2009
DOI: 10.1002/art.24938
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Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case–control sample sets

Abstract: Objective. To examine the role of genetic variation in the renal urate transporter SLC2A9 in gout in New Zealand sample sets of Māori, Pacific Island, and Caucasian ancestry and to determine if the Māori and Pacific Island samples could be useful for fine-mapping.Methods. Patients (n‫؍‬ 56 Māori, 69 Pacific Island, and 131 Caucasian) were recruited from rheumatology outpatient clinics and satisfied the American College of Rheumatology criteria for gout. The control samples comprised 125 Māori subjects, 41 Paci… Show more

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Cited by 107 publications
(87 citation statements)
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“…23 Due to genetic factors, Māori and Pacific Island patients have a predisposition towards poor excretion of uric acid, and knowledge of this may help destigmatise gout in this group. 1 Genetic risk was not mentioned by our interviewees as a barrier to optimal gout treatment, highlighting the importance of improving and supporting cultural competence among clinicians to overcome perceived cultural barriers. Through this lens, clinicians are responsible for knowing their own culture, and differences between their culture and their patients'.…”
Section: Original Scientific Paper Original Researchmentioning
confidence: 77%
See 1 more Smart Citation
“…23 Due to genetic factors, Māori and Pacific Island patients have a predisposition towards poor excretion of uric acid, and knowledge of this may help destigmatise gout in this group. 1 Genetic risk was not mentioned by our interviewees as a barrier to optimal gout treatment, highlighting the importance of improving and supporting cultural competence among clinicians to overcome perceived cultural barriers. Through this lens, clinicians are responsible for knowing their own culture, and differences between their culture and their patients'.…”
Section: Original Scientific Paper Original Researchmentioning
confidence: 77%
“…In New Zealand (NZ), many Māori and Pacific Island men have a genetic predisposition to gout and experience more severe and debilitating disease. [1][2][3] The most recent epidemiological data show that gout prevalence in Māori and Pacific Island males aged 65 years is more than 30%. 4 Acute gout attacks are self-limiting and can be treated with non-steroidal anti-inflammatories (NSAIDs) colchicine or prednisone.…”
Section: Introductionmentioning
confidence: 99%
“…Historical research (Gosling et al, 2014b) combined with palaeopathological identification of diagnostic lesions (Buckley, 2011;Buckley, 2007;Snow, 1974) has established a deep time-depth for these conditions. It has therefore been proposed that the high rates of disease in modern populations may be a result of ancestry and an inherited genetic predisposition to disease (Hollis-Moffatt et al, 2009;Phipps-Green et al, 2010). These findings have been valuable in initiating discussions with communities about this disease burden and promoting education through community initiatives such as the Māori Gout Action Group (Winnard et al, 2008).…”
Section: Modern-day Health and Links To Evidence Of Disease In The Pastmentioning
confidence: 99%
“…A polymorphism of this gene has been associated with under-excretion of uric acid and hyperuricemia in German Caucasians [10] and a mutation in the gene coding for URAT-1 has been shown to be protective for development of gout in a Japanese cohort [11]. Furthermore, an association of SLC2A9 [12] with gout has been demonstrated in samples of Maori population.…”
Section: Geneticsmentioning
confidence: 99%