Role of ultrasound in early prediction of severity of dengue infection

Abstract

Background: Dengue has become a major international health problem in recent years. As per the World Health Organization, dengue has shown a 30-fold increase globally over the past five decades, and approximately, 50-100 million new infections are estimated to occur annually in more than 100 endemic countries. Objective: To evaluate the sonographic findings in children with dengue fever (DF) and to determine its role in predicting the severity of the disease. Methods: One hundred and twenty dengue serology-positive cases in the age group of 2 months to 18 years were studied. These children were divided into two groups - mild (dengue hemorrhagic fever [DHF] I-II without shock) and severe dengue (DHF III-IV with shock). Sonographic variables of these cases were studied and compared by applying appropriate statistical analysis. Results: Out of 120 cases, gallbladder wall thickness (83.3%) and pericholecystic edema (81.6%) were the most common sonographical findings. When sonographic variables of mild and severe groups compared, significant statistical difference was noted in variables such as ascites, pleural effusion, and perinephric edema with p=0.0015, p=0.0058, p<0.000, respectively. Conclusion: Ultrasound can be used as an adjunct modality in patients with suspected DF to detect early signs suggestive of the disease and also useful tool to predict severity of the disease.

Clinical, haematological and radiological predictors of severe dengue in the paediatric population

“…There was a similar finding in the study by Pothepragada S, et al 25 on univariate analysis. Unlike the present study, a study by Malleshappa K, et al 20 suggested ascites and pleural effusion were not significantly associated with SD. They found perinephric oedema was significantly associated with dengue severity.…”