Role of type 2 innate lymphoid cell and its related cytokines in tumor immunity

Wan, Jie; Cai, Wei; Wang, Huixuan; Cheng, Jianjun; Su, Zhaoliang; Wang, Shengjun; Xu, Huaxi

doi:10.1002/jcp.29287

Cited by 8 publications

(4 citation statements)

References 97 publications

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“…Recent years, the role of ILC2s in tumor diseases was achieved more and more attention. Studies have proved that ILC2s have a dual role in tumors, so more studies need to be done to detect the real or exactly function in the development of tumor diseases [30,31]. ILC2s are characterized by secreting type 2 cytokines, and the role of ILC2s-derived IL-4, IL-5, IL-9 and IL-13 have been reported.…”

Section: Discussionmentioning

confidence: 99%

Tumor Cells Inhibit the Activation of ILC2s Through Up-Regulating PD-1 Expression

Xu¹

2022

J Oncology

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Up-regulating programmed cell death ligand-1 (PD-L1) expressed on tumor cells and tumor-infiltrating myeloid cells interacting with up-regulated programmed cell death-1 (PD-1) expressed on tumor-infiltrating lymphoid cells greatly hinder their tumor-inhibiting effect. It is necessary to explore the deep mechanism of this negative effect, so as to find the potential methods to improve the immunotherapy effect.

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Section: Discussionmentioning

confidence: 99%

Tumor Cells Inhibit the Activation of ILC2s Through Up-Regulating PD-1 Expression

Xu¹

2022

J Oncology

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“…3.2 Group 1 innate lymphocytes is decreased in colon cancer microenvironment and is positive correlation with M1 phenotype macrophage Previously studies showed that ILCs are abundant in intestinal tissue, and ILC2s-derived IL-4 can promote tumorigenesis by polarizing macrophage towards a pro-tumorigenic M2 phenotype [28][29][30]. Furthermore, group 1 innate lymphocytes are characterized by secreting IFN-γ, which can polarize macrophage towards M1 phenotype [31,32].…”

Section: Macrophage Is Up-regulated In Colon Cancer Microenvironment ...mentioning

confidence: 99%

Group 1 innate lymphocyte-derived IFN-γ regulates macrophage alternative activation in colon cancer

Zhang

et al. 2022

Preprint

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Background Tumor-associated macrophage (TAM) is an important innate immune cell-subset in tumor microenvironment, and that is also a pivotal orchestrator of tumor-promoting inflammation and tumor progression. Evidence proved that TAMs are up-regulated in a great number of cancers, and most of them are alternative activated M2 phenotype, which greatly promote the progress of cancer diseases. Group 1 innate lymphocytes including conventional NK cells and type 1 innate lymphocytes (ILC1s), are abundant in intestinal tissue, and characterized by expressing transcription factor T-bet and secreting interferon (IFN)-γ, which can promote the macrophage to classically activated anti-tumor M1 phenotype. However, the relationship between these two cell subsets remains unclear in colon cancer. Methods Flow cytometry was used to detect the percentage of M1 phenotype macrophage, M2 phenotype macrophage and group 1 innate lymphocytes in colon cancer tissue and paracancer healthy colon tissue of AOM/DSS-induced colon cancer mice model. In vitroisolating group 1 innate lymphocytes and inducing bone marrow-derived macrophage to detect the cross-talk when co-cultured. Adoptively transfer or blocking group 1 innate lymphocytes in vivo to explore the role of group 1 innate lymphocytes on tumor-infiltrating macrophage and the tumor growth. Results We found that M1 phenotype macrophage and group 1 innate lymphocytes were down-regulated in colon cancer tissue, and they were positively correlated. Group 1 innate lymphocytes promoted macrophage to classically activated M1 phenotype in vitro, and that could be blocked by anti-IFN-γ. In vivo results showed that the administration of group 1 innate lymphocytes-blocking antibody anti-NK1.1 could decrease the number of M1 phenotype macrophages in tumor tissue of MC38 tumor-bearing mice and promote the tumor growth, while adoptively transferring group 1 innate lymphocytes led to tumor-inhibiting and level of M1 phenotype macrophage up-regulating in MC38 tumor-bearing mice. Conclusions Our studies preliminarily prove that group 1 innate lymphocytes promote the alternative activation of M1 macrophage by secreting IFN-γ and inhibit the progress of colon cancer for the first time, which may provide an insight in the immunotherapy of colon cancer.

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“…Previously studies have shown that ILCs are abundant in intestinal tissue, and ILC2s-derived IL-4 can promote tumorigenesis by polarizing macrophage towards a pro-tumorigenic M2 phenotype [28][29][30] . Furthermore, group 1 innate lymphocytes are characterized by secreting IFN-γ, which can polarize macrophage towards M1 phenotype 31,32 .…”

Section: Group 1 Innate Lymphocytes Is Decreased In Colon Cancer Microenvironment and Is Positive Correlation With M1 Phenotype Macrophagmentioning

confidence: 99%

Group 1 Innate Lymphocyte-Derived IFN-γ Regulates Macrophage Alternative Activation In Colon Cancer

Zhang

et al. 2021

Preprint

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Background: Tumor-associated macrophage (TAM) is an important innate immune cell-subset in tumor microenvironment, and that is also a pivotal orchestrator of tumor-promoting inflammation and tumor progression. Evidence proved that TAMs are up-regulated in a great number of cancers, and most of them are alternative activated M2 phenotype, which greatly promote the progress of cancer diseases. Group 1 innate lymphocytes including conventional NK cells and type 1 innate lymphocytes (ILC1s), are abundant in intestinal tissue, and characterized by expressing transcription factor T-bet and secreting interferon (IFN)-γ, which can promote the macrophage to classically activated anti-tumor M1 phenotype. However, the relationship between these two cell subsets remains unclear in colon cancer. Methods: Flow cytometry was used to detect the percentage of M1 phenotype macrophage, M2 phenotype macrophage and group 1 innate lymphocytes in colon cancer tissue and paracancer healthy colon tissue of AOM/DSS-induced colon cancer mice model. In vitro isolating group 1 innate lymphocytes and inducing bone marrow-derived macrophage to detect the cross-talk when co-cultured. Adoptively transfer or blocking group 1 innate lymphocytes in vivo to investigate the role of group 1 innate lymphocytes on tumor-infiltrating macrophage and the tumor growth. Results: We found that M1 phenotype macrophage and group 1 innate lymphocytes were down-regulated in colon cancer tissue, and they were positively correlated. Group 1 innate lymphocytes promoted macrophage to classically activated M1 phenotype in vitro, and that could be blocked by anti-IFN-γ. In vivo results showed that the administration of group 1 innate lymphocytes-blocking antibody anti-NK1.1 could decrease the number of M1 phenotype macrophage in tumor tissue of MC38 tumor-bearing mice and promote the tumor growth, while adoptively transferring group 1 innate lymphocytes led to tumor-inhibiting and level of M1 phenotype macrophage up-regulating in MC38 tumor-bearing mice. Conclusions: Our studies preliminarily prove that group 1 innate lymphocytes promote the alternative activation of M1 macrophage by secreting IFN-γ to inhibit the progress of colon cancer for the first time, which may provide an insight in the immunotherapy of colon cancer.

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Role of type 2 innate lymphoid cell and its related cytokines in tumor immunity

Cited by 8 publications

References 97 publications

Tumor Cells Inhibit the Activation of ILC2s Through Up-Regulating PD-1 Expression

Tumor Cells Inhibit the Activation of ILC2s Through Up-Regulating PD-1 Expression

Group 1 innate lymphocyte-derived IFN-γ regulates macrophage alternative activation in colon cancer

Group 1 Innate Lymphocyte-Derived IFN-γ Regulates Macrophage Alternative Activation In Colon Cancer

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