Role of Tobacco in the Development of Oral Leukoplakia and Oral Cancer

Sabashvili, Maka; Gigineishvili, Elene; Jikia, Maia; Chitaladze, Tamta

doi:10.4172/2161-1122.1000495

Cited by 5 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we should not misunderstand the preventative effects of smoking on the malignant transformation of OL. The prevalence of OL is much higher in smoking patients than in non-smoking patients (17.9% vs. 3.9%, respectively) [ 47 – 50 ]. Taken together, our data and these studies suggest that non-smoking patients are less likely to develop OL than smoking patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of smoking status and programmed death-ligand 1 expression on the microenvironment and malignant transformation of oral leukoplakia: A retrospective cohort study

et al. 2021

View full text Add to dashboard Cite

Tobacco smoking is associated with an increased risk of oral leukoplakia and head and neck cancer. Although it has recently been reported that the establishment of an immunosuppressive microenvironment in oral potentially malignant disorders may lead to malignant transformation, it is unclear whether the microenvironments of oral potentially malignant disorders differ according to smoking status. We examined differences in programmed death-ligand 1 (PD-L1) expression and subepithelial CD163+ TAM and CD8+ cell/lymphocyte counts in the microenvironment of oral leukoplakia of smoking and non-smoking patients and investigated their associations with malignant transformation. Pathology reports and original biopsy request forms from 1995–2015 were retrospectively reviewed. Lesions clinically characterized as white plaques/lesions of the oral mucosa and pathologically diagnosed as oral epithelial dysplasia were included. Immunohistochemistry was performed to evaluate PD-L1 expression and subepithelial CD163+/CD8+ cell counts. The significance of prognostic factors in predicting malignant transformation was determined using Cox regression analysis. Statistical significance was defined as P<0.05. In total, 200 patients with oral leukoplakia were selected. The mean age at diagnosis was higher in non-smoking patients (n = 141; 66.9 years) than in smoking patients (n = 59; 60.5 years). The 5-year cumulative malignant transformation rate was higher in non-smoking patients than in smoking patients (9.3% vs. 3.0%, respectively). Oral leukoplakia was associated with significantly higher PD-L1 expression and increased numbers of subepithelial CD163+ cells in the non-smoking group compared with the smoking group. Non-smoking-related oral leukoplakia with positive PD-L1 expression was associated with a 6.97-fold (95% confidence interval: 2.14–22.7) increased risk of malignant transformation. The microenvironment of oral leukoplakia differed according to smoking status. A combination of smoking status and PD-L1 expression may predict malignant transformation in oral leukoplakia patients. This study highlights the importance of understanding the interaction between smoking and the microenvironment in oral leukoplakia.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of smoking status and programmed death-ligand 1 expression on the microenvironment and malignant transformation of oral leukoplakia: A retrospective cohort study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The definitive cause of leukoplakia is unclear. However, the most common risk factors involve the use of tobacco either in smoke (mainly) or smokeless form together with chronic alcohol consumption ( Bánóczy et al, 2001 ; Sabashvili et al, 2018 ). It is necessary to distinguish causative factors to rule out other white oral lesions such as stomatitis nicotina, the most common lesions in smokers ( Schwartz, 1965 ).…”

Section: Oral Potentially Malignant Disordersmentioning

confidence: 99%

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

2022

View full text Add to dashboard Cite

show abstract

“…Oral squamous -cell carcinoma (OSCC), is the sixth most prevalent cancer in the world.. 1 In 2018, the United States estimated 51.540 new cases of oral and pharynx (throat) cancer. The incidence for men is more than double for females with an age of 5 years survival 2 .. OSCC estimated of 90.1% of all oral cancers in Egypt 3 , the delayed diagnosis of potentially malignant symptoms is considered responsible for the late diagnosis of possibly malignant disorders due to an lack of adequate awareness of indications, disorders or risk factors, are considered to be responsible for late diagnosis of potentially malignant disorders. Surgical solution of oral cancer is considered among the most life threatening or distorting treatment of oral cancer.…”

Section: Introductionmentioning

confidence: 99%

A trial of thymoquinon loaded on gold nanoparticle as a therapy for induced squamous cell carcinoma in buccal pouch of hamster

Shata

Taha

2019

Egyptian Dental Journal

View full text Add to dashboard Cite

Objectives: Combining the anti-tumor effect of thymoquinone (TQ) with the efficient penetration of gold nanoparticles (GNPs) into cells and nuclei as an attempt to treat the induced oral squamous cell carcinoma in buccal pouch of hamster. Materials and methods: This study was carried out on forty two male Syrian golden hamsters (n=42), its age ranged from 6 to 7 weeks, weighting 90-110 gm. Animals were housed with controlled temperature and were given pellets formed of seeds, grain, cracked corn and tap water ad libitum. The hamsters were divided into: Group A: (Control groups) n=24, Group A1: eighteen animals (n=18) were served as "negative control". Subgroup A1a: Six animals were sacrificed at day zero. Subgroup A1b: Six animals were sacrificed at 14th week. Subgroup A1c: Six animals were sacrificed at 20th week. Group A2: Six animals (n=6) were considered as "positive control". DMBA was painted to the left cheek pouches, three times /week for 14weeks. Group B: Eighteen animals (n=18) were painted with DMBA to left cheek pouches three times/week for 14weeks, and subdivided into: Subgroup B1: Six animals were injected intra-peritoneal with GNPs/3 times/week for six weeks. Subgroup B2: Six animals were injected intra-peritoneal with TQ/3 times/week for six weeks.Sub-group B3: Six animals were injected intra-peritoneal with GNPs-TQ/3 times/ week for six weeks. All pouches were extracted and prepared to examined through histological examination for any structural changes and immunohistological detection of COX2. Results: Improve superior anti-inflammatory role of TQ when loaded with GNPS in COX-2 retardation and tumor size regression. Conclusion: Thymoquinon loaded on nanogold particle showed protective role in the oral cancer.

show abstract

Role of Tobacco in the Development of Oral Leukoplakia and Oral Cancer

Cited by 5 publications

References 27 publications

Effect of smoking status and programmed death-ligand 1 expression on the microenvironment and malignant transformation of oral leukoplakia: A retrospective cohort study

Effect of smoking status and programmed death-ligand 1 expression on the microenvironment and malignant transformation of oral leukoplakia: A retrospective cohort study

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

A trial of thymoquinon loaded on gold nanoparticle as a therapy for induced squamous cell carcinoma in buccal pouch of hamster

Contact Info

Product

Resources

About