Role of Vascular Endothelial Growth Factor on Ovarian Function in Bovine

Abstract

Vascular Endothelial Growth Factor (VEGF) plays an important in ovarian function from follicular development to ovulation. It is an angiogeneic factor that stimulates vessel formation and increases vascular permeability to supply nutrition and oxygen to developing follicle. During luteal phase, VEGF expression is required for corpus luteum (CL) development and function. Inhibition of VEGF expression results in abnormal angiogenesis and hence affects ovarian structure. Therefore, understanding the action of VEGF along with action of hormones influencing its expression is necessary to assimilate ovarian pathology.