Role of tuberculin skin test in latent tuberculosis infection in HIV patients in a tertiary care hospital of India

Patil, Shital; Phutane, Mukund; Mundkar, Sanjay

doi:10.4103/2224-4018.141841

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Several studies indicated the history of contact with tuberculosis patients as predictive factors for TST-positive results. Some of them reported a positive TST of 12-15% and even more along with the incidence of latent infection among hospital personnel 10,11 . Therefore, considering the varied results of previous studies and since more attention has been paid to the prevalence of this infection in different studies, particularly in Iran, the present study was conducted to determine the incidence of latent tuberculosis infection and its predictive factors among the personnel of Ayatollah Rouhani Hospital in Babol.…”

Section: Introductionmentioning

confidence: 99%

Incidence and Predictive Factors of Latent Tuberclosis Infection amongst Personnel of Ayatollah Rouhani Hospital in Babol, 2015-2016

2018

J Liaquat Uni Med Health Sci

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OBJECTIVE: The current study was designed to determine the incidence of latent TB and its predictive factors. METHODOLOGY: This was cross-sectional prospective study. Two tuberculin skin tests (TST) were performed in 400 health care staff (HCWs) of Ayatollah Rouhani Hospital Babol over one year and during the interview Age, Sex, Occupation, History of contact with tuberculosis and BCG scars were performed. Positive skin test was considered 10 mm; People with skin test less than 10 mm after one year were re-tested. An increase of more than 10 mm in the second test in negative PPD subjects was considered as a positive test. RESULTS: The prevalence of latent TB was 14.7% among the 400 health workers. 71.7% were women. The average age was 32.7 years. The incidence of latent tuberculosis was 6% (18 cases): technicians had the highest incidence (8.8%) and the nursing staff (6.6%), while services (2.5%) and administrative staff had the lowest incidence (0%). Out of these 18 people, 17 (94.4%) had reported a history of a patient with tuberculosis (TB) patient. CONCLUSION: According to the results of the study, the incidence of latent tuberculosis in this center is intermediate. The most important risk factor was the work experience of more than five years. Healthcare personnel training and infection control programs must be addressed adequately.

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Section: Introductionmentioning

confidence: 99%

Incidence and Predictive Factors of Latent Tuberclosis Infection amongst Personnel of Ayatollah Rouhani Hospital in Babol, 2015-2016

2018

J Liaquat Uni Med Health Sci

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Prevalence of Tuberculosis Infection among Various Risk Groups in India: A Systematic Review and Meta-Analysis

Chauhan,

Parmar,

Dash

et al. 2024

Indian Journal of Community Medicine

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Treatment of tuberculosis (TB) infection (TBI) to prevent active TB disease is a key component of the National Strategic Plan to end TB in India, without which the strategies to end TB would be futile. There is a need to rapidly scale up access to effective shorter regimens for tuberculosis preventive treatment (TPT) to a wider set of risk groups. This applies for identifying high-risk groups for TPT expansion. Thus, our aim with this review is to determine the TBI prevalence in different risk groups in India. We searched databases like Embase, Medline, Scopus, and CINAHL for studies published between 2012 and 2023 to estimate TBI in different risk groups in India. The PRISMA guidelines were followed when reviewing the publications, and a predetermined search strategy was used to find relevant sources across various databases. Using MetaXL (MS excel) software, we pooled data based on a random-effects model, along with heterogeneity testing using Cochrane’s Q and I2 statistic. A total of 68 studies were included from 10,521 records. TBI pooled prevalence was estimated using the IGRA data, while in the absence of IGRA data, TST data were utilized. The key findings revealed a total of 36% pooled TBI prevalence for all risk factors, 59% among smokers, 53% among diabetics and alcoholics, 48% among malnourished, 47% among contacts of TB patients, 44% among HIV, 36% among pregnant women, 35% among COVID-19 patients, 31% among healthcare workers, 18% among sarcoidosis patients, and 15% among rheumatoid arthritis patients in India. Our review depicted a high TBI burden among groups such as diabetes mellitus, smokers, malnourished, and alcoholics. WHO has yet to recommend for systematic screening and treatment for TBI among these groups for want of evidence which this study provides, highlighting the need to reprioritize the risk groups for tailored TPT strategies.

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The prevalence of tuberculosis infection in India: A systematic review and meta-analysis

Chauhan

Parmar²,

Dash

et al. 2023

Indian Journal of Medical Research

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Background & objectives: The National Prevalence Survey of India (2019-2021) estimated 31 per cent tuberculosis infection (TBI) burden among individuals above 15 years of age. However, so far little is known about the TBI burden among the different risk groups in India. Thus, this systematic review and meta-analysis, aimed to estimate the prevalence of TBI in India based on geographies, sociodemographic profile, and risk groups. Methods: To identify the prevalence of TBI in India, data sources such as MEDLINE, EMBASE, CINAHL, and Scopus were searched for articles reporting data between 2013-2022, irrespective of the language and study setting. TBI data were extracted from 77 publications and pooled prevalence was estimated from the 15 community-based cohort studies. Articles were reviewed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines and were sourced using a predefined search strategy from different databases. Results: Out of 10,521 records, 77 studies (46 cross-sectional and 31 cohort studies) were included. The pooled TBI prevalence for India based on the community-based cohort studies was estimated as 41 per cent [95% confidence interval (CI) 29.5-52.6%] irrespective of the risk of acquiring it, while the estimation was 36 per cent (95% CI 28-45%) prevalence observed among the general population excluding high-risk groups. Regions with high active TB burden were found to have a high TBI prevalence such as Delhi and Tamil Nadu. An increasing trend of TBI was observed with increasing age in India. Interpretation & conclusions: This review demonstrated a high prevalence of TBI in India. The burden of TBI was commensurate with active TB prevalence suggesting possible conversion of TBI to active TB. A high burden was recorded among people residing in the northern and southern regions of the country. Such local epidemiologic variation need to be considered to reprioritize and implement-tailored strategies for managing TBI in India.

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Role of tuberculin skin test in latent tuberculosis infection in HIV patients in a tertiary care hospital of India

Cited by 3 publications

References 13 publications

Incidence and Predictive Factors of Latent Tuberclosis Infection amongst Personnel of Ayatollah Rouhani Hospital in Babol, 2015-2016

Incidence and Predictive Factors of Latent Tuberclosis Infection amongst Personnel of Ayatollah Rouhani Hospital in Babol, 2015-2016

Prevalence of Tuberculosis Infection among Various Risk Groups in India: A Systematic Review and Meta-Analysis

The prevalence of tuberculosis infection in India: A systematic review and meta-analysis

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