Role of Traditional Chinese Herbal Medicines in Functional Gastrointestinal and Motility Disorders

Sankararaman, Senthilkumar; Velayuthan, Sujithra; Chen, Youqin; Robertson, Jason O.; Sferra, Thomas J.

doi:10.1007/s11894-022-00843-8

Cited by 14 publications

(9 citation statements)

References 86 publications

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“…Despite the importance of gastrointestinal motility, it is difficult to choose suitable treatment because the pathophysiological stage varies due to delayed gastric emptying, hypersensitivity to gastric expansion, adverse reactions to duodenal fat or acid, and psychoneurotic disorders [ 30 ]. According to this trend, various traditional medical treatment methods and approaches to treatment of gastrointestinal motility abnormalities are being made [ 31 ]. Research on gastrointestinal motility abnormalities in traditional medicine has been actively conducted [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to this trend, various traditional medical treatment methods and approaches to treatment of gastrointestinal motility abnormalities are being made [ 31 ]. Research on gastrointestinal motility abnormalities in traditional medicine has been actively conducted [ 31 ]. It was found that the possibility of controlling gastrointestinal movement and reduced gastrointestinal movement increased due to various traditional medicines, such as Pyungwi-san [ 32 ], Lizhong Tang [ 33 ], Poncirus trifoliate fruit [ 34 ], So-Cheong-Ryong-Tang [ 35 ], San-Huang-Xie-Xin-tang [ 36 ], Schisandra chinensis [ 37 ], Ge-Gen-Tang [ 38 ], Liriope Platyphylla Wang Et tang [ 39 ], Hwangryunhaedok-tang [ 40 ], Gamisoyo-San [ 41 ], Banhasasim-Tang [ 42 ], and Pinellia ternata Breitenbach [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

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Network Pharmacological Analysis and Experimental Validation of the Effect of Smilacis Glabrae Rhixoma on Gastrointestinal Motility Disorder

Choi

Lee

Seo

et al. 2023

Plants

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Gastrointestinal motility disorder (GMD) is a disease that causes digestive problems due to inhibition of the movement of the gastrointestinal tract and is one of the diseases that reduce the quality of life of modern people. Smilacis Glabrae Rhixoma (SGR) is a traditional herbal medicine for many diseases and is sometimes prescribed to improve digestion. As a network pharmacological approach, we searched the TCMSP database for SGR, reviewed its constituents and target genes, and analyzed its relevance to gastrointestinal motility disorder. The effects of the SGR extract on the pacemaker activity in interstitial cells of Cajal (ICC) and gastric emptying were investigated. In addition, using the GMD mouse model through acetic acid (AA), we investigated the locomotor effect of SGR on the intestinal transit rate (ITR). As a result of network pharmacology analysis, 56 compounds out of 74 candidate compounds of SGR have targets, the number of targets is 390 targets, and there are 904 combinations. Seventeen compounds of SGR were related to GMD, and as a result of comparing the related genes with the GMD-related genes, 17 genes (active only) corresponded to both. When looking at the relationship network between GMD and SGR, it was confirmed that quercetin, resveratrol, SCN5A, TNF, and FOS were most closely related to GMD. In addition, the SGR extract regulated the pacemaker activity in ICC and recovered the delayed gastric emptying. As a result of feeding the SGR extract to AA-induced GMD mice, it was confirmed that the ITR decreased by AA was restored by the SGR extract. Through network pharmacology, it was confirmed that quercetin, resveratrol, SCN5A, TNF, and FOS were related to GMD in SGR, and these were closely related to intestinal motility. Based on these results, it is suggested that SGR in GMD restores digestion through the recovery of intestinal motility.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Network Pharmacological Analysis and Experimental Validation of the Effect of Smilacis Glabrae Rhixoma on Gastrointestinal Motility Disorder

Choi

Lee

Seo

et al. 2023

Plants

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“…As an important component of traditional Chinese medicine, many Chinese herbal formulas with anti-inflammatory, antibacterial, immunomodulatory, and digestion-promoting functions have been developed [13][14][15][16][17][18]. For instance, traditional Chinese medicine theory suggests that Radix Astragali has anti-inflammatory effects [16], and four phenolic derivatives isolated from Radix Astragali exhibit potent inhibitory effects on tumor necrosis factor-α (TNF-α) production and TNF-α, cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), IL-6, and inducible nitric oxide synthase (iNOS) mRNA expression at 50 µM in lipopolysaccharide (LPS)-induced mouse peritoneal macrophages [19].…”

Section: Introductionmentioning

confidence: 99%

Fermented Chinese Herbs Improve the Growth and Immunity of Growing Pigs through Regulating Colon Microbiota and Metabolites

Zhang,

Shu,

et al. 2023

Animals

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(1) Background: the development of new antibiotic substitutes to promote pig growth and health has become an important way to solve the current dilemma and promote the pig industry. (2) Methods: to assess the effects of a fermented Chinese herbal (FCH) formula on the growth and immunity of growing pigs, 100 Duroc × Landrace × Yorshire three-way crossed growing pigs were randomly divided into control and treatment groups that were fed a basal diet, and a basal diet with 1% (group A), 2% (group B), and 3% (group C) FCH formulas, respectively. A sixty-day formal experiment was conducted, and their growth and serum indices, colonic microbiota, and metabolites were analyzed. (3) Results: the daily gain of growing pigs in groups A, B, and C increased by 7.93%, 17.68%, and 19.61%, respectively, and the feed-to-gain ratios decreased by 8.33%, 15.00%, and 14.58%, respectively. Serum immunity and antioxidant activities were significantly increased in all treatment groups. Particularly, adding a 2% FCH formula significantly changed the colon’s microbial structure; the Proteobacteria significantly increased and Firmicutes significantly decreased, and the metabolite composition in the colon’s contents significantly changed. (4) Conclusions: these results indicate that the FCH formula is a good feed additive for growing pigs, and the recommended addition ratio was 3%.

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“…Traditional medicine, dietary supplements, and natural herbal products containing herbal blends have flooded the markets in many Western countries (1). The public relies on drug labels for drug information (2).…”

Section: Introductionmentioning

confidence: 99%

Next-generation sequencing and targeted quantitative real-time polymerase chain reaction for detection of Akebiae Caulis in the traditional Chinese medical formula Longdan Xiegan Wan

Song¹,

Yang²,

Wang³

et al. 2022

Ann Transl Med

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Background: Akebiae Caulis (Mu Tong) is commonly misused by Aristolochiae Manshuriensis Caulis (Guan Mutong) and Clematidis Armandii Caulis (Chuan Mutong), which are nephrotoxic and carcinogenic. However, in the Pharmacopoeia of the People's Republic of China (2015 Edition), the method for determining Akebiae Caulis remains undefined. Methods: We used DNA barcode-based next-generation sequencing (NGS) combined with quantitative real-time polymerase chain reaction (qPCR) to detect Akebiae Caulis in Longdan Xiegan Wan (LDXGW) for the first time. Compared with chromatographic studies, NGS enables better evaluation of the ingredient components of traditional Chinese medicine (TCM) preparations. The feasibility of qPCR using speciesspecific primers to determine the authenticity of species has been validated. In this study, the constituents of Akebiae Caulis in LDXGW from three different manufacturers were scanned by NGS. The independently developed qPCR detection primers of Akebiae Caulis, Aristolochiae Manshuriensis Caulis, and Clematidis Armandii Caulis were specifically used to analyze the LDXGW mentioned above. Results:The results showed that qPCR detected Clematidis Armandii Caulis in all commercial samples. Meanwhile, NGS detected the counterfeit species Clematis peterae (Tie-Xian Lian) in all samples. We found that qPCR shows a difference in detecting Akebiae Caulis, but it was not able to identify the unknown additives and adulterants for the primer pairs of Clematidis Armandii Caulis.Conclusions: Hence, it is sensitive and rapid, qPCR is not suitable for detection alone. The NGS approaches offer important novel insights that complement the qPCR method. The combination of NGS and qPCR will be a powerful complement to traditional identification methods of TCM substances.

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Role of Traditional Chinese Herbal Medicines in Functional Gastrointestinal and Motility Disorders

Cited by 14 publications

References 86 publications

Network Pharmacological Analysis and Experimental Validation of the Effect of Smilacis Glabrae Rhixoma on Gastrointestinal Motility Disorder

Network Pharmacological Analysis and Experimental Validation of the Effect of Smilacis Glabrae Rhixoma on Gastrointestinal Motility Disorder

Fermented Chinese Herbs Improve the Growth and Immunity of Growing Pigs through Regulating Colon Microbiota and Metabolites

Next-generation sequencing and targeted quantitative real-time polymerase chain reaction for detection of Akebiae Caulis in the traditional Chinese medical formula Longdan Xiegan Wan

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