Role of Vaspin in Human Eating Behaviour

Breitfeld, Jana; Tönjes, Anke; Gast, Marie-Therese; Schleinitz, Dorit; Blüher, Matthias; Stümvoll, Michael; Kovacs, Peter; Böttcher, Yvonne

doi:10.1371/journal.pone.0054140

Cited by 12 publications

(11 citation statements)

References 15 publications

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“…The questionnaire measures the factors (dietary restraint, disinhibition and hunger) influencing individual eating behavior, as described for the Sorbs elsewhere [17].…”

Section: Methodsmentioning

confidence: 99%

TAS2R38 and Its Influence on Smoking Behavior and Glucose Homeostasis in the German Sorbs

et al. 2013

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BackgroundGenetic variants within the bitter taste receptor gene TAS2R38 are associated with sensitivity to bitter taste and are related to eating behavior in the Amish population. Sensitivity to bitter taste is further related to anthropometric traits in an genetically isolated Italian population. We tested whether the TAS2R38 variants (rs713598; rs1726866 and rs10246939) may be related to eating behavior, anthropometric parameters, metabolic traits and consumer goods intake in the German Sorbs.Materials and MethodsThe three SNPs were genotyped in a total cohort of 1007 individuals (male/female: 405/602). The German version of the three-factor eating questionnaire was completed by 548 individuals. Genetic association analyses for smoking behavior, alcohol and coffee intake, eating behavior factors (restraint, disinhibition and hunger) and other metabolic traits were analyzed. Further, by combining the three SNPs we applied comparative haplotype analyses categorizing PAV (proline-alanine-valine) carriers (tasters) vs. homozygous AVI (alanin-valine-isoleucine) carriers (non-tasters).ResultsSignificant associations of genetic variants within TAS2R38 were identified with percentage of body fat, which were driven by associations in women. In men, we observed significant associations with 30 min plasma glucose, and area under the curve for plasma glucose (0–120 min) (all adjusted P≤0.05). Further, we found that carriers of at least one PAV allele show significantly lower cigarette smoking per day (P = 0.002) as well as, albeit non-significant, lower alcohol intake. We did not confirm previously reported associations between genetic variants of TAS2R38 and eating behavior.ConclusionOur data suggest that genetic variation in TAS2R38 is related to individual body composition measures and may further influence consumer goods intake in the Sorbs possibly via individual sensitivity to bitter taste.

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“…The questionnaire measures the factors (dietary restraint, disinhibition and hunger) influencing individual eating behavior, as described for the Sorbs elsewhere [17].…”

Section: Methodsmentioning

confidence: 99%

TAS2R38 and Its Influence on Smoking Behavior and Glucose Homeostasis in the German Sorbs

et al. 2013

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“…An initial study on vaspin and human eating behavior also demonstrated an association of vaspin serum concentrations and eating behavior factors assessed by the German version of the Three‐Factor Eating Questionnaire . Nonetheless, conclusions with regard to the underlying causality remain elusive, and genetic variations of the vaspin gene influencing vaspin serum concentrations were not associated with human eating behavior .…”

Section: Vaspin and Regulation Of Food Intakementioning

confidence: 99%

Vaspin (serpinA12) in obesity, insulin resistance, and inflammation

Heiker

2014

J. Pept. Sci.

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While genome-wide association studies as well as candidate gene studies have revealed a great deal of insight into the contribution of genetics to obesity development and susceptibility, advances in adipose tissue research have substantially changed the understanding of adipose tissue function. Its perception has changed from passive lipid storage tissue to active endocrine organ regulating and modulating whole-body energy homeostasis and metabolism and inflammatory and immune responses by secreting a multitude of bioactive molecules, termed adipokines. The expression of human vaspin (serpinA12) is positively correlated to body mass index and insulin sensitivity and increases glucose tolerance in vivo, suggesting a compensatory role in response to diminished insulin signaling in obesity. Recently, considerable insight has been gained into vaspin structure, function, and specific target tissue-dependent effects, and several lines of evidence suggest vaspin as a promising candidate for drug development for the treatment of obesity-related insulin resistance and inflammation. These will be summarized in this review with a focus on molecular mechanisms and pathways.

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“…For subjects recruitment, the study was advertised by flyers, newspapers, radio and by local general practitioners. 618 Sorbs out of 1046 completed the German version of the three factor eating questionnaire (FEV) which determines the three main eating behavior factors - disinhibition, hunger and restraint as described in detail elsewhere [ 18 , 31 , 32 ]. In the here presented study type 2 diabetes (T2D) was the only exclusion criterion because diabetic individuals usually control their food intake according to specific nutrition plans.…”

Section: Methodsmentioning

confidence: 99%

Genetic variants in AKR1B10 associate with human eating behavior

et al. 2015

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BackgroundThe human Aldoketoreductase 1B10 gene (AKR1B10) encodes one of the enzymes belonging to the family of aldoketoreductases and may be involved in detoxification of nutrients during digestion. Further, AKR1B10 mRNA (messenger ribonucleic acid) expression was diminished in brain regions potentially involved in the regulation of eating behavior in rats which are more sensitive to cocaine and alcohol. We hypothesized that the human AKR1B10 gene may also play a role in the regulation of human eating behavior.ResultsWe investigated the effects of 5 genetic variants of AKR1B10 on human eating behavior among 548 subjects from a German self-contained population, the Sorbs, and in 350 subjects from another independent German cohort. Among the Sorbs, we observed nominal associations with disinhibition at the 5′ untranslated region (5′ UTR) variant rs10232478 and the intragenic variants rs1834150 and rs782881 (all P ≤ 0.05). Further, we detected a relationship of rs1834150 and rs782881 with waist, smoking consumption (rs782881) and coffee consumption (rs1834150) (all P ≤ 0.05). Albeit non-significant, replication analyses revealed similar effect directions for disinhibition at rs1834150 (combined P = 0.0096). Moreover, in the replication cohort we found rs1834150 related to increased restraint scores with a similar direction as in the Sorbs (combined P = 0.0072).ConclusionOur data suggest that genetic variants in the AKR1B10 locus may influence human eating behavior.Electronic supplementary materialThe online version of this article (doi:10.1186/s12863-015-0189-9) contains supplementary material, which is available to authorized users.

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Role of Vaspin in Human Eating Behaviour

Cited by 12 publications

References 15 publications

TAS2R38 and Its Influence on Smoking Behavior and Glucose Homeostasis in the German Sorbs

TAS2R38 and Its Influence on Smoking Behavior and Glucose Homeostasis in the German Sorbs

Vaspin (serpinA12) in obesity, insulin resistance, and inflammation

Genetic variants in AKR1B10 associate with human eating behavior

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