Role of Uremic Compounds in Organ Injury

Falaschi, Francesco; Fenoglio, L.; Dellagiovanna, Mirosa; Vecchi, Valentina de; Sepe, Vincenzo; Bressan, Maria Antonietta

doi:10.4172/2161-0959.1000201

Cited by 2 publications

(17 citation statements)

References 41 publications

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“…In addition, the results of this study show that the risk of kidney disease is more evident in patients with severe psoriasis. Our findings are consistent with several reports that have emphasized harmful effects of UA on kidney, the target organ of hyperuricemia (26)(27)(28). Data related to the correlation between serum UA levels and the severity of psoriasis are inconsistent.…”

Section: Discussionsupporting

confidence: 90%

“…In the human body, the progressive increase in the level of uremic toxins exerts a negative impact on all organs, tissues and systems, causing acute and chronic renal dysfunctions, cardiovascular, respiratory and hepatic diseases, atherosclerosis, fibrosis or metabolic alterations (22)(23)(24)(25). The presence of UA derivatives is associated with the induction of specific dysfunctions and the normalization of UA levels results in the resolution of the clinical manifestations (26,27,(44)(45)(46). In terms of chemical structure, uremic toxins are purine, pyrimidine, methylamine, phenyl or indole derivatives, guanidine, polyols, ribonucleosides, peptides, cytokines, advanced glycation end products, advanced lipoxidation end products and reactive carbonyl compounds (26,27,46).…”

Section: Discussionmentioning

confidence: 99%

“…The presence of UA derivatives is associated with the induction of specific dysfunctions and the normalization of UA levels results in the resolution of the clinical manifestations (26,27,(44)(45)(46). In terms of chemical structure, uremic toxins are purine, pyrimidine, methylamine, phenyl or indole derivatives, guanidine, polyols, ribonucleosides, peptides, cytokines, advanced glycation end products, advanced lipoxidation end products and reactive carbonyl compounds (26,27,46).…”

Section: Discussionmentioning

confidence: 99%

“…Purine derivatives pertain to the class of low molecular weight uremic toxins, which frequently accumulate in the body. Low molecular weight uremic toxins are water-soluble compounds with a molecular weight below 0.5 kDa, and consequently are easily removed by dialysis, and do not exert harmful effects on the body (26,27). The most important uremic toxins classified as purine derivatives are: Products resulted from the degradation of purines (adenosine, inosine, xanthine, guanosine, hypoxanthine, guanine, UA), products of guanosine triphosphate catabolism (neopteri n) and oxidative DNA base damage product (8-hydroxy-deoxy-guanosine) (28)(29)(30).…”

Section: Introductionmentioning

confidence: 99%

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Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

et al. 2018

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Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted on a group of 45 patients with psoriasis vulgaris and 45 control cases, monitored over a 5-year period. Alterations of renal function, albumin/creatinine ratio (ACR, mg/g) and UA/creatinine ratio (UACR, mg/mg) were determined in spontaneous urine samples. The status of related-purine derivatives was evaluated by quantification of uric acid (UA, mg/dl), adenosine deaminase (ADA, UI/mg protein), xanthine oxidase (XO, UI/mg protein) and 8-hydroxy-deoxy-guanosine levels (8-OHdG, ng/ml) in serum samples. Compared to the controls, in patients with psoriasis there was an increase in related-purine derivatives levels, which was demonstrated by the elevated serum levels of UA (5.1±0.4 vs. 5.4±1.0, P=0.066), ADA (0.14±0.08 vs. 0.29±0.12, P=0.052), XO (0.22±0.11 vs. 0.42±0.21, P=0.011) and 8-OHdG (3.1±0.05 vs. 8.3±4.7, P=0.002). The serum levels of related-purine derivatives were associated with the severity of psoriasis. In addition, there was a link between the serum levels of related-purine derivatives and markers of renal impairment. There were positive correlations between 8-OHdG and ACR (r=0.452, P=0.028) and between ADA, XO, UA, 8-OHdG and UACR (r=0.297 and P=0.032, r=0.301 and P=0.002, r=0.431 and P=0.027, r=0.508 and P=0.002) and negative correlations between UA, 8-OHdG and the estimated glomerular filtration rate (r=-0.301 and P= 0.036, r=-0.384 and P= 0.002). Thus, severe psoriasis is a risk factor for the development of renal disease.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

et al. 2018

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“…Concentraţia molară a compuşilor uremici va riază de la câţiva picomoli/litru (pentru interleukine) la câţiva micromoli/litru (pentru acidul fenilacetic). (3,5,6)…”

Section: Introducereunclassified

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2015

Ro J Infect Dis.

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Acumularea progresivă a toxinelor uremice în organism exercită o varietate de efecte nocive asupra tuturor organelor, ţesuturilor şi sistemelor. Eliminarea acestor compuşi din organism este un deziderat major al comunităţii ştiinţifice internaţionale. În acest context, obiectivele studiului prezent sunt reprezentate de: clasificarea toxinelor uremice, prezentarea efectelor nocive induse la pacienţii uremici. Această lucrare este orientată în direcţia identificării tulburărilor provocate de toxinele uremice asupra metabolismului şi microcirculaţiei şi găsirea unor noi strategii terapeutice pentru a evita dezvoltarea complicaţiilor la pacienţii uremici.

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Role of Uremic Compounds in Organ Injury

Cited by 2 publications

References 41 publications

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

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