Role of Topical Insulin Eye Drop and Its Comparison With Pack-CXL in Case of Non Healing Corneal Ulcer

Abstract

Present study evaluates efcacy of topical insulin eye drops and PACK-CXL in treatment of non-healing corneal ulcer. For this total 20 patients of corneal ulcer were taken and categorise as two groups, Group-1 and Group-2. Patients of Group-1 were treated with topical insulin eye drop, while 2 Group-2 with PACK-CXL. In result, mean area of ulcer before starting treatment in Group-1 was 25.45 ± 16.5 mm and we observed complete corneal reepithelization in all patients, with mean duration of reepithelization seen in 35 days. In group-2 mean area of non-healing ulcer before 2 starting treatment was 20.58±10.63 mm , after PACK-CXL, we observed complete corneal reepithelization in all patients with, mean duration of 25.4 days. Final visual acuity was improved from baseline in both groups. Both topical Insulin eye drop and PACK-CXL can promote and accelerate corneal reepithelization of non-healing corneal ulcers but topical insulin eye drop is cost-effective with no adverse effect