Role of Vitamin - D Deficiency in Term Neonates with late-onset sepsis at Benha University Hospitals

Abstract

Background: Neonatal In both full-term and premature newborns, sepsis is the leading cause of death and illness. Aim: The purpose of this research was to determine whether or not there is a correlation between vitamin-D status and LOS in fullterm infants. Methods: Eighty participants were randomly assigned to one of two groups: Group I (LOS group) consisted of 40 newborns diagnosed with LOS at presentation between 72 and 28 days of age. Forty full-term, healthy newborns made comprised Group II, the control group. All of the newborns involved in the study had a thorough history taken, a comprehensive clinical examination performed, and several laboratory tests performed, including a complete blood count, Creactive protein, Random blood sugar, blood culture, urine culture, and CSF analysis and culture. The 25-hydroxyvitamin D (25-OH-D) levels were measured quantitatively using an auto chemiluminescence immunoassay instrument (Maccura i1000). Results:The results showed that the LOS group had significantly lower vitamin D levels than the control group, as well as a significantly greater prevalence of vitamin D insufficiency and severe deficiency. Patients with a maternal history of diabetes, hypertension, or recurrent urinary tract infections also had lower vitamin D levels than their rural counterparts. Vitamin D levels were positively correlated with the APGAR score, while total bilirubin levels were inversely correlated with Vitamin D levels. conclusion: In conclusion, term newborns with LOS had lower levels of 25-hydroxyvitamin D than the control group. Patients from metropolitan regions, as well as those with a maternal history of diabetes, hypertension, or recurrent urinary tract infections, had significantly lower vitamin D levels.