2022
DOI: 10.3390/ijms23147802
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Role of Transposable Elements in Genome Stability: Implications for Health and Disease

Abstract: Most living organisms have in their genome a sizable proportion of DNA sequences capable of mobilization; these sequences are commonly referred to as transposons, transposable elements (TEs), or jumping genes. Although long thought to have no biological significance, advances in DNA sequencing and analytical technologies have enabled precise characterization of TEs and confirmed their ubiquitous presence across all forms of life. These findings have ignited intense debates over their biological significance. T… Show more

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Cited by 34 publications
(22 citation statements)
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“…Alterations in heterochromatic histone modifications can also directly affect DNA damage repair efficiency since many histone modifications have been implicated in promoting or inhibiting the recruitment of specific repair proteins [ 80 ]. In addition to heterochromatin destructuration, transposition events could be a further source of DNA strand breakage, which compromises genome integrity and stability [ 81 , 82 , 83 , 84 ]. Therefore, to verify whether WiFi radiation can impact genomic stability, we analyzed metaphase chromosomes obtained from brains of third instar larvae chronically exposed to WiFi radiation (from embryo to L3).…”
Section: Resultsmentioning
confidence: 99%
“…Alterations in heterochromatic histone modifications can also directly affect DNA damage repair efficiency since many histone modifications have been implicated in promoting or inhibiting the recruitment of specific repair proteins [ 80 ]. In addition to heterochromatin destructuration, transposition events could be a further source of DNA strand breakage, which compromises genome integrity and stability [ 81 , 82 , 83 , 84 ]. Therefore, to verify whether WiFi radiation can impact genomic stability, we analyzed metaphase chromosomes obtained from brains of third instar larvae chronically exposed to WiFi radiation (from embryo to L3).…”
Section: Resultsmentioning
confidence: 99%
“…Repetitive elements have been minimally explored in felids despite their high genome occupancy and role in phenotype evolution ( 105–108 ). SINE element insertions are major sources of genomic diversity in canids, with links to multiple phenotypes in domestic dogs ( Canis lupus familiaris ) including early retinal degeneration, polyneuropathy, myopathy, and merle coat color ( 109–115 ).…”
Section: Discussionmentioning
confidence: 99%
“…Repetitive elements have been minimally explored in felids despite their high genome occupancy and role in phenotype evolution [105][106][107][108] . SINE element insertions are major sources of genomic diversity in canids, with links to multiple phenotypes in domestic dogs (Canis lupus familiaris) including early retinal degeneration, polyneuropathy, myopathy, and merle coat color [109][110][111][112][113][114][115] .…”
Section: Discussionmentioning
confidence: 99%