Role of topical hemocoagulase in postoperative wound healing following dentoalveolar extraction

Abstract

Background: Wound healing consists of sequential overlapping events, namely, hemostasis, inflammation, proliferation and remodelling. Disruption of one or more of these events results in impaired healing of the wound which causes functional, esthetic and emotional burdens in the future. Hemocoagulase is an enzyme derived from snake venom which is widely used for its hemostatic properties. In recent times, it has shown to enhance wound healing and reduce scar formations. The objective of this systematic review is to compare the effectiveness of topical hemocoagulase and placebo/control in postoperative wound healing following dentoalveolar extraction. Methodology: A systematic review was carried out to explore the use of hemocoagulase in wound healing of dental extraction sockets. The Databases of PubMed, Cochrane and Google scholar were searched for the related topics along with a complimentary manual search of all oral surgery journals till December 2020. Results: A total of eleven studies were revealed on data search. After application of inclusion and exclusion criteria based on the filtering process, two clinical trials were included for final appraisal. Of the two clinical trials, one compared topical hemocoagulase with placebo and one clinical trial compared topical hemocoagulase with control. Both trials included patients undergoing bilateral dental extraction.