Role of vitamin D and vitamin D receptor gene polymorphisms on residual beta cell function in children with type 1 diabetes mellitus

Habibian, Narges; Amoli, Mahsa M.; Abbasi, Farzaneh; Rabbani, Ali; Alipour, Abbas; Sayarifard, Fatemeh; Rostami, Parastoo; Dizaji, Somayeh Parichehreh; Saadati, Babak; Setoodeh, Aria

doi:10.1016/j.pharep.2018.12.012

Cited by 21 publications

(18 citation statements)

References 31 publications

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“…In addition, higher cord blood 25(OH)D levels at birth have recently been shown to predict a lower risk of developing T1D in children homozygous for the VDR rs11568820 G/G genotype [125]. Several studies have demonstrated an association between increased T1D risk and certain SNPs in VDR (especially Bsm-I and Fok-I), although the exact alleles that most predispose to T1D development remain still controversial [128,129,130,131,132,133,134]. Finally, Habibian et al [134] showed that sufficient serum 25(OH)D levels (≥30 ng/mL) and certain genotypes of TaqI and BsmI SNPs in VDR were significantly associated with higher levels of stimulated C-peptide in patients with new-onset T1D, potentially resulting in a greater preservation of residual beta-cell mass and function.…”

Section: The Role Of Polymorphisms Of Vitamin D Metabolism Genes Imentioning

confidence: 99%

Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes

et al. 2019

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Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence of T1D is increasing worldwide, thus prompting researchers to investigate novel immunomodulatory strategies to halt autoimmunity and modify disease progression. T1D is considered as a multifactorial disease, in which genetic predisposition and environmental factors interact to promote the triggering of autoimmune responses against beta cells. Over the last decades, it has become clear that vitamin D exerts anti-inflammatory and immunomodulatory effects, apart from its well-established role in the regulation of calcium homeostasis and bone metabolism. Importantly, the global incidence of vitamin D deficiency is also dramatically increasing and epidemiologic evidence suggests an involvement of vitamin D deficiency in T1D pathogenesis. Polymorphisms in genes critical for vitamin D metabolism have also been shown to modulate the risk of T1D. Moreover, several studies have investigated the role of vitamin D (in different doses and formulations) as a potential adjuvant immunomodulatory therapy in patients with new-onset and established T1D. This review aims to present the current knowledge on the immunomodulatory effects of vitamin D and summarize the clinical interventional studies investigating its use for prevention or treatment of T1D.

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Section: The Role Of Polymorphisms Of Vitamin D Metabolism Genes Imentioning

confidence: 99%

Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes

et al. 2019

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“…To the best of our knowledge, no previous studies have addressed the quantitative association between serum 25(OH)D concentration of 100-150 nmol/L to the significantly lower risk of T1DM. Functionally, sufficient serum 25(OH)D concentration can preserve the activity of residual pancreatic β-cells and insulin secretion [44]. Meanwhile, a past study reported that the serum 25 (OH)D concentration was negatively associated with insulin resistance in patients with T1DM [45].…”

Section: Discussionmentioning

confidence: 99%

A dose–response meta-analysis between serum concentration of 25-hydroxy vitamin D and risk of type 1 diabetes mellitus

et al. 2020

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It remains debatable whether vitamin D plays any role as a risk factor for type 1 diabetes mellitus (T1DM). We have summarized the effect of circulating 25-hydroxy vitamin D [25(OH)D] concentration on the risk of developing T1DM via a dose–response meta-analysis. We undertook a database search on PubMed, Embase, and Cochrane Library from inception to January 2020. A meta-analysis based on random-effects model was applied. Subgroup analysis and meta-regression were performed to inspect the source of heterogeneity. Dose–response data were examined using the generalized least squares trend estimation method. This study was registered with the PROSPERO (ID: CRD42020166174). In total, 16 studies including 10,605 participants (3913 case patients) were included. The pooled odds ratios (OR) and 95% confidence intervals (95% CI) for the highest versus the lowest 25(OH)D concentration was 0.39 (0.27, 0.57), with a high heterogeneity (I2 = 76.7%, P < 0.001). Meta-regression analysis identified latitude (P = 0.02), adjustment for gender (P = 0.001), and 25(OH)D stratification (P < 0.001) as sources of heterogeneity. Furthermore, the nonlinear dose–response analysis determined the OR (95% CI) of T1DM to be 0.91 (0.90, 0.93) per 10 nmol/L increase in the 25(OH)D concentration. A ‘U’-shaped association was found between serum 25(OH)D concentration and risk of T1DM. The present study highlights the significant inverse association between the circulating 25(OH)D concentration and the risk of T1DM.

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“…The pathogenetic role of vitamin D in T1DM onset is debated. The Type 1 Diabetes Genetic Consortium, which genotypically characterized 38 single nucleotide polymorphisms (SNPs) in more than 1500 families with T1DM, did not observe correlations between SNPs in the VDR and T1DM [138], even if associations between some VDR polymorphisms (BsmI, FokI, TaqI, ApaI) and T1DM have been pinpointed in several population studies [139][140][141][142][143][144][145][146][147][148]. In 2017, Sahin OA et al [149] published a meta-analysis, with the aim to evaluate the relationship between ApaI, BsmI, FokI, and TaqI polymorphisms of VDR and T1DM in children.…”

Section: Type 1 Diabetes Mellitusmentioning

confidence: 99%

Pathophysiological Role and Therapeutic Implications of Vitamin D in Autoimmunity: Focus on Chronic Autoimmune Diseases

et al. 2020

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Vitamin D is a pleiotropic secosteroid yielding multiple actions in human physiology. Besides the canonical regulatory activity on bone metabolism, several non-classical actions have been described and the ability of vitamin D to partake in the regulation of the immune system is particularly interesting, though far stronger and convincing evidence has been collected in in vitro as compared to in vivo studies. Whether vitamin D is able to regulate at physiological concentrations the human immune system remains unproven to date. Consequently, it is not established if vitamin D status is a factor involved in the pathogenesis of immune-mediated diseases and if cholecalciferol supplementation acts as an adjuvant for autoimmune diseases. The development of autoimmunity is a heterogeneous process, which may involve different organs and systems with a wide range of clinical implications. In the present paper, we reviewed the current evidences regarding vitamin D role in the pathogenesis and management of different autoimmune diseases.

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Role of vitamin D and vitamin D receptor gene polymorphisms on residual beta cell function in children with type 1 diabetes mellitus

Cited by 21 publications

References 31 publications

Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes

Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes

A dose–response meta-analysis between serum concentration of 25-hydroxy vitamin D and risk of type 1 diabetes mellitus

Pathophysiological Role and Therapeutic Implications of Vitamin D in Autoimmunity: Focus on Chronic Autoimmune Diseases

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