Role of TWIST proteins in cancer progression

Bastid, Jérémy; Ciancia, Claire; Puisieux, Alain; Ansieau, Stéphane

doi:10.4267/2042/44856

Cited by 7 publications

(7 citation statements)

References 115 publications

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“…In chronic inflammatory diseases, proliferation and differentiation of B-cells to immunoglobulin-secreting cells is influenced by factors such as IL-17 and B-cell activating factor (BAFF). Twist-1 affects IL-17 and BAFF production and protects B-cells against apoptosis and is essential for survival and proliferation of memory B-cells and naïve B-cells [14,22]. Although weak expression of Twist proteins has been shown in normal B-lymphocytes, their role in these cells remains unknown, and further studies should be conducted to understand the role of Twist proteins in these cells [52].…”

Section: Physiological Roles Of Twist In Bm Nichementioning

confidence: 98%

“…The role of Twist proteins (especially Twist-1) in cancer initiation is mediated by inhibition of natural processes of senescence and apoptosis induced by different pathways like p53/p21 and p16 INK4a /pRB pathway (Fig. 1) [14]. DNA damage induces the activation of several protein kinases, including ATM, ATR, chk1, chk2 and DNA-dependent kinases.…”

Section: Physiological Roles Of Twist In Bm Nichementioning

confidence: 99%

“…It has recently been demonstrated that the expression of Twist1/2 is a key regulator of B-cell function in inflammatory conditions such as autoimmune diseases [14]. In chronic inflammatory diseases, proliferation and differentiation of B-cells to immunoglobulin-secreting cells is influenced by factors such as IL-17 and B-cell activating factor (BAFF).…”

Section: Physiological Roles Of Twist In Bm Nichementioning

confidence: 99%

“…In the early stages of cancer, Twist-1 causes cancer progression and resistance to therapy via neutralization of apoptotic and aging processes. Increased expression of Twist proteins has been reported to play a significant role in cancer initiation, progression and metastasis in several human solid tumors, including different types of carcinomas and sarcomas, gliomas, neuroblastomas as well as melanomas [13,14]. Moreover, changing expression of these proteins has been reported in a number of hematologic malignancies such as Fig.…”

Section: Introductionmentioning

confidence: 97%

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Twist as a new prognostic marker in hematological malignancies

et al. 2015

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Twist proteins are members of basic helix-loop-helix family and are major regulators of embryogenesis. In adult humans, Twist proteins are mainly expressed in precursor cells, including myogenic, osteoblastic, chondroblastic and myelomonocytic lineages, maintaining their undifferentiated state. In addition, they play important roles in lymphocyte function and maturation. Recently, several studies have reported regulatory roles for Twist in the function and development of hematopoietic cells as well as in survival and development of numerous hematological malignancies. It is activated by numerous signal transduction pathways, including Akt, nuclear factor κB, Wnt, signal transducer and activator of transcription 3, mitogen-activated protein kinase and Ras signaling. Activated Twist has an anti-apoptotic role and protects cancer cells from apoptotic cell death. In addition, overexpression of Twist promotes the process of epithelial-mesenchymal transition, which has an essential role in cancer metastasis. Hereby, we review the aberrant expression of Twist in hematopoietic malignancies such as leukemias, lymphomas and myelodysplastic syndrome, which is related with poor prognosis and drug resistance in these disorders. Inactivation of Twist by small RNAs technology or chemotherapeutic inhibitors targeting Twist and upstream or downstream molecules of Twist signaling pathways may be helpful in management of disease to improve treatment strategies in malignancies.

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Section: Physiological Roles Of Twist In Bm Nichementioning

confidence: 98%

Section: Physiological Roles Of Twist In Bm Nichementioning

confidence: 99%

Section: Physiological Roles Of Twist In Bm Nichementioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Twist as a new prognostic marker in hematological malignancies

et al. 2015

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“…Twist gene expression is upregulated in a number of types of cancer, including prostate, lung and breast cancer (11). The upregulation of Twist is associated with angiogenesis and metastasis (11).…”

Section: Introductionmentioning

confidence: 99%

Activation of the Wnt/β-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of Twist

Sun

Liu

2017

Oncology Letters

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Abstract. The Wnt signaling pathway regulates a number of biological processes. In the present study, the association between the Wnt signaling pathway and the pathogenesis of cervical cancer was investigated in the human cervical cancer CaSki cell line. An MTT assay was used to screen various concentrations of lithium chloride for use in subsequent experiments. Following incubation of CaSki cells with 0.05 and 0.1 mol/l lithium chloride, Twist and β-catenin were markedly upregulated at the mRNA and protein levels, respectively, compared with the untreated group, as measured by reverse transcription-polymerase chain reaction and western blotting. The results of the present study indicate that Wnt activation (which was induced by lithium chloride) and the subsequent upregulation of Twist may represent one of the molecular mechanisms underlying the occurrence and development of cervical cancer.

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