Role of viral and host factors in interferon based therapy of hepatitis C virus infection

Imran, Muhammad; Manzoor, Sobia; Ashraf, Javed; Khalid, Madiha; Tariq, Muhammad; Khaliq, Hafiza Madeha; Azam, Sikandar

doi:10.1186/1743-422x-10-299

Cited by 31 publications

(17 citation statements)

References 147 publications

(151 reference statements)

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“…Our study showed the HCV sub‐genotype 3a as the most prevalent HCV genotype (56.4%; n = 79/140) with the highest response to interferon‐based therapy (91%; n = 72/79). These results are in concordance with the previous studies .…”

Section: Discussionsupporting

confidence: 94%

Genetic variant of IL28B rs12979860, as predictive marker of interferon‐based therapy in Pakistani population

Imran

Manzoor

Azam

et al. 2015

APMIS

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Hepatitis C virus (HCV) genotypes and genetic variants of interleukin 28B (IL28B) are significantly associated with interferon plus ribavirin treatment of HCV infection. We investigated the distribution of HCV genotypes and single-nucleotide polymorphisms (SNPs) of IL28B (rs12979860 and rs8099917) in Pakistani population. IL28B genotyping was performed by allele-specific PCR and restriction fragment length polymorphism PCR in 140 chronic hepatitis C patients (CHC) and 120 healthy controls. HCV genotype 3 (HCVG3) was the most prevalent genotype, 71.4% (n = 100/140) and with the highest treatment response of 90% (n = 90/100). The overall treatment response of all the HCV genotypes was 82% (n = 115/140). The distribution of IL28B rs12979860CC genotype in treatment responder and non-responder groups was 40.8% (n = 47/115) and 16% (n = 4/25) respectively. IL28B rs12979860CC genotype demonstrated a significant correlation (p = 0.019) with interferon-based therapy of HCV infection. However, there was no observed association of IL28B rs8099917 polymorphism with treatment response in CHC patients (p = 0.264). In conclusion, HCV genotypes and IL28B rs12979860 are predictive markers for the efficiency of interferon plus ribavirin combinational therapy of HCV infection. We recommend the inclusion of testing for these markers in the clinical criteria for decision making for HCV therapy in Pakistani population.

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Section: Discussionsupporting

confidence: 94%

Genetic variant of IL28B rs12979860, as predictive marker of interferon‐based therapy in Pakistani population

Imran

Manzoor

Azam

et al. 2015

APMIS

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“…We excluded 581 studies based on review of the titles and abstracts. We excluded another seven studies20212223242526 because they were not case-control studies, three studies because they did not report genotypes272829, and eight studies3031323334353637 because they did not involve patients with HCC. A further two studies3839 were excluded because they included either patients with only liver cirrhosis or an aggregated patient population with HCC or liver cirrhosis.…”

Section: Resultsmentioning

confidence: 99%

Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma

Zhu

Zhao

et al. 2016

Sci Rep

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This study meta-analyzed the literature on possible association of polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 (IL-18) promoter with risk of hepatocellular carcinoma (HCC). The analysis included 8 case-control studies on the -137 polymorphism (1,318 cases, 2,254 controls) and 7 case-control studies on the -607 polymorphism (1,262 cases, 1,696 controls). None of the five genetic models suggested a significant association between the -137 polymorphism and HCC risk: allelic model, OR 0.99, 95% CI 0.74–1.34, P = 0.97; recessive model, OR 0.98, 95% CI 0.65–1.46, P = 0.91; dominant model, OR 1.35, 95% CI 0.73–2.52, P = 0.34; homozygous model, OR 0.99, 95% CI 0.65–1.49, P = 0.95; heterozygous model, OR 0.99, 95% CI 0.66–1.48, P = 0.94. Similar results were obtained in subgroup analyses of Asian patients, Chinese patients, or patients with hepatitis B virus (HBV)-related HCC. Similar results were also obtained for the -607 polymorphism across the entire study population as well as in the three subgroups. The available evidence suggests no significant association of the -137 or -607 polymorphisms with risk of HCC in general or specifically of HBV-related HCC. These conclusions should be verified in large, well-designed studies.

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“…According to worldwide study, more than two hundred million people are infected by HCV 2. HCV is single-stranded (ss) RNA enveloped virus, which is being placed in family flaviviridae 3.…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology and clinical features of Hepatitis C Virus(HCV) in epidemic areas of Interior Sindh, Pakistan

Bhatti

Manzoor

2016

Pak J Med Sci

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Objective:Highly variable genome of HCV and high prevalence in many geographical areas made it necessary to conduct local population studies. This study has been conducted to show HCV parameters along with clinical features in the local population of interior Sindh, province of Pakistan.Methods:Present study was conducted in from August 2010 to November 2015 in the rural areas of Sindh, Pakistan. All the 31560 screened samples selected for the study were tested by second Generation Enzyme Linked Immunosorbent Assay (ELISA Biokit 480&96).Results:Total 31560 people were screened for HCV and out of these 13.67% (n= 4314) HCV infected patients. When 4314 samples of patients were examined; the anti-HCV was significantly higher in males 2814 (14.98%) than in females 1500 (11.74%) with P value = 0.06. The age of the patients ranged from 18 to 65 years. Out of 4314 HCV samples, 3020 (70%) were of Genotype 3a, 237(5.5%) of Genotype 2a, 108 (2.5%) of Genotype- 1a, 216 (5%) of Genotype 1b, 237 (5.5%) of Genotype 3b and 43 (1%) of Genotype 4. Additionally, 108 (2.5%) had co-infection and 345 (8%) samples showed no result –designated as untypable by the genotyping.Conclusion:This study showed that HCV is most frequently reported disease with genotype 3a being the most prevalent genotype.

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Role of viral and host factors in interferon based therapy of hepatitis C virus infection

Cited by 31 publications

References 147 publications

Genetic variant of IL28B rs12979860, as predictive marker of interferon‐based therapy in Pakistani population

Genetic variant of IL28B rs12979860, as predictive marker of interferon‐based therapy in Pakistani population

Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma

Molecular epidemiology and clinical features of Hepatitis C Virus(HCV) in epidemic areas of Interior Sindh, Pakistan

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