Role of ultrasonography in detecting mammographically occult breast carcinoma in women with dense breasts

Corsetti, Vittorio; Ferrari, Aurora; Ghirardi, Marco; Bergonzini, R; Bellarosa, Sergio; Angelini, Osvaldo; Bani, C.; Ciatto, Stefano

doi:10.1007/s11547-006-0040-5

Cited by 137 publications

(99 citation statements)

References 19 publications

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“…However, subjects who underwent ultrasonography for breast cancer screening during their lifetime made up nearly half of the population in Korea. There are reports that breast density appears to be greater in Asian women than in Western women (del Carmen et al, 2007), and ultrasound has been proposed as a supplemental screening test in women with dense breast tissues (Corsetti et al, 2006;Bae et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Cancer Screening in Korea, 2012: Results from the Korean National Cancer Screening Survey

Park

Lee

Choi

et al. 2013

Asian Pacific Journal of Cancer Prevention

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We investigated the cancer screening rates for five types of cancer (stomach, liver, colorectal, breast, and cervix uteri) using data from the Korean National Cancer Screening Survey (KNCSS), which is a nationwide, annual cross-sectional survey. The eligible study population included cancer-free men 40 years of age and older and women 30 years of age and older. The lifetime screening rate and screening rate with recommendation were calculated. The lifetime screening rates for gastric, liver, colorectal, breast, and cervical cancers were 77.9%, 69.9%, 65.8%, 82.9%, and 77.1%, respectively. The screening rates with recommendation were 70.9%, 21.5%, 44.7%, 70.9%, and 67.9%, respectively. The most common reason for all types of cancer was "no symptoms," followed by "lack of time" and "fear of the examination procedure." Efforts to facilitate participation in liver and colorectal cancer screening among Korean men and women are needed.

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Section: Discussionmentioning

confidence: 99%

Cancer Screening in Korea, 2012: Results from the Korean National Cancer Screening Survey

Park

Lee

Choi

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…A substudy of the American College of Radiology Imaging Network (ACRIN) 6666 trial demonstrated a supplemental cancer yield of 18.0 per 1,000 women screened with both MRI and mammography compared with mammography alone after 3 rounds of annual mammography and ultrasound screening (11). For comparison, supplemental cancer yield for screening breast ultrasound ranges from 1.9 to 4.4 per 1,000 women screened (12)(13)(14) and from 1.2 to 2.8 for digital breast tomosynthesis (15)(16)(17)(18). Thus, functional breast imaging approaches, including MRI and BSGI, as adjunct screening modalities outperform the anatomic-based tools of ultrasound and tomosynthesis.…”

Section: See Page 678mentioning

confidence: 99%

Molecular Imaging Approaches for Supplemental Screening in Women at Increased Breast Cancer Risk

Fowler¹

2016

J Nucl Med

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Mammography is an effective screening method that reduces breast cancer mortality (1). However, mammography is not a perfect test and its sensitivity is diminished in women with dense breast tissue (2). For women at increased breast cancer risk, the use of imaging modalities in addition to mammography, termed supplemental screening, can improve the overall cancer detection rate. Current guidelines recommend MRI for supplemental screening in women with greater than 20% lifetime risk of breast cancer (3). For women who cannot tolerate MRI, have mammographically dense breast tissue, or have an intermediate lifetime risk of breast cancer, screening ultrasound can be considered (3). However, these techniques have some drawbacks, which have fueled interest in alternative functional imaging-based methods for supplemental screening in high-risk women. In this issue of The Journal of Nuclear Medicine, Brem et al. investigate the diagnostic performance of a molecular imaging approach for supplemental breast cancer screening (4). See page 678Breast-specific g-imaging (BSGI) is a Food and Drug Administrationapproved radionuclide-based technique that can be used to detect breast cancer (5,6). A high-spatial-resolution, small-field-of-view g-camera detects and localizes g-ray energy emitted by the radiopharmaceutical 99m Tc-methoxyisobutylisonitrile (sestamibi), which preferentially accumulates in malignant breast cells with increased vascular supply and concentration of mitochondria compared with surrounding normal breast tissue. Images are acquired immediately after intravenous injection of the radiopharmaceutical, with the patient seated in standard mammographic views (craniocaudal and mediolateral oblique views) with the breast in mild compression for a total of approximately 40 min. Interpretation of breast-specific g-images follows a standardized lexicon and results in assessment categories and recommendations that parallel those of other imaging modalities outlined by the American College of Radiology Breast Imaging-Reporting and Data System (BI-RADS) (7-9).Although several studies have evaluated the performance of BSGI for diagnosing breast cancer in a heterogeneous mix of clinical indications (10), data regarding the application of BSGI for supplemental screening for women at increased breast cancer risk are sparse. The study by Brem et al. is a single-institution, retrospective review of asymptomatic, increased-risk women undergoing BSGI from 2010 to 2014 whose most recent screening mammogram showed no suspicious abnormalities (4). The study population consisted of 849 women ranging in age from 26 to 83 y with a personal history of treated breast cancer, a family history of breast cancer, a personal history of an atypical or high-risk breast biopsy result, or a known genetic predisposition to breast cancer development. BSGI detected 14 mammographically occult cancers in 849 women, resulting in a supplemental cancer detection rate of 16.5 per 1,000 women screened. Furthermore, mammographic breast density did not affe...

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“…29,30,[140][141][142][143][144][145] Ultrasound has been shown to be particularly useful for detection of non-palpable lesions, 145 invasive cancer ranging from 5 -40mm in size, 29,30 as well as mammographically occult cystic malignant lesions in dense parenchyma. 140,146 Therefore, ultrasound should be recommended as the first choice supplemental modality for dense patients.…”

Section: Imaging the Dense Breastmentioning

confidence: 99%

Breast composition: Measurement and clinical use

Ekpo¹,

Hogg²,

Highnam³

et al. 2015

Radiography

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Breast density is a measure of the extent of radiodense fibroglandular tissue in the breast. The risk of developing breast cancer and the risk of missing cancer at screening rise with higher breast density. In this paper, the historical background to breast density measurement is outlined and current evidence based practice is explained. The relevance of breast density knowledge to mammographic practice and image interpretation is considered in the light of clinical assessment and notification of mammographic breast density (MBD). The current work also discusses risk stratification for decisionmaking regarding screening frequency and better modalities for earlier detection of breast cancer in the dense breast. Automated volumetric approaches are explained while ultrasound, digital breast tomosynthesis, molecular breast imaging, and magnetic resonance imaging are introduced as valuable adjuncts to digital mammography for imaging the dense breast. The work concludes on the important note that screened women should be notified of their breast density, and such notification should be accompanied with clear and adequate information about breast density and cancer risk, strategies associated with lower MBD, as well as best screening intervals and pathways for women with dense breasts. Adoption of these strategies may be crucial to early detection and treatment of cancer and improving survival from the disease.

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Role of ultrasonography in detecting mammographically occult breast carcinoma in women with dense breasts

Cited by 137 publications

References 19 publications

Cancer Screening in Korea, 2012: Results from the Korean National Cancer Screening Survey

Cancer Screening in Korea, 2012: Results from the Korean National Cancer Screening Survey

Molecular Imaging Approaches for Supplemental Screening in Women at Increased Breast Cancer Risk

Breast composition: Measurement and clinical use

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