Role of viruses in oral squamous cell carcinoma

Metgud, Rashmi; Astekar, Madhusudan; Verma, Meenal; Sharma, Ashish

doi:10.4081/oncol.2012.208

Cited by 10 publications

(10 citation statements)

References 36 publications

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“…Despite the fact that oral transmission of HPV is unclear, different sexual habits, such as the onset of sexual activity at an earlier age, an increase in the number of partners, and orogenital sex have made HPV an endemic infection [2]. As a result, some studies have shown the role of viruses in head and neck cancer [15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Sexually transmitted infections in oral cavity lesions: Human papillomavirus,Chlamydia trachomatis, and Herpes simplex virus

Mosmann

Talavera

Criscuolo

et al. 2019

Journal of Oral Microbiology

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Objective: Provide evidence of HPV, C. trachomatis, and HSV infection in the oral cavity from patients with different types of stomatological lesions. Materials and Methods: Oral swabs samples were collected from a total of 318 patients. The infectious agents were analyzed using the PCR technique. HPV genotyping and HSV type were studied using the RFLP method. Results: We studied 137 benign lesions (B), 96 potentially malignant disorders (PMD) and 85 oral squamous cell carcinomas (OSCC). The prevalence of HPV was 34%. The most frequently genotypes detected were 6 low risk and 16 high risk. The prevalence of C. trachomatis was 16% and HSV 3%. Co-infections were detected mostly in benign lesions as following: HPV-C. trachomatis in 4%, C. trachomatis-HSV in 1.8% and HPV-HSV in 0.3%. Conclusion: This report is the first contribution to the identification and genotype characterization of HPV in a scenario little studied in our area, and it also contributes to improving our understanding on sexually transmitted infectious agents and their associations with the oral cavity. Besides, we detect the presence of C. trachomatis and HSV and co-infection with HPV in the oral cavity, which they should be taken into account for diagnostic and treatment purposes.

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Section: Discussionmentioning

confidence: 99%

Sexually transmitted infections in oral cavity lesions: Human papillomavirus,Chlamydia trachomatis, and Herpes simplex virus

Mosmann

Talavera

Criscuolo

et al. 2019

Journal of Oral Microbiology

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“…Oral squamous cell carcinoma (OSCC) is the sixth most common cancer originating from squamous cells of oral cavity, resulting in high annual morbidity and mortality worldwide. OSCC is a subtype of head and neck cancer that contributes up to 90% of total head and neck cancer .…”

Section: Introductionmentioning

confidence: 99%

Association of Epstein‐Barr virus infection with oral squamous cell carcinoma in a case–control study

Acharya

Ekalaksananan

Vatanasapt

et al. 2014

J Oral Pathology Medicine

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“…The role of herpes simplex virus 1 in the occurrence of SCC is not yet clearly elucidated in literature. However, hypotheses suggest that Herpes Simplex Virus (HSV) infection would promote a state of chronic inflammation responsible for the malignant degeneration of cells, and also that the transient acquisition of a complete or incomplete viral genome can be sufficient to induce malignant transformation of host cells in vivo, resulting in the development of neoplastic cells [8]. The vesicular and ulcerative aspect of the lesion is the most commonly form found in literature and thus represents the most severe aspect found in HIV-positive patients [2,9].…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma of the Lower Lip Complicating a Recurrent Labial Herpes During HIV Infection: a Case Report

2020

IJCED

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Introduction: Squamous cell carcinoma (SCC) is the main cancer of lips; it is increasingly diagnosed in HIV-positive patients. In most cases, there are factors that promote his occurrence. We report a case of an HIV-positive woman with SCC of the lower lip complicating recurrent labial herpes. Medical observation: It was a case of a 40-year-old female received in consultation for a painful and ulcerous lesion of her lip lasting 5 months. She was a HIV-positive patient diagnose since 2007 and on Highly Active Antiretroviral Therapy since that time. She was taking alcohol, was exposed to sunlight regularly, and had presented many episodes of labial herpes in the past. On clinical examination she had a painful ulcero-crustal medallion measuring 2.5 centimeters in diameter, with a papular edge of pearlescent appearance of the lower lip. Given this clinical picture, the diagnosis of chronic decaying herpes labialis with in differential an epithelial tumor (in particular a squamous cell carcinoma of the lower lip) was mentioned. After surgical excision, an anatomopathological analysis of the part confirmed the diagnosis of squamous cell carcinoma. At the time of diagnosis, the patient had a respective CD4 and CD8 level of 939 and 964 cells / mm3 . The evolution was marked 6 weeks later by the scarring with complete epithelialization of the site of the lesion. Conclusion: SCC of the lips is a frequent cancer occurring during HIV infection; there are many risk factors which promote his occurrence. Earlier the treatment is instituted, better is the prognosis.

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Role of viruses in oral squamous cell carcinoma

Cited by 10 publications

References 36 publications

Sexually transmitted infections in oral cavity lesions: Human papillomavirus,Chlamydia trachomatis, and Herpes simplex virus

Sexually transmitted infections in oral cavity lesions: Human papillomavirus,Chlamydia trachomatis, and Herpes simplex virus

Association of Epstein‐Barr virus infection with oral squamous cell carcinoma in a case–control study

Squamous Cell Carcinoma of the Lower Lip Complicating a Recurrent Labial Herpes During HIV Infection: a Case Report

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