Role of ventral hippocampal NMDA receptors in anxiolytic-like effect of morphine

Motevasseli, Tahmineh; Rezayof, Ameneh; Zarrindast, Mohammad‐Reza; Nayernouri, Touraj

doi:10.1016/j.physbeh.2010.09.013

Cited by 16 publications

(3 citation statements)

References 33 publications

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“…Several lines of evidence suggest that the increase in sucrose intake produced by vHC infusions of APV and the anti- Arc ODN were not likely due to a generalized increase in behavior. For instance, previous reports have shown that vHC infusions of APV either did not affect ( Nascimento Hackl and Carobrez 2007 ; Motevasseli et al 2010 ) or decreased locomotor activity ( Rezvanfard et al 2009 ) in an elevated plus maze. Similarly, the ability of vHC infusions of APV and the anti- Arc ODN to influence conditioned freezing are not due to generalized locomotor activity ( Czerniawski et al 2011 ; Chia and Otto 2013 ).…”

Section: Discussionmentioning

confidence: 96%

Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats

et al. 2021

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Research into the neural mechanisms that underlie higher-order cognitive control of eating behavior suggests that ventral hippocampal (vHC) neurons, which are critical for emotional memory, also inhibit energy intake. We showed previously that optogenetically inhibiting vHC glutamatergic neurons during the early postprandial period, when the memory of the meal would be undergoing consolidation, caused rats to eat their next meal sooner and to eat more during that next meal when the neurons were no longer inhibited. The present research determined whether manipulations known to interfere with synaptic plasticity and memory when given pretraining would increase energy intake when given prior to ingestion. Specifically, we tested the effects of blocking vHC glutamatergic N-methyl-D-aspartate receptors (NMDARs) and activity-regulated cytoskeleton-associated protein (Arc) on sucrose ingestion. The results showed that male rats consumed a larger sucrose meal on days when they were given vHC infusions of the NMDAR antagonist APV or Arc antisense oligodeoxynucleotides than on days when they were given control infusions. The rats did not accommodate for that increase by delaying the onset of their next sucrose meal (i.e., decreased satiety ratio) or by eating less during the next meal. These data suggest that vHC NMDARs and Arc limit meal size and inhibit meal initiation.

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Section: Discussionmentioning

confidence: 96%

Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats

et al. 2021

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“…The drugs used in the study were ketamine and xylazine(Alfasan Chemical Co, Woerden, Holland) for animal anesthesia.Other drugs which were supplied by Tocris, Bristol, UK were: CP94253 Hydrocholoride selective 5-HT1 agonist serotonin receptor; at 0.05, (Paxinos and Watson., 2007;Motevasseli et al, 2010;Nikseresht et al, 2012).…”

Section: Drugsmentioning

confidence: 99%

The role of 5-HT1 receptors of central amygdala upon ACPA-induced anxiolytic-like behaviors and amnesia in rat

2014

Int. J. Biosci.

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Cannabinoidergic as well as serotonergic systems of the amygdala modulates anxiety like behaviors and emotional memory. The effects of cannabinergic system on the anxiety and learning process relate to the central amygdala and its interaction with serotonergic system have not studied yet. With the aim of evaluating the regulating effects of cerotonergic system on the anxiolytic effects of cannabinoids and the possibility of restoring cannabinoid caused amnesia by certonergic system, the current research was conducted using the elevated plusmaze (EPM) test-retest paradigm in the male mice. The bilateral guide-cannulae were implanted to allow intra-CeA microinjection of serotonergic agents. The formation of emotional memory was declined by intra-CeA injection of ACPA, but the anxiety reaction was not affected by the various doses of the mentioned substance.Intra-CeA injection of CP94253 Hydrocholoride, a 5-HT1 serotonin receptor agonist, diminished the formation of emotional memory and the locomotor activity, while 5-HT1 serotonin receptor antagonist, did not influence the anxiety-like behaviors and the emotional memory formation. According to the obtained findings from the current research, it seems that ACPA may trigger anxiolytic-like behaviors and prevent the emotional memory formation, mainly via the activation and deactivation of the CeA 5-HT1 serotonin receptors.

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“…Anxiogenic agents increase the activation of the HPA axis and anxiolytic agents favor the activation of the hypothalamic-pituitary-adrenal (HPA) axis, which modulates the action of corticotroph, corticosterone, and adrenocorticotropic hormones (Grinevich et al, 2012). Morphine administration in rats selectively increased the time spent on and number of entries into the open arms of the elevated plus maze, reflecting an anxiolytic effect of the drug (Hodgson et al, 2008;Motevasseli et al, 2010). However, perinatal exposure to morphine induced hypoactivity of the stress axis to strong stimulation at different postnatal ages (Klausz et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Efeitos da morfina em fases distintas da gestação de ratas: comportamento maternal, desenvolvimento físico e neurocomportamental das proles e biologia molecular dos receptores opióides.

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Role of ventral hippocampal NMDA receptors in anxiolytic-like effect of morphine

Cited by 16 publications

References 33 publications

Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats

Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats

The role of 5-HT1 receptors of central amygdala upon ACPA-induced anxiolytic-like behaviors and amnesia in rat

Efeitos da morfina em fases distintas da gestação de ratas: comportamento maternal, desenvolvimento físico e neurocomportamental das proles e biologia molecular dos receptores opióides.

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