Role of Tissue Engineering in COVID-19 and Future Viral Outbreaks

Tatara, Alexander M.

doi:10.1089/ten.tea.2020.0094

Cited by 43 publications

(61 citation statements)

References 84 publications

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“…Coronavirus, which causes COVID-19, is the current major threat due to its ability to spread quickly (35,42). Until May 31, 2020 5,956,883 confirmed cases (being that the largest number of cases are concentrated in the Americas) and 366,409 deaths worldwide, which shows the seriousness of this pandemic started in December 2019.…”

Section: Infectious Diseasesmentioning

confidence: 99%

“…Until May 31, 2020 5,956,883 confirmed cases (being that the largest number of cases are concentrated in the Americas) and 366,409 deaths worldwide, which shows the seriousness of this pandemic started in December 2019. Generally, this virus causes infection in the upper respiratory tract, or, in some patients in the lower respiratory tract, presenting fever, cough and headache as main symptoms (6,34,35,42,43).…”

Section: Infectious Diseasesmentioning

confidence: 99%

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Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

et al. 2020

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Infectious diseases are a major global concern being responsible for high morbidity and mortality mainly due to the development and enhancement of multidrug-resistant microorganisms exposing the fragility of medicines and vaccines commonly used to these treatments. Taking into account the scarcity of effective formulation to treat infectious diseases, nanotechnology offers a vast possibility of groundbreaking platforms to design new treatment through smart nanostructures for drug delivery purposes. Among the available nanosystems, mesoporous silica nanoparticles (MSNs) stand out due their multifunctionality, biocompatibility and tunable properties make them emerging and actual nanocarriers for specific and controlled drug release. Considering the high demand for diseases prevention and treatment, this review exploits the MSNs fabrication and their behavior in biological media besides highlighting the most of strategies to explore the wide MSNs functionality as engineered, smart and effective controlled drug release nanovehicles for infectious diseases treatment.

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Section: Infectious Diseasesmentioning

confidence: 99%

Section: Infectious Diseasesmentioning

confidence: 99%

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

et al. 2020

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“…The World Health Organization (WHO) declared a pandemic March 11, 2020 due to novel coronavirus disease 2019 (COVID-19) [ 1 ]. COVID-19 is an infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [ [1] , [2] , [3] ]. As of September 15th , 2020, there are over 29 million confirmed cases of COVID-19 in 188 countries [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…These more severe symptoms, and the inability to effectively treat them, have led to over 930 thousand deaths globally [ 4 ]. Although therapeutic screening and vaccine development has been accelerated, no specific antiviral therapeutics are currently validated for treatment of COVID-19, and no vaccine is currently available [ 2 , 3 , 8 , 9 ]. Remarkable progress has been made on identifying and sequencing the virus, and development of diagnostic tests; however, significant research and innovation is still required to combat the global crisis [ 2 , 3 , 8 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although therapeutic screening and vaccine development has been accelerated, no specific antiviral therapeutics are currently validated for treatment of COVID-19, and no vaccine is currently available [ 2 , 3 , 8 , 9 ]. Remarkable progress has been made on identifying and sequencing the virus, and development of diagnostic tests; however, significant research and innovation is still required to combat the global crisis [ 2 , 3 , 8 , 10 , 11 ]. Specifically, better understanding of host-virus interactions at the molecular level, methods for screening therapeutics, and safe clinical translation methods are urgently needed to increase the efficiency of the global pandemic response [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Bioprinting for combating infectious diseases

Zimmerling

Chen

2020

Bioprinting

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Infectious diseases have the ability to impact health on a global scale, as is being demonstrated by the current coronavirus disease 2019 (COVID-19) pandemic. The strenuous circumstances related to this global health crises have been highlighting the challenges faced by the biomedical field in combating infectious diseases. Notably, printing technologies have advanced rapidly over the last decades, allowing for incorporating living cells in the printing process (or bioprinting) to create constructs that are able to serve as in vitro tissue or virus-disease models in combating infectious diseases. This paper describes applications of bioprinting in addressing the challenges faced in combating infectious diseases, with a specific focus on in vitro modelling and on development of therapeutic agents and vaccines. Integration of these technologies may allow for a more efficient and effective response to current and future pandemics.

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Tissue Regeneration through Cyber‐Physical Systems and Microbots

Kumar

Mirza

Choudhury³

et al. 2021

Adv Funct Materials

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Tissue engineering is a systematic approach of assembling cells onto a 3D scaffold to form a functional tissue in the presence of critical growth factors. The scaffolding system guides stem cells through topological, physiochemical, and mechanical cues to differentiate and integrate to form a functional tissue. However, cellular communication during tissue formation taking place in a reactor needs to be understood properly to enable appropriate positioning of the cells in a 3D environment. Hence, sensors and actuators integrated with cyber‐physical system (CPS) may be able to sense the tissue microenvironment and direct cells/cellular aggregates to an appropriate position, respectively. This can facilitate better cell‐to‐cell communication and cell–extracellular matrix communication for proper tissue morphogenesis. Advancements are made in the field of smart scaffolds that can morph cells/cellular aggregates after sensing the cellular microenvironment in a desired 3D architecture by providing appropriate cues. Recent scientific developments in the additive manufacturing technology have enabled the fabrication of smart scaffolds to create structural and functional tissue constructs. Sensors/actuators, cyber‐systems, smart materials, and additive manufacturing put together is expected to lead to improved tissue‐engineered medical products. The present review aims to highlight the possibilities of advancement of BioCPS for tissue engineering and regenerative medicine.

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Role of Tissue Engineering in COVID-19 and Future Viral Outbreaks

Cited by 43 publications

References 84 publications

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

Bioprinting for combating infectious diseases

Tissue Regeneration through Cyber‐Physical Systems and Microbots

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