Role of tonsillectomy and adenoidectomy in parental satisfaction of treatments for PANDAS

Prasad, Navin; Johng, Stephanie Y.; Powell, Daniel; Williams, Matthew; Latimer, Elizabeth; Harley, Earl H.

doi:10.1016/j.amjoto.2021.102963

Cited by 2 publications

(6 citation statements)

References 27 publications

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“…We provided 11 articles in our systematic literature review for a total of 473 patients surgically or medically treated. The patients’ average age was 9.18 ± 1.47 years [ 14 , 15 , 20 , 21 , 22 , 23 , 24 , 32 ]. In addition, a significant difference in sex ratio was reported (59.9% male vs. 40.1% female).…”

Section: Resultsmentioning

confidence: 99%

“…Among the various diagnostic hypotheses reported in the literature, streptococcal and other infections have been shown to trigger the development of symptoms such as OCD, tics and behavioral disturbances [ 2 , 3 , 5 ]. Therefore, numerous studies have been performed on neurological outcomes in PANDAS patients undergoing medical or surgical treatments, with the principle of adenotonsillar infection as the primary target [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 32 , 33 ]. Pavone et al examined whether adenotonsillectomy could impact both disease remission and affect the clinical course, streptococcal antibody titers, neuronal antibodies, or the clinical severity of the obsessive-compulsive disorder (OCD) [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Four papers included 129 patients surgically treated, reporting both pre-and posttreatment OCD ratio (event/total) according to fixed effect model (Table 1) [13,22,23,32]. All patients underwent adenotonsillectomy for PANDAS, and the results obtained were compared with a control group.…”

Section: Surgical Treatmentmentioning

confidence: 99%

“…Four papers included 129 patients surgically treated, reporting both pre-and post-treatment OCD ratio (event/total) according to fixed effect model ( Table 1 ) [ 13 , 22 , 23 , 32 ].…”

Section: Surgical Treatmentmentioning

confidence: 99%

“…Antibiotics (penicillin V, azithromycin), anti-inflammatory drugs (cyclooxygenase (COX) inhibitors, corticosteroids), immunomodulating treatments (intravenous immunoglobulin –IVIG. plasma exchange) are the most applied treatment singularly or in association [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Obsessive-Compulsive Disorder in PANS/PANDAS in Children: In Search of a Qualified Treatment—A Systematic Review and Metanalysis

et al. 2022

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Background: Several treatment options have been proposed for pediatric acute-onset neuropsychiatric syndrome/pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANS/PANDAS). Still, no clear therapeutic protocol has been recognized to prevent these neuropsychiatric diseases. The study aims to report on the literature evidence and different treatment strategies related to these disorders. Methods: We analyzed the last 20 years’ English language literature and performed a comprehensive review of the PANS/PANDAS treatment, including studies reporting OCD outcomes post-treatment follow-up. Results: We covered 11 articles in our systematic literature review for a total of 473 patients, of which four studies included 129 surgical subjects and seven papers with 326 medically treated patients. Pooled outcomes analysis, surgical and medical treatment reported an OCD reduction, but no statistical significance was obtained (p < 0.05 for both). Conclusions: Surgical therapy in selected patients can lead to promising results, although further evidence is needed. On the other hand, the role of medical therapy remains controversial, often due to the lack of univocal curative protocols and variable responses depending on the drug used and the timing of administration. Therefore, further investigations are necessary to clarify the most appropriate therapeutic procedure.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Surgical Treatmentmentioning

confidence: 99%

“…Four papers included 129 patients surgically treated, reporting both pre-and post-treatment OCD ratio (event/total) according to fixed effect model ( Table 1 ) [ 13 , 22 , 23 , 32 ].…”

Section: Surgical Treatmentmentioning

confidence: 99%