histological examination, which revealed a significant decrease in inflammatory cell infiltration in the joints. In conclusion, we demonstrate that in vitro-generated antigen-specific immature DC may have important potential as a tolerogenic vaccine for the treatment of autoimmune arthritis.

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Role of the thymus in induction and transfer of vaccination against adjuvant arthritis with a T lymphocyte line in rats.

Cited by 20 publications

References 15 publications

Increased activation‐induced cell death in peripheral lymphocytes of rheumatoid arthritis patients: the mechanism of action

Increased activation‐induced cell death in peripheral lymphocytes of rheumatoid arthritis patients: the mechanism of action

Vaccination with autoreactive T cell clones in multiple sclerosis: overview of immunological and clinical data

Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine

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