Role of ultrasound in the detection of recurrent ovarian cancer: a review of the literature

Rosati, A.; Alletti, Salvatore Gueli; Capozzi, Vito Andrea; Mirandola, Mariateresa; Vargiu, Virginia; Fedele, Camilla; Uccella, Stefano; Vascone, Carmine

doi:10.21037/gs-20-357

Cited by 18 publications

(10 citation statements)

References 59 publications

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“…Furthermore, it would be useful to prospectively evaluate the flap viability using ICG and infrared probes with only clinical evaluation to assess whether this new method allows better surgical outcomes. Furthermore, both the complication and the reoperation that could be avoided with this method would certainly improve the patients' quality of life, as reported for other surgeries (33)(34)(35)(36)(37).…”

Section: Discussionmentioning

confidence: 74%

Subcutaneous Vulvar Flap Viability Evaluation With Near-Infrared Probe and Indocyanine Green for Vulvar Cancer Reconstructive Surgery: A Feasible Technique

et al. 2021

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Introduction: Vulvar cancer is a rare condition affecting older women and accounts for 3–5% of all gynecological cancers. Primary surgical treatment involves the removal of a large amount of tissue for which reconstructive surgery is often necessary with a high rate of postoperative complications. Despite several techniques for the evaluation of vulvar flap viability have been proposed, many methods cannot be performed during surgery and require expensive devices often missing in a gynecological clinic. This study aims to verify the feasibility and the safety of the vulvar flap viability evaluation through a near-infrared endoscopic probe and Indocyanine green (ICG) tracer in a small group of patients and to evaluate long-term vulvar flap outcomes.Methods: Patients with primary vulvar cancer who required surgical treatment and subsequent vulvar flap reconstructive surgery were prospectively included in the study. A 25 mg ICG vial diluted in 20 ml of saline solution was intravenously infused before closing the skin edges of the flaps. All patients were given 0.2 mg/kg body weight of intravenous ICG. After 10–15 min, a near-infrared endoscopic probe was used to evaluate the vulvar flap viability.Results: Of the 18 patients who underwent radical vulvectomy for vulvar cancer during the study period, 15 were included in the analysis. All packaged surgical flaps showed tracer uptake on the surgical margin. No intro-operative complications were recorded neither surgery-related nor to dye infusion. No surgical infection, dehiscence, or necrosis was recorded.Conclusions: Vulvar flap viability assessment using Indocyanine green and a laparoscopic infrared probe is a feasible method. All cases included in the analysis showed a dye uptake on the surgical edge of the flap. Further, prospective studies are needed to confirm the method in clinical practice and to evaluate its superiority over simple subjective clinical evaluation.

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Section: Discussionmentioning

confidence: 74%

Subcutaneous Vulvar Flap Viability Evaluation With Near-Infrared Probe and Indocyanine Green for Vulvar Cancer Reconstructive Surgery: A Feasible Technique

et al. 2021

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“…Further, it is worth noting that pelvic exenteration for ovarian cancer would increase the risk of suicide, but not increase the risk of accidental death. These meaningful findings suggest a need in clinical work to detect suicidal ideation as early as possible especially for high-risk subgroups ( 44 , 45 ). We can develop an accurate predictive model to predict the risk of suicide and accidental death in patients and to pay more attention to the high-risk group, and appropriate psychosocial interventions and treatment are also essential, as clinicians could provide psychological counseling to cancer patients to reduce their anxiety, depression and loneliness, and strengthen their confidence to face cancer and help them return to community life, such as psychosocial and emotional support through interpersonal interactions during survivorship care, which potentially reduce the risk of suicide in cancer survivors.…”

Section: Discussionmentioning

confidence: 89%

Suicide and Accidental Death Among Women With Primary Ovarian Cancer: A Population-Based Study

Chen

Xiong

et al. 2022

Front. Med.

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BackgroundWomen with ovarian cancer had the highest suicidal rate among all patients with gynecological malignancies, but no large studies about suicide and accidental death for women with ovarian cancers in detail were conducted. We aimed to determine the relative risk of suicide and accidental death among patients with ovarian cancer to that of the general population, and to identify risk factors associated with suicide and accidental death.MethodsData are from the SEER (surveillance, epidemiology, and end results) cancer registry of women diagnosed with ovarian cancer data from 18 registries for the years 1973–2016. The study population comprised 149,204 patients after inclusion and exclusion criteria were applied. Standardized mortality ratios (SMRs) were calculated and Fine-Gray models were fitted to identify risk factors associated with suicidal and accidental death among cancer patients, with stratifications on demographic and tumor-related characteristics.ResultsWomen with ovarian cancer had a higher risk of suicide and accidental death than the cancer-free group [SMR = 1.86; 95% CI (1.54–2.25) and SMR = 1.54; 95% CI (1.39–1.71)]. Subgroup analysis indicated that only patients with type II epithelial ovarian cancer [SMR = 2.31; 95% CI (1.83–2.91)] had an increased risk of suicide, and those with type I and type II epithelial ovarian cancer [SMR = 1.65; 95% CI (1.39–1.97) and SMR = 1.49; 95% CI (1.30–1.70)] were at a higher risk of accidental death. Patients with ovarian cancer who were younger, white, diagnosed with high-grade, non-metastatic cancer and pelvic exenteration were at a higher risk of suicide. The advanced age, earlier year of diagnosis, and non-metastatic cancer were associated with a higher risk of accidental death. Additionally, pelvic exenteration increased the risk of suicide but not the risk of accidental death among women with primary ovarian cancer.ConclusionsWomen with ovarian cancer had a higher risk of suicide and accidental death compared with the general population. The findings suggested that clinicians should identify high-risk subgroups of ovarian cancer patients for suicide and accidental death as early as possible, with appropriate prevention strategies.

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“…In recurrent OC, MIS is a useful tool to assess the extension of recurrent disease and the feasibility of a surgical treatment [101,102]. In a recent retrospective study, the potential role of MIS has been evaluated in 58 patients with single relapse, platinum sensitive OC, with evidence of safety and optimal secondary cytoreduction [59].…”

Section: Ovarian Cancermentioning

confidence: 99%

Minimally invasive surgery in gynecological cancers: update and systematic review

Scarpelli¹,

Armano²,

Monfardini³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Introduction:In the last decades, the introduction of laparoscopy and, more recently, of robotic surgery, offered new options for surgical treatment also in gynecological malignancies, as an alternative to open surgery. When considering the best surgical treatment option for gynecological malignancies, evidence about safety, feasibility, and oncological outcomes must be taken into account, to offer the best treatment to the patient. The present review aims to provide an updated scenario over the available evidence in the use of minimally invasive surgery (MIS) in gynecological malignancies. Material and methods: An electronic search was performed using the following keywords: 'minimally invasive surgery' and 'gynecology', 'minimally invasive surgery' and 'endometrial cancer', 'minimally invasive surgery' and 'ovarian cancer', 'minimally invasive surgery' and 'cervical cancer'. The agreement about potential relevance was reached by consensus of the researchers and according to PRISMA statement guidelines. Systematic reviews, meta-analyses, clinical trials, and original articles were included in the present review. Results: Fifty-eight studies were considered eligible for the study, 23 studies regarding MIS in endometrial cancer (EC), 19 studies on MIS in ovarian cancer (OC), and 16 studies regarding MIS in cervical cancer (CC). The total of patients enrolled was 180,057, 131,430 in the EC group, 23,774 in the OC groups, and 24,853 in the CC group. Conclusions: According to the available evidence and current clinical practice, MIS is undoubtedly the gold standard for early-stage EC treatment and may represent an acceptable option even in high-risk EC patients. Concerning OC, MIS is a safe and useful tool for staging purposes in advanced-stage disease, and a treatment option only in high volume centres with expert oncologic surgeons. On the contrary, MIS should be abandoned in the context of CC, exception made for well-selected patients, who received adequate counselling about current evidence.

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Role of ultrasound in the detection of recurrent ovarian cancer: a review of the literature

Cited by 18 publications

References 59 publications

Subcutaneous Vulvar Flap Viability Evaluation With Near-Infrared Probe and Indocyanine Green for Vulvar Cancer Reconstructive Surgery: A Feasible Technique

Subcutaneous Vulvar Flap Viability Evaluation With Near-Infrared Probe and Indocyanine Green for Vulvar Cancer Reconstructive Surgery: A Feasible Technique

Suicide and Accidental Death Among Women With Primary Ovarian Cancer: A Population-Based Study

Minimally invasive surgery in gynecological cancers: update and systematic review

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