Role of Vessel Microstructure in the Longevity of End-to-Side Grafts

Ramezanpour, Mehdi; Nezami, Farhad Rikhtegar; Ramezanpour, Nahid; Kabinejadian, Foad; Maerefat, Mehdi; Holzapfel, Gerhard; Bull, Joseph L.

doi:10.1115/1.4043873

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…The governing equations and numerical methods used in this study have been previously described in detail 24 . The transient three-dimensional turbulent multiphase flow of blood and ECMO fluid was modeled using compliant walls.…”

Section: Methodsmentioning

confidence: 99%

Simulation of Fluid-Structure Interaction in Extracorporeal Membrane Oxygenation Circulatory Support Systems

Nezami

Ramezanpour

Khodaee

et al. 2021

J. of Cardiovasc. Trans. Res.

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Extracorporeal membrane oxygenation (ECMO) is a vital mechanical circulatory support modality capable of restoring perfusion for the patient in circulatory failure.Despite increasing adoption of ECMO there is incomplete understanding of its effects on systemic hemodynamics and how the vasculature responds to varying levels of continuous retrograde perfusion. To gain further insight into the complex ECMO:failingheart circulation, computational fluid dynamics simulations focused on perfusion distribution and hemodynamic flow patterns were conducted using a patient-derived aorta geometry. Three case scenarios were simulated: (1) healthy control; (2) 90% ECMO-derived perfusion to model profound heart failure; and, (3) 50% ECMO-derived perfusion to model the recovering heart. Fluid-structure interface simulations were performed to quantify systemic pressure and vascular deformation throughout the aorta over the cardiac cycle. ECMO support alters pressure distribution while decreasing shear stress. Insights derived from computational modeling may lead to better understanding of ECMO support and improved patient outcomes.

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Section: Methodsmentioning

confidence: 99%

Simulation of Fluid-Structure Interaction in Extracorporeal Membrane Oxygenation Circulatory Support Systems

Nezami

Ramezanpour

Khodaee

et al. 2021

J. of Cardiovasc. Trans. Res.

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“…Additionally, its incidence rate and ensuing adverse effects are growing in poorer countries 1 . Even though numerous studies in the literature outline various treatment options for patients with CAD [2][3][4][5][6] , the World Health Organization reports that 17.9 million individuals worldwide die from CVDs each year, accounting for 32% of all casualties and >75% of these are contributed from low and middle-income countries.…”

Section: Introductionmentioning

confidence: 99%

Association of Acute Coronary Syndromes with Blood Groups: A Single-Center, Observational Study

Siddiqi¹,

Ghafoor²,

Rana³

et al. 2023

PJMHS

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Background: Evidence suggests an association between ABO blood groups and cardiovascular diseases; particularly acute coronary syndromes, a major reason for hospitalization and mortality. Aim: To investigate the association between ABO blood groups and acute coronary syndrome (ACS) frequency. Study design: Cross-sectional study. Place and duration of study: United Hospital, Karachi from 1st June 2022 to 31st December 2022. Methods: Two hundred and five participants with a diagnosis of ACS were enrolled in this study. A structured questionnaire was used to gather the data regarding the demographics and clinical characteristics of the patients. By utilizing specific antibodies and the agglutination approach, blood types were identified. ECG, coronary angiography, echocardiography and troponin-I were performed on these patients. Results: Blood groups B+ and O+ among ACS patients had the largest prevalence (35.1 and 28.8%, respectively) and there was a significant association between blood groups and the type of MI (p=0.008). The most frequently diagnosed MI was anterior wall myocardial infarction (AWMI), which is highly prevalent among patients with the type A (+ve) blood group. Moreover, the risk factors were equally prevalent among patients of different blood groups. Conclusions: The frequency of ACS and ABO blood type were significantly correlated and there was no statistically significant correlation between any risk factors under study and blood type. Keywords: Acute coronary syndrome, ABO blood type, Risk factors

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“…However, to this day not that many studies were made regarding this problem: in most of researches vessel's wall is simulated as a rigid surface [19,36] or via implementing simple and inaccurate material models such as isotropic shells [23,39,45], neo-Hooke material [18] or Mooney-Rivlin material [50]. Only a few studies used state-of-the-art material models for the modelling of vessel wall, focusing on the several sensitivity studies: Incision length in recipient vessel and insertion angle between artery and graft were analysed in [7] and mismatch between the collagen fibre orientations in comparison with natural bifurcation was analysed in [46].…”

Section: Introductionmentioning

confidence: 99%

Rational choice of modelling assumptions for simulation of blood vessel end-to-side anastomosis

Tagiltsev¹,

Parshin²,

Shutov³

2022

Math. Model. Nat. Phenom.

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Blood vessels exhibit highly nonlinear, anisotropic behaviour with numerous mechanical interactions. Since exact modelling of all involved effects would yield a computationally prohibitive procedure, a practical clinical simulation tool needs to account for a minimum threshold of relevant factors. In this study, we analyse needed modelling assumptions for a reliable simulation of the end-to-side anastomosis. The artery wall is modelled in a geometrically exact setting as a pre-stressed fibre-reinforced composite. The study focuses on the sensitivity analysis of post-anastomosis stress fields concerning the modelling assumptions. Toward that end, a set of full-scale finite element simulations is carried out for three sensitivity cases: (i) The post-operational stresses are estimated with and without taking the residual stresses into account. (ii) Different geometries of the cut in the recipient vessel are examined. (iii) The influence of errors in material stiffness identification on the post-operational stress field is estimated. The studied cases (i)---(iii) have shown a substantial impact of the considered modelling assumptions on the predictive capabilities of the simulation. Approaches to more accurate predictions of post-operational stress distribution are outlined, and a quest for more accurate experimental procedures is made. As a by-product, the occurrence of the pseudo-aneurysm is explained.

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Role of Vessel Microstructure in the Longevity of End-to-Side Grafts

Cited by 6 publications

References 25 publications

Simulation of Fluid-Structure Interaction in Extracorporeal Membrane Oxygenation Circulatory Support Systems

Simulation of Fluid-Structure Interaction in Extracorporeal Membrane Oxygenation Circulatory Support Systems

Association of Acute Coronary Syndromes with Blood Groups: A Single-Center, Observational Study

Rational choice of modelling assumptions for simulation of blood vessel end-to-side anastomosis

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