Role of thyroid dysimmunity and thyroid hormones in endometriosis

Peyneau, Marine; Kavian, Niloufar; Chouzenoux, Sandrine; Nicco, Carole; Jeljeli, Mohamed; Toullec, Laurie; Chenevier‐Gobeaux, Camille; Reis, Fernando M.; Santulli, Piétro; Doridot, Ludivine; Chapron, Charles; Batteux, Frédéric

doi:10.1073/pnas.1820469116

Cited by 29 publications

(28 citation statements)

References 45 publications

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“…We have found increased serum T3 levels with the progressions of endometriosis from stage 1 to stage 4. Similar to our finding, it has been reported that (Peyneau et al, 2019) that thyroid disorders are associated with severe forms of endometriosis. They found that proteins involved in thyroid metabolism were dysregulated in eutopic and ectopic endometrium of endometriotic patients, leading to resistance of ectopic endometrium T3 action (Peyneau et al, 2019).…”

Section: Resultssupporting

confidence: 93%

“…Similar to our finding, it has been reported that (Peyneau et al, 2019) that thyroid disorders are associated with severe forms of endometriosis. They found that proteins involved in thyroid metabolism were dysregulated in eutopic and ectopic endometrium of endometriotic patients, leading to resistance of ectopic endometrium T3 action (Peyneau et al, 2019). However, few others (Parasar et al, 2017) found that women suffering from endometriosis had higher rates of hypothyroidism.…”

Section: Resultssupporting

confidence: 93%

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Elevated Levels of CA-125, Estradiol and Cortisol as Prominent Markers to Diagnose Various Stages of Endometriosis

Ashish¹,

Kusum²,

Rai³

et al. 2021

JSR

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Endometriosis is a chronic inflammatory disease condition that affects an estimated 176 million women worldwide. The disease causes unbearable symptoms of pelvic pain and infertility that limits the quality of reproductive life of affected women. An attempt has been made to identify certain physiological and hormonal factors that may behave as reliable diagnostic markers to assess the various stages of endometriosis. It is a retrospective population-based study. Here a questionnaire-based study was conducted on females of Eastern Uttar Pradesh and Bihar that were suffering from endometriosis. Prevalent patients were characterized in terms of their socio-demographic and clinical characteristics, including the validated infertility and chronic disease registries. Progression of the disease was not found to be affected by age and body mass index (BMI) of subjects. Concentration of blood sugar (fasting and PP), and levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), T4 and Thyroid stimulating hormone (TSH) did not change as disease progressed from stage 1 to 4. However, levels of serum estradiol, cortisol, prolactin, T3 and CA-125 increased as endometriosis progressed. There also existed a close association between CA-125, estradiol, cortisol and stages of endometriosis. Elevated levels of CA-125, estradiol and cortisol may behave as prominent diagnostic markers to assess progression of disease and to discriminate between various stages of endometriosis.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 93%

Elevated Levels of CA-125, Estradiol and Cortisol as Prominent Markers to Diagnose Various Stages of Endometriosis

Ashish¹,

Kusum²,

Rai³

et al. 2021

JSR

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“…Tissue samples have been sutured with 4-0 nylon suture (Cummings and Metcalf, 1995), 7-0 polypropylene suture (Cohen et al, 2014), silk suture (Fainaru et al, 2008), braided silk suture (Efstathiou et al, 2005;Becker et al, 2008), or stuck to the wall with adhesive such as bonding agent 3M vetbond (Symons et al, 2020). Uterine tissue engrafted varied from one large (5 mm) piece (Peyneau et al, 2019) to up to six (2 mm) tissue punches (Kumar et al, 2014). Tissue was sutured or adhered to the peritoneum (Wilkosz et al, 2011;Mattos et al, 2019;Tal et al, 2019;Chang et al, 2020;Hattori et al, 2020;Li et al, 2020;Symons et al, 2020;Yoshino et al, 2020;Chen et al, 2021;Santorelli et al, 2021), intestinal mesentery (Mishra et al, 2020), abdominal wall (Peyneau et al, 2019), bowel mesentery (Ricci et al, 2011), and ovaries (Hayashi et al, 2020).…”

Section: Surgical Engraftmentmentioning

confidence: 99%

Endometriosis in the Mouse: Challenges and Progress Toward a ‘Best Fit’ Murine Model

et al. 2022

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Endometriosis is a prevalent gynecologic condition associated with pelvic pain and infertility characterized by the implantation and growth of endometrial tissue displaced into the pelvis via retrograde menstruation. The mouse is a molecularly well-annotated and cost-efficient species for modeling human disease in the therapeutic discovery pipeline. However, as a non-menstrual species with a closed tubo-ovarian junction, the mouse poses inherent challenges as a preclinical model for endometriosis research. Over the past three decades, numerous murine models of endometriosis have been described with varying degrees of fidelity in recapitulating the essential pathophysiologic features of the human disease. We conducted a search of the peer-reviewed literature to identify publications describing preclinical research using a murine model of endometriosis. Each model was reviewed according to a panel of ideal model parameters founded on the current understanding of endometriosis pathophysiology. Evaluated parameters included method of transplantation, cycle phase and type of tissue transplanted, recipient immune/ovarian status, iterative schedule of transplantation, and option for longitudinal lesion assessment. Though challenges remain, more recent models have incorporated innovative technical approaches such as in vivo fluorescence imaging and novel hormonal preparations to overcome the unique challenges posed by murine anatomy and physiology. These models offer significant advantages in lesion development and readout toward a high-fidelity mouse model for translational research in endometriosis.

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“…Oestrogen promotes the transplantation of endometrial tissue into the peritoneum, thereby affecting proliferation and immortalisation, and also causes local and systematic in ammation [8,11]. Of the in ammatory factors, it has been reported that autoimmunity plays a major role in the development of endometriosis, and the relationship between thyroid autoimmunity and endometriosis has been highlighted [12,13].…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Bone Mineral Density and Ovarian Function in Perimenopausal Women With Endometriosis: A Prospective Study

Uehara

Wada‐Hiraike

Hirano

et al. 2021

Preprint

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Background In women with endometriosis, the association between ovarian function, hormones, and bone mineral density (BMD) is unclear. Therefore, this study aimed to elucidate the correlation between changes in bone mineral density (BMD) in perimenopausal women with endometriosis and clinical data, such as ovarian reserves. Methods In this prospective study, we evaluated 207 female patients who visited the Department of Obstetrics and Gynecology at the University of Tokyo Hospital between December 2015 and December 2020. We included patients aged ≥ 40 years with a history of endometriosis or who presented with endometriosis lesions. Patients with a history of smoking, steroid administration, autoimmune diseases, dyslipidaemia, and heart disease were excluded. During the study period, patients who underwent two tests, an initial and a follow-up test (n = 142, average age: 45.02 years, average BMD: 1.16 g/cm2), were evaluated at regular intervals based on the annual rate of change in BMD. Results There was a negative correlation between the follicle-stimulating hormone (FSH) and BMD, and a positive correlation between the anti-Müllerian hormone (AMH) and BMD. The annual rate of change in BMD correlated only with thyroid-stimulating hormone (TSH) levels. A large decline in BMD was associated with high TSH levels and higher average age at menopause. Patients with higher TSH exhibited a higher rate of decrease in BMD than those without. Conclusions High FSH or low AMH levels are associated with decreased BMD. Decreased ovarian reserve is associated with decreased BMD in perimenopausal women with endometriosis. High TSH levels increase the risk of BMD loss. This finding may help manage osteoporosis and BMD loss in perimenopausal women with endometriosis by predicting BMD loss from ovarian reserve and TSH levels.

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Role of thyroid dysimmunity and thyroid hormones in endometriosis

Cited by 29 publications

References 45 publications

Elevated Levels of CA-125, Estradiol and Cortisol as Prominent Markers to Diagnose Various Stages of Endometriosis

Elevated Levels of CA-125, Estradiol and Cortisol as Prominent Markers to Diagnose Various Stages of Endometriosis

Endometriosis in the Mouse: Challenges and Progress Toward a ‘Best Fit’ Murine Model

Relationship Between Bone Mineral Density and Ovarian Function in Perimenopausal Women With Endometriosis: A Prospective Study

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