Role of touch imprint and core biopsy for detection of tumor metastases in bone marrow

Kjurkchiev, Galen; Valkov, Ivan

doi:10.1002/(sici)1097-0339(199805)18:5<323::aid-dc2>3.0.co;2-b

Cited by 9 publications

(4 citation statements)

References 5 publications

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“…Some nucleated erythrocytes with megaloblastic changes were easily mistaken for myeloblasts without immunophenotype on trephine sections, so the diagnostic accuracy of imprints for MA was higher than sections. Consistent with the results described by Kjurkchiev et al, 22 we demonstrated that the diagnostic accuracy of BM sections for metastatic carcinoma was higher than smears. As detection of metastatic tumour with imprints has not yet been adequately explored, here we revealed that their diagnostic accuracy for metastatic carcinoma was higher than smears, but lower than trephine sections.…”

Section: Discussionsupporting

confidence: 93%

Role of bone marrow imprints in haematological diagnosis: a detailed study of 3781 cases

Gong

et al. 2010

Cytopathology

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Section: Discussionsupporting

confidence: 93%

Role of bone marrow imprints in haematological diagnosis: a detailed study of 3781 cases

Gong

et al. 2010

Cytopathology

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“…The imprint slides can be stained by the Wright-Giemsa technique for morphologic evaluation or used for cytochemical analysis or immunoperoxidase staining. Several studies have demonstrated the value of biopsy imprint preparations in the detection of malignancy (81)(82)(83)(84)(85)(86).…”

Section: Preparing Bone Marrow Aspirate Smearsmentioning

confidence: 99%

A pathologist's perspective on bone marrow aspiration and biopsy: I. performing a bone marrow examination

Riley

Hogan

Pavot

et al. 2004

Clinical Laboratory Analysis

101

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The bone marrow aspirate and biopsy is an important medical procedure for the diagnosis of hematologic malignancies and other diseases, and for the follow-up evaluation of patients undergoing chemotherapy, bone marrow transplantation, and other forms of medical therapy. During the procedure, liquid bone marrow is aspirated from the posterior iliac crest or sternum with a special needle, smeared on glass microscope slides by one of several techniques, and stained by the Wright-Giemsa or other techniques for micro-scopic examination. The bone marrow core biopsy is obtained from the posterior iliac crest with a Jamshidi or similar needle and processed in the same manner as other surgical specimens. Flow cytometric examination, cytochemical stains, cytogenetic and molecular analysis, and other diagnostic procedures can be performed on bone marrow aspirate material, while sections prepared from the bone marrow biopsy can be stained by the immunoperoxidase or other techniques. The bone marrow procedure can be performed with a minimum of discomfort to the patient if adequate local anesthesia is utilized. Pain, bleeding, and infection are rare complications of the bone marrow procedure performed at the posterior iliac crest, while death from cardiac tamponade has rarely occurred from the sternal bone marrow aspiration. The recent development of bone marrow biopsy needles with specially sharpened cutting edges and core-securing devices has reduced the discomfort of the procedure and improved the quality of the specimens obtained.

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“…The imprint microscopic slides are stained with the Wright-Giemsa method for morphologic examination or employed for cytochemical investigation or immune-peroxidase staining. Several previous studies have shown the importance of biopsy imprints in the examination of malignancy [28][29][30]. Microscopic investigation of the smear associated with bone marrow is very helpful in the diagnosis of multi-plehaematologic disorders like iron (Fe) deficiency anemia, acute leukemia, and secondary deposits inside the bone marrow.…”

Section: Preparation Bone Marrow Aspiration Smearsmentioning

confidence: 99%

Bone Marrow Aspiration and Biopsy in Critical Pediatric Patients: A Pathologist’s Perspective

Bhaskar¹

2021

Cureus

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Bone marrow aspiration (BMA) and bone marrow biopsy (BMB), are medical modalities for the detection of non-malignant diseases as well as hematological malignancies in children. BMA attained momentum in the past few years owing to the possibility of achieving hematopoietic stem cells. Liquid bone marrow is aspirated through posterior/anterior iliac crest, tibia, and vertebral spinous process during BMA procedure in children for assessment of morphology at the microscopic level while BMB allows for cytological evaluation of marrow. It is also used for molecular genetics, immune-phenotypic, cytogenetics, and other specialized examinations. Additionally, BMA is also helpful in the reconstruction of tissue. These procedures should be performed by a specialist who has knowledge about the indication, contradictions, and hazards of these procedures due to their invasive nature. Still, there are no transparent guidelines available especially in the case of BMA for children. The purpose of this overview article is to focus on the specific guidelines to carry out the BMA and BMB in children and the techniques as well as complications associated with the BMA and BMB.

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Role of touch imprint and core biopsy for detection of tumor metastases in bone marrow

Cited by 9 publications

References 5 publications

Role of bone marrow imprints in haematological diagnosis: a detailed study of 3781 cases

Role of bone marrow imprints in haematological diagnosis: a detailed study of 3781 cases

A pathologist's perspective on bone marrow aspiration and biopsy: I. performing a bone marrow examination

Bone Marrow Aspiration and Biopsy in Critical Pediatric Patients: A Pathologist’s Perspective

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