Role of Vitamin C in Osteoporosis Development and Treatment—A Literature Review

Brzezińska, Olga; Łukasik, Zuzanna; Makowska, Joanna; Walczak, Konrad

doi:10.3390/nu12082394

Cited by 39 publications

(41 citation statements)

References 87 publications

(186 reference statements)

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“…Healthy, well-balanced nutrition can play an important role in the prevention and pathogenesis of osteoporosis, and in support of pharmacological therapy [6]. Several factors contribute to the development of osteoporosis in post-menopausal women, among which, low-grade inflammation, poor dietary habits, and sedentary and unhealthy lifestyles, such as smoking and alcohol consumption [7,8].…”

Section: Introductionmentioning

confidence: 99%

The Mediterranean Diet in Osteoporosis Prevention: An Insight in a Peri- and Post-Menopausal Population

et al. 2021

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Osteoporosis represent a widespread public health problem. The management and prevention of osteoporosis and related low energy fractures start with a correct lifestyle and proper nutrition. Several different nutrients are essential for bone and mineral metabolism, especially calcium. Nevertheless, a well-balanced nutrition, such as Mediterranean diet (MD), proved to be beneficial for several chronic diseases and also fragility fractures resulted lower in the Mediterranean area. A prospective observational study in a population of two hundred peri- and post-menopausal women (aged 30–80 years) was developed at Careggi hospital, Florence. Both MD adherence and dietary calcium intake were evaluated in occasion of a “first visit” and a “follow-up” visit, through validated questionnaires. From a descriptive point of view, although not statistically significant, in both visits a slight increase in calcium intake was observed for high adherence to MD diet. Moreover, a short nutritional interview (20 min) was applied in our population and demonstrated to be sufficient to significantly improve MD adherence level (mean score at T0 = 6.98 ± 1.74 and T1 = 7.53 ± 1.68), opening promising paths in osteoporosis prevention.

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Section: Introductionmentioning

confidence: 99%

The Mediterranean Diet in Osteoporosis Prevention: An Insight in a Peri- and Post-Menopausal Population

et al. 2021

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“…Vitamin C deficiency is known to delay healing after bone fractures 16 and a higher dietary vitamin C intake is related to a reduction in femoral neck bone mineral density loss 17 . Consistently, several epidemiological 18 , 19 and review 20 studies have identified a positive association between bone mineral density and dietary vitamin C intake.…”

Section: Introductionmentioning

confidence: 53%

A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients

Hung

Chiang

et al. 2021

Sci Rep

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This meta-analysis aimed at investigating the impact of oral vitamin C supplementation on the post-procedural recovery of orthopedic patients, including functional outcomes and complex regional pain syndrome type I (CRPS I). Literature search using the Medline, Cochrane Library, and Embase databases from inception till March 2021 identified seven eligible randomized controlled trials with 1,361 participants. Forest plot revealed no significant difference in the functional outcomes at 6–12 months [standardized mean difference (SMD) = −0.00, 95% CI − 0.19 to 0.18, 467 patients], risk of overall complications (RR = 0.98, 95% CI 0.68 to 1.39, 426 patients), and pain severity at 3–6 months (SMD = − 0.18, 95% CI − 0.49 to 0.12, 486 patients) between patients with and without oral vitamin C supplementation. Pooled analysis showed that vitamin C treatment reduced the risk of CRPS I regardless of dosage (RR = 0.46, 95% CI 0.25 to 0.85, 1143 patients). In conclusion, the current meta-analysis demonstrated that oral vitamin C supplementation may reduce the risk of complex regional pain syndrome type I but did not improve the functional outcomes in orthopedic patients. Nevertheless, because of the small number of trials included in the present study, further large-scale clinical studies are warranted to support our findings.

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“…Vitamin C may not only exhibit antioxidant properties but may also exhibit prooxidant traits when consumed at higher concentrations, as the prior study found that 500 mg/day of vitamin C supplementation in men and women (aged between 17 and 49) for 6 weeks could promote oxidative DNA damage [ 49 ], and this may also be relevant to osteoporosis [ 45 ]. Furthermore, vitamin C at first was reported to act as an oxidant during osteoclastogenesis, and the oxidative stress accelerated osteoclast formation, but it caused osteoclast death at a later stage [ 50 , 51 ]. The main sources of vitamin C in the human diet are citrus fruits, pepper and kiwifruit, as well as cabbage, broccoli, kale or tomatoes [ 52 ].…”

Section: Bone and Osteoporosismentioning

confidence: 99%

Functional Food for Elderly High in Antioxidant and Chicken Eggshell Calcium to Reduce the Risk of Osteoporosis—A Narrative Review

Arnold

Rajagukguk

Gramza‐Michałowska

2021

Foods

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The elderly population is increasing globally and is predicted to reach 1.5 billion in 2050. The quality of life of the elderly must be concerned, for example, with developing functional food for the elderly. In this article, the development of functional food to reduce the risk of osteoporosis in the elderly is reviewed. Oxidative stress is one of the factors which accelerates osteoporosis. Various antioxidants, including vitamin C, vitamin E, polyphenols, or lycopene, have been proven by former studies to have antioxidant activity, therefore, could reduce the risk of osteoporosis. Additionally, the application of eggshell powder in various food products has been reported to improve calcium intake, and its usage is environmentally sustainable as this could contribute to reducing food waste. The application of both antioxidants and calcium could be a good combination, but the amount of some antioxidants must be concerned so it would not interfere with the bioavailability of calcium. Therefore, this review aims to explore the functional food for the elderly to reduce the risk of osteoporosis, particularly with antioxidants and calcium from chicken eggshells. The eating preference and dietary pattern of the elderly are also considered to determine the suitable form of functional food for the elderly. The results presented in the study may be the basis for the development of new calcium-enriched food products for the elderly.

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Role of Vitamin C in Osteoporosis Development and Treatment—A Literature Review

Cited by 39 publications

References 87 publications

The Mediterranean Diet in Osteoporosis Prevention: An Insight in a Peri- and Post-Menopausal Population

The Mediterranean Diet in Osteoporosis Prevention: An Insight in a Peri- and Post-Menopausal Population

A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients

Functional Food for Elderly High in Antioxidant and Chicken Eggshell Calcium to Reduce the Risk of Osteoporosis—A Narrative Review

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