Role of the α1-, and α2- and β-adrenoceptors of the median preoptic area on the water intake, renal excretion, and arterial pressure induced by ANG II

Silva, Renata Kelli Pereira da; Menani, José Vanderlei; Saad, Wilson Abrão; Renzi, Antonio; Silveira, Jen; Luiz, A. C.; Camargo, Luiz Antônio de Arruda

doi:10.1016/0006-8993(95)01553-1

Cited by 22 publications

(1 citation statement)

References 26 publications

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“…β-Adrenoceptor agonists stimulate water intake through activation of the renin-angiotensin system [20,23). In addition, β-adrenoceptors play a role in the dipsogenic effect of angiotensin II in the preoptic area and hypothalamus [3,8]. However, our data obtained with propranolol rule out any implication of β-adrenoceptors in the increased nocturnal consumption of water exhibited by Y2−/− and Y4−/− mice.…”

Section: Discussionmentioning

confidence: 67%

Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice

Wultsch

Painsipp

Donner

et al. 2006

Behavioural Brain Research

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Neuropeptide-Y (NPY) is involved in the regulation of ingestive behaviour and energy homeostasis. Since deletion of the NPY Y2 and Y4 receptor gene increases and decreases food intake, respectively, we examined whether water intake during the light and dark phase is altered in Y2 and Y4 receptor knockout mice. The water consumption of mice staying in their home cages was measured by weighing the water bottles at the beginning and end of the light phase during 4 consecutive days. Control, Y2 and Y4 receptor knockout mice did not differ in their water intake during the light phase. However, during the dark phase Y2 and Y4 receptor knockout mice drank significantly more (46-63 %, P<0.05) water than the control mice. The total daily water intake over 24 h was also enhanced. The enhanced water intake during the dark phase was not altered by the β-adrenoceptor antagonist propranolol or the angiotensin AT1 receptor antagonist telmisartan (each injected intraperitoneally at 10 mg/kg). These data indicate that NPY acting via Y2 and Y4 receptors plays a distinctive role in the regulation of nocturnal water consumption. While β-adrenoceptors and angiotensin AT1 receptors do not seem to be involved, water intake in Y2 and Y4 receptor knockout mice may be enhanced because presynaptic autoinhibition of NPY release and inhibition of orexin neurons in the central nervous system are prevented.

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Section: Discussionmentioning

confidence: 67%

Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice

Wultsch

Painsipp

Donner

et al. 2006

Behavioural Brain Research

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Neuroendocrine Regulation of Hydromineral Homeostasis

Mecawi

Ruginsk

Elias

et al. 2015

Comprehensive Physiology

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Since the crucial evolutionary change from an aqueous to a terrestrial environment, all living organisms address the primordial task of equilibrating the ingestion/production of water and electrolytes (primarily sodium) with their excretion. In mammals, the final route for the excretion of these elements is mainly through the kidneys, which can eliminate concentrated or diluted urine according to the requirements. Despite their primary role in homeostasis, the kidneys are not able to recover water and solutes lost through other systems. Therefore, the selective stimulation or inhibition of motivational and locomotor behavior becomes essential to initiate the search and acquisition of water and/or sodium from the environment. Indeed, imbalances affecting the osmolality and volume of body fluids are dramatic challenges to the maintenance of hydromineral homeostasis. In addition to behavioral changes, which are integrated in the central nervous system, most of the systemic responses recruited to restore hydroelectrolytic balance are accomplished by coordinated actions of the cardiovascular, autonomic and endocrine systems, which determine the appropriate renal responses. The activation of sequential and redundant mechanisms (involving local and systemic factors) produces accurate and self-limited effector responses. From a physiological point of view, understanding the mechanisms underlying water and sodium balance is intriguing and of great interest for the biomedical sciences. Therefore, the present review will address the biophysical, evolutionary and historical perspectives concerning the integrative neuroendocrine control of hydromineral balance, focusing on the major neural and endocrine systems implicated in the control of water and sodium balance.

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GABA-mediated attenuation of noradrenaline release in the rat median preoptic area caused by intravenous injection of metaraminol

Sakamaki

Nomura

Yamato

et al. 2004

Autonomic Neuroscience

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Role of the α1-, and α2- and β-adrenoceptors of the median preoptic area on the water intake, renal excretion, and arterial pressure induced by ANG II

Cited by 22 publications

References 26 publications

Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice

Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice

Neuroendocrine Regulation of Hydromineral Homeostasis

GABA-mediated attenuation of noradrenaline release in the rat median preoptic area caused by intravenous injection of metaraminol

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