Role of Ultrasound and Photoacoustic Imaging in Photodynamic Therapy for Cancer

Hester, Scott C.; Kuriakose, Maju; Nguyen, Catherine; Mallidi, Srivalleesha

doi:10.1111/php.13217

Cited by 53 publications

(49 citation statements)

References 140 publications

(180 reference statements)

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“…Ultrasonography, which is cheaper than MRI, may also prove to be useful in terms of assessing PDT efficacy and it may improve PDT mediated outcomes in cancer. Ultrasonography can be implicated in tracking the uptake of PS, destruction of vessels and evaluating the overall tumor responses ( Hester et al, 2020 ). The tissue distribution of the PS can also be evaluated by taking biopsy samples and analyzing the fluorescence ( Moore et al, 2009 ).…”

Section: Clinical Applications Of Photodynamic Therapy In Cancermentioning

confidence: 99%

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

2021

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Photodynamic therapy (PDT) has been used as an anti-tumor treatment method for a long time and photosensitizers (PS) can be used in various types of tumors. Originally, light is an effective tool that has been used in the treatment of diseases for ages. The effects of combination of specific dyes with light illumination was demonstrated at the beginning of 20th century and novel PDT approaches have been developed ever since. Main strategies of current studies are to reduce off-target effects and improve pharmacokinetic properties. Given the high interest and vast literature about the topic, approval of PDT as the first drug/device combination by the FDA should come as no surprise. PDT consists of two stages of treatment, combining light energy with a PS in order to destruct tumor cells after activation by light. In general, PDT has fewer side effects and toxicity than chemotherapy and/or radiotherapy. In addition to the purpose of treatment, several types of PSs can be used for diagnostic purposes for tumors. Such approaches are called photodynamic diagnosis (PDD). In this Review, we provide a general overview of the clinical applications of PDT in cancer, including the diagnostic and therapeutic approaches. Assessment of PDT therapeutic efficacy in the clinic will be discussed, since identifying predictors to determine the response to treatment is crucial. In addition, examples of PDT in various types of tumors will be discussed. Furthermore, combination of PDT with other therapy modalities such as chemotherapy, radiotherapy, surgery and immunotherapy will be emphasized, since such approaches seem to be promising in terms of enhancing effectiveness against tumor. The combination of PDT with other treatments may yield better results than by single treatments. Moreover, the utilization of lower doses in a combination therapy setting may cause less side effects and better results than single therapy. A better understanding of the effectiveness of PDT in a combination setting in the clinic as well as the optimization of such complex multimodal treatments may expand the clinical applications of PDT.

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Section: Clinical Applications Of Photodynamic Therapy In Cancermentioning

confidence: 99%

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

2021

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“…The main biomedical imaging methods are magnetic resonance imaging, CT imaging, and photoacoustic imaging. 201,202 These imaging methods require a contrast agent to enter body tissues or organs to improve image contrast and imaging effect due to the long half-life of nanomaterials in the blood, increasing the accuracy and specificity of imaging. Nowadays, more and more nanomaterials applications are used in bioimaging.…”

Section: Bioimagingmentioning

confidence: 99%

High Stability Au NPs: From Design to Application in Nanomedicine

Zhang¹,

Shao²,

Yue³

et al. 2021

IJN

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In recent years, Au-based nanomaterials are widely used in nanomedicine and biosensors due to their excellent physical and chemical properties. However, these applications require Au NPs to have excellent stability in different environments, such as extreme pH, high temperature, high concentration ions, and various biomatrix. To meet the requirement of multiple applications, many synthetic substances and natural products are used to prepare highly stable Au NPs. Because of this, we aim at offering an update comprehensive summary of preparation high stability Au NPs. In addition, we discuss its application in nanomedicine. The contents of this review are based on a balanced combination of our studies and selected research studies done by worldwide academic groups. First, we address some critical methods for preparing highly stable Au NPs using polymers, including heterocyclic substances, polyethylene glycols, amines, and thiol, then pay attention to natural product progress Au NPs. Then, we sum up the stability of various Au NPs in different stored times, ions solution, pH, temperature, and biomatrix. Finally, the application of Au NPs in nanomedicine, such as drug delivery, bioimaging, photothermal therapy (PTT), clinical diagnosis, nanozyme, and radiotherapy (RT), was addressed concentratedly.

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“…PDT is a photosensitiser (PS)‐based, cancer therapy that creates cytotoxic ROS under exciting light irradiation to destroy cancer cells [39]. Despite its high efficacy and limited side effects, it has shown great potential in cancer treatment [40]. PDT requires the photo‐activation of a molecule of the PS, which is specifically incorporated in neoplastic cells.…”

Section: Pdt Of Cancermentioning

confidence: 99%