Role of US with Supplemental CT for Localization of Parathyroid Adenomas

Spieth, Michael E.; Gough, John; Kasner, Darcy L.

doi:10.1148/radiol.2233011713

Cited by 6 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although less commonly used for preoperative localization than sonography and CT, MRI provides similar sensitivity to other techniques in the detection of abnormal parathyroid tissue [17,18]. More commonly, MRI is used in patients with persistent or recurrent hyperparathyroidism, in whom it has been shown to be effective in locating remaining abnormal parathyroid tissue [19].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

JTMP

View full text Add to dashboard Cite

Background: Hyperparathyroidism (HPT) is an endocrine disease characterized by a hypercalcemic state due to hyper secretion of parathyroid hormone. Imaging in parathyroid disease (hyperparathyroidism) is aimed at localizing enlarged parathyroid glands after a biochemical diagnosis of hyperparathyroidism has been made. By precisely identifying the number and location of abnormal parathyroid glands, surgical parathyroidectomy can be considered and planned.Objective: This article discusses our experience with hyperparathyroidism, from a radiological point of view, the commonly used techniques for imaging the parathyroid glands and their role in the preoperative evaluation of patients with primary hyperparathyroidism in our tertiary hospital center. The commonly used noninvasive imaging techniques: songraphy, CT, and MRI-their advantages and limitations will be discussed. Material and methods:We have carried out a retrospective study in patients admitted for surgical treatment between January 2009 to December 2013, preoperatively diagnosed with HPT. All patients were hospitalized and prepared for surgery in the Service of Endocrinology and Nephrology where they came from. The data on patient's histories, diagnostic procedures, treatment and complications were acquired from medical reports. In order to detect and locate abnormal parathyroid tissue for preoperative localization study of diseased gland, we have used neck ultrasonography (NUS), computed axial tomography (CT) and magnetic resonance imaging (MRI). Conclusion:The treatment of parathyroid disease is primarily surgical. However, parathyroidectomy would not be successful without accurate preoperative localization of the abnormal gland. This requires skilled radiologists at performing ultrasonography, Ct and other imaging modalities to guide the surgeon in localizing the abnormal gland(s).

show abstract

Section: Discussionmentioning

confidence: 99%

Untitled

2017

JTMP

View full text Add to dashboard Cite

show abstract

“…1 HNMR spectral data are tabulated in the order:m ultiplicity (s, singlet;d ,d oublet;t ,t riplet;q ,q uartet;q uint, quintet;m ,m ultiplet). 1 HNMR spectral data are tabulated in the order:m ultiplicity (s, singlet;d ,d oublet;t ,t riplet;q ,q uartet;q uint, quintet;m ,m ultiplet).…”

Section: Methodsmentioning

confidence: 99%

“…[1] However,c ertain tumoursd on ot have high glucose intake, such as prostate and renal cancer, and tumoursw ith small size and lowc ell density. It is am arker of high glucose metabolism, associated with many tumour types.…”

Section: Introductionmentioning

confidence: 99%

Addressing Chirality in the Structure and Synthesis of [¹⁸F]5‐Fluoroaminosuberic Acid ([¹⁸F]FASu)

Yang

Tam

Čolović

et al. 2017

Chemistry A European J

View full text Add to dashboard Cite

An increasing number of positron emission tomography (PET) radiotracers are being developed that are modelled on various amino acids to better understand disease in a manner that is complementary to traditional glycolysis-targeting [ F]-fluorodeoxyglucose. Since chiral centers are ubiquitous in amino acids, generating an optically pure radiolabeled amino acid is important for patient dose, image quality and understanding the physiology behaviour. Past studies on the radiosynthesis of amino acid radiotracers seldom address the impact of reaction conditions on their chirality. The amino acid PET tracer, [ F]5-fluoroaminosuberic acid ([ F]FASu), has two chiral centers at the 2- and 5-positions and is being developed as a specific tracer for the cystine transporter (system x ), a biomarker for oxidative stress. Herein we report a method for synthesizing pure 2S,5R/S-FASu. We have resolved the 5-position configuration by applying Mosher's method combined with 2D NMR, which has enabled the synthesis of FASu with fully known configuration. Our study serves as an example of a systematic method to identify and characterize amino acid tracers with chiral centers.

show abstract