Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice

Libarino-Santos, Matheus; Santos, Ana Catherine Gomes de Santana; Cata-Preta, Elisângela G.; Barros-Santos, Thaísa; Brandão, Nina R.N.; Borges, Aurea Lorena Nunes; Santos-Baldaia, Renan; Hollais, A.W.; Baldaia, M.A.; Berro, Laís F.; Marinho, E.A.V.; Frussa‐Filho, Roberto; Oliveira-Lima, Alexandre J.

doi:10.1016/j.drugalcdep.2020.107856

Cited by 8 publications

(5 citation statements)

References 43 publications

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“…According to Lessov and Phillips (12), repeated ethanol administration associated with the test apparatus can promote modifications in neural pathways that mediate locomotor activity so that these pathways become more sensitive and responsive to a subsequent ethanol challenge. In fact, previous studies from our group have also shown that a drug-free interval is necessary for the expression of ethanol-induced behavioral sensitization (13). These neuroadaptations would explain the expression of behavioral sensitization after a drug-free period following a sensitization protocol and zolpidem treatment, and suggest that zolpidem might be modulating or further contributing to ethanol-induced neuroadaptations.…”

Section: Discussionmentioning

confidence: 51%

Treatment with zolpidem after ethanol administration potentiates the expression of ethanol-induced behavioral sensitization in mice

Brandão

Libarino-Santos

Marinho

et al. 2020

Braz J Med Biol Res

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Contradictory findings suggest that the behavioral and abuse-related effects of ethanol are mediated by its action at a1 subunitcontaining GABA A (a1GABA A) receptors. In the present study, we investigated the effects of a sub-chronic post-ethanol administration treatment with zolpidem, an a1-preferring positive allosteric modulator at GABA A receptors, on the subsequent expression of ethanol-induced behavioral sensitization in mice. Animals received ethanol (1.8 g/kg, ip) or saline treatments every other day for 15 days (8 treatment sessions) and were subsequently treated with zolpidem (0.5 mg/kg, ip) or vehicle 4 times on alternate days. At the end of the treatment phase, animals were challenged with saline or ethanol on separate days for the evaluation of the expression of conditioned locomotion and behavioral sensitization. Eight-day treatment with ethanol did not lead to the development of ethanol-induced behavioral sensitization. Animals treated with ethanol and subsequently administered vehicle showed similar locomotion frequencies during the last ethanol challenge compared to the control group receiving ethanol for the first time. Animals treated with ethanol and subsequently administered zolpidem expressed behavioral sensitization to ethanol during the ethanol challenge. The present study adds to the literature by providing further evidence of a role of a1GABA A receptors on the behavioral effects of ethanol. Because of the current highly prevalent co-abuse of ethanol and benzodiazepine drugs in humans, the use of zolpidem and other a1GABA A receptor ligands during ethanol withdrawal should be monitored carefully.

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Section: Discussionmentioning

confidence: 51%

Treatment with zolpidem after ethanol administration potentiates the expression of ethanol-induced behavioral sensitization in mice

Brandão

Libarino-Santos

Marinho

et al. 2020

Braz J Med Biol Res

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“…Researchers employed this measure as a physical indication of ethanol sensitization (Libarino‐Santos et al., 2020 ). The preference apparatus was constructed of wood and had two equal‐sized square bases (15 × 15 × 30 cm).…”

Section: Methodsmentioning

confidence: 99%

Maternal nicotine intoxication before pregnancy induces depressive‐ and anxiety‐like behaviors as well as cognitive deficits in male offspring and correlates with neurobiological changes

Deng

Wang

2023

Brain and Behavior

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Introduction Maternal nicotine use has been suggested to affect the behavior of children and is linked to changes in neurological systems; however, the specific mechanism is yet to be understood. Methods Mice were used to establish a maternal nicotine intoxication model. At postnatal day 60 (adolescent stage), male offspring were tested for behavioral tasks including sucrose preference, open field, elevated plus maze, light/dark box, object recognition, Morris water maze (MWM), and forced swimming. Enzyme‐linked immunoassays were used to measure plasma concentrations of neurotransmitters including norepinephrine, dopamine, serotonin, and corticosterone. Serotonin transporter (Sert), brain‐derived neurotrophic factor (Bdnf), cAMP response element binding protein (Creb), and phosphorylated (p)Creb mRNA levels were measured using quantitative real‐time polymerase chain reaction. Results Male offspring of nicotine‐intoxicated dams had significantly reduced sucrose preference, mobility time in the forced swimming test, and locomotor and exploratory activities. Offspring in the maternal nicotine intoxication group showed increased signs of depressive‐ and anxiety‐like behavior. Recognition memory in the MWM was compromised in these animals. The hippocampal and prefrontal cortical regions showed significant changes in Bdnf, pCreb, and Sert gene expression, whereas CREB mRNA levels were unaffected. Moreover, compared to the controls, neurogenesis and neuronal viability were also reduced in these animals. Conclusion Prenatal nicotine exposure might affect the hypothalamic–pituitary–adrenal axis and reduce neurogenesis, potentially leading to depressive‐like behaviors and cognitive deficiencies in male offspring.

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“…IBO e Veh solutions were administrated orally (gavage). The dose of ethanol was chosen based on previous studies in our laboratory using the CPP paradigm ( Silva et al, 2017 ; Cata-Preta et al, 2018 ; Libarino-Santos et al, 2020 ). The doses of IBO were chosen based on previous rodent studies investigating its effects on ethanol self-administration ( Rezvani et al, 1995 ; He et al, 2005 ).…”

Section: Methodsmentioning

confidence: 99%

“…Total distance traveled in the CPP apparatus also was measured during tests. The CPP design including a treatment phase, post-treatment test, alcohol re-exposure and post-re-exposure (reinstatement) test has been used in our laboratory for several years, with reliable results ( Silva et al, 2017 ; Cata-Preta et al, 2018 ; Reis et al, 2020 ; Libarino-Santos et al, 2020 ; Libarino-Santos et al, 2021 ). This protocol (including the choice of ethanol dose) has been used in our laboratory for several years, and has been shown to reliably induce CPP in mice, allow enough time for extinction and be sensitive to reinstatement upon an ethanol re-exposure, while allowing for treatment manipulations during extinction.…”

Section: Methodsmentioning

confidence: 99%

Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice

et al. 2021

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Ibogaine is a psychedelic extracted from the plant Tabernanthe iboga Baill. (Apocynaceae), natural from Africa, and has been proposed as a potential treatment for substance use disorders. In animal models, ibogaine reduces ethanol self-administration. However, no study to date has investigated the effects of ibogaine on ethanol-induced conditioned place preference (CPP). The present study aimed to investigate the effects of repeated treatment with ibogaine on the reinstatement of CPP to ethanol in male mice. The rewarding effects of ethanol (1.8 g/kg, i. p.) or ibogaine (10 or 30 mg/kg, p. o.) were investigated using the CPP model. Furthermore, we evaluated the effects of repeated treatment with ibogaine (10 or 30 mg/kg, p. o.) on the reinstatement of ethanol-induced CPP. Reinstatement was evaluated under two conditions: 1) during a priming injection re-exposure test in which animals received a priming injection of ethanol and had free access to the CPP apparatus; 2) during a drug-free test conducted 24 h after a context-paired re-exposure, in which subjects received an injection of ethanol and were confined to the compartment previously conditioned to ethanol. Our results show that ethanol, but not ibogaine, induced CPP in mice. Treatment with ibogaine after conditioning with ethanol blocked the reinstatement of ethanol-induced CPP, both during a drug priming reinstatement test and during a drug-free test conducted after re-exposure to ethanol in the ethanol-paired compartment. Our findings add to the literature suggesting that psychedelics, in particular ibogaine, may have therapeutic properties for the treatment of alcohol use disorder at doses that do not have rewarding effects per se.

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Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice

Cited by 8 publications

References 43 publications

Treatment with zolpidem after ethanol administration potentiates the expression of ethanol-induced behavioral sensitization in mice

Treatment with zolpidem after ethanol administration potentiates the expression of ethanol-induced behavioral sensitization in mice

Maternal nicotine intoxication before pregnancy induces depressive‐ and anxiety‐like behaviors as well as cognitive deficits in male offspring and correlates with neurobiological changes

Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice

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