Role of Topical Phenytoin in Diabetic Foot Ulcer Care – A Randomised Control Trial

Soundarapandiyan, R; Srikanth, R.; Udhayasankar,

doi:10.14260/jemds/2017/60

jemds

2017

DOI: 10.14260/jemds/2017/60

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Role of Topical Phenytoin in Diabetic Foot Ulcer Care – A Randomised Control Trial

R Soundarapandiyan¹,

R. Srikanth²,

Udhayasankar Udhayasankar³

Abstract: BACKGROUNDIndia is becoming the world capital of diabetes mellitus. Diabetes mellitus has many number of complications. Patients with diabetes mellitus seek medical attention for their foot problems more often. Among those who developed diabetic foot problems, 15% underwent some type of toe to foot amputations.Aim of this study is to assess the efficiency of topical phenytoin on diabetic foot ulcers, Meggitt's grade 1 and 2.

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2024

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Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies

Wang,

Zhang,

Zhang

et al. 2024

Medicinal Research Reviews

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Diabetic foot ulcer (DFU) is one of the most costly and serious complications of diabetes. Treatment of DFU is usually challenging and new approaches are required to improve the therapeutic efficiencies. This review aims to update new and upcoming adjunctive therapies with noninvasive characterization for DFU, focusing on bioactive dressings, bioengineered tissues, mesenchymal stem cell (MSC) based therapy, platelet and cytokine‐based therapy, topical oxygen therapy, and some repurposed drugs such as hypoglycemic agents, blood pressure medications, phenytoin, vitamins, and magnesium. Although the mentioned therapies may contribute to the improvement of DFU to a certain extent, most of the evidence come from clinical trials with small sample size and inconsistent selections of DFU patients. Further studies with high design quality and adequate sample sizes are necessitated. In addition, no single approach would completely correct the complex pathogenesis of DFU. Reasonable selection and combination of these techniques should be considered.

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Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies

Wang,

Zhang,

Zhang

et al. 2024

Medicinal Research Reviews

View full text Add to dashboard Cite

show abstract

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Role of Topical Phenytoin in Diabetic Foot Ulcer Care – A Randomised Control Trial

Cited by 1 publication

References 13 publications

Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies

Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies

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