Role of Upfront Surgery in Advanced Endometrial Cancer at El Shatby Maternity University Hospital

Abstract

Complete cytoreduction surgery followed by appropriate chemotherapy is a valuable option for advanced endometrial cancer. In patients with advanced endometrial cancer, complete cytoreduction with no gross residual disease is associated with superior overall survival outcome and free disease time. Also, patient with stage III endometroid endometrial cancer is associated with superior overall survival outcome and free disease time. Patient selection and accurate clinical staging are prerequisites when adopting upfront surgery strategies.The study was conducted on a group patients diagnosed to have advanced endometrial cancer FIGO stage III/IV attending at El Shatby maternity hospital from January 2020 to December 2021 to assess the effect of upfront surgery on the outcome of the disease. The patients will be diagnosed by D&C biopsy, US and CT. The procedure will be decided according to: Peritoneal cancer index and American society of anaesthesiologist (ASA) physical status. Then all the patients will receive routinely 6 cycles of chemotherapy and followed up for one year to asses recurrence, survival rate and other complication.