2024
DOI: 10.1038/s44355-024-00013-9
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Role of VEGFA in type 2 diabetes mellitus rats subjected to partial hepatectomy

Carlos Rojano-Alfonso,
Marc Micó-Carnero,
Cristina Maroto-Serrat
et al.

Abstract: The crucial role of vascular endothelial growth Factor A (VEGFA) in healthy rat livers undergoing partial hepatectomy under vascular occlusion (PH + I/R) has been demonstrated. This study evaluates whether this observation can be extrapolated to the presence of type 2 diabetes mellitus (T2DM). VEGFA was pharmacologically modulated and its effects during liver surgery were evaluated. Exogenous VEGFA exacerbated necrosis, with no changes in inflammation, apoptosis, or regeneration compared to PH + I/R. Endogenou… Show more

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