Role of vitamin D deficiency and comorbidities in COVID-19

Alberca, Gabriela Gama Freire; Alberca, Ricardo Wesley

doi:10.5501/wjv.v11.i1.85

Cited by 4 publications

(1 citation statement)

References 47 publications

(45 reference statements)

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“…168,169 Our cause-effect analysis methodology addresses the limitations arising from the use of confidence in connectivity criteria and topological arguments for constructing and interpreting protein interaction networks relevant to vitamin D pharmacology. We have validated the relevance of the core VDR interactome by (1) using functional evidence to demonstrate that the proteins shown in Figure 3 are key drivers of vitamin D pharmacology, (2) identifying that perturbations of the regulatory scheme precipitate 590 vitamin D deficiencyassociated comorbidities (Figure 4), 170 and (3) that diseases identified using the core VDR interactome as the mechanism of action rationale express the characteristic physical abnormalities associated with vitamin D deficiency (Figures 5A and 5B). These observations illustrate that information flow-based, cause-effect analysis using protein swarms to integrate dynamic properties of proteins increases confidence in interactome construction for using proteomics data to influence decision-making.…”

Section: Discussionmentioning

confidence: 96%

Vitamin D Deficiency-Associated Comorbidities: A Protein Network Dynamics Perspective

Fliri¹,

Kajiji²

2023

MRAJ

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Vitamin D deficiency has been linked to numerous comorbid diseases. Despite this recognition, the effectiveness of vitamin D supplementation in improving clinical outcomes remains uncertain. To shed light on the underlying cause-effect relationships and molecular mechanisms involved, we analyzed effects of over 4000 diseases on information transfers between biological processes in human tissues. Spectral clustering of the data generated identified relationships between disease phenotypes and perturbations of protein network-network interactions mediating information transfers in tissues. Examination of these relationships discovered an integrated regulatory scheme involving interactions between 188 proteins responsive to vitamin D (vitamin D interactome). Functional analysis established a central role of fifteen proteins (core vitamin D interactome) in vitamin D pharmacology and their involvement in multiple reciprocal feedback loops. Identification of functions affected by this core regulatory framework provides new insights into relationships between vitamin D deficiency-associated comorbidities, epigenetic regulation of vitamin D pharmacology, and impact of mutations on disease. Recognition of these functional relationships suggests that vitamin D associated comorbidities may not be fully treatable by vitamin D supplementation alone. Further examination of consequences of perturbations of protein interactions within the core vitamin D interactome identified 590 morbidities exhibiting physical changes co-expressed in vitamin D deficiency. Further analysis revealed that these comorbidities can be differentiated based on cause-effect relationships defined by characteristic patterns of physical abnormalities and effects on protein network interactions. These findings demonstrate the utility of systems biology-based cause-effect analyses to unravel complex relationships involving multiple diseases and multiple biological processes; thereby providing a more comprehensive understanding of comorbidities and the impact of vitamin D deficiency on health. Article Details How to Cite

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Section: Discussionmentioning

confidence: 96%

Vitamin D Deficiency-Associated Comorbidities: A Protein Network Dynamics Perspective

Fliri¹,

Kajiji²

2023

MRAJ

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Influence of vitamins D and C on metabolic processes in illness with COVID-19

UTKA,

LENO,

FEDEVYCH

2023

Eksp.Klin.fiziol.biohim

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Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years

Pavel-Tanasa

Constantinescu²,

Cianga³

et al. 2022

Front. Immunol.

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to a global health outbreak known as the COVID-19 pandemic which has been lasting since March 2020. Vaccine became accessible to people only at the beginning of 2021 which greatly helped reducing the mortality rate and severity of COVID-19 infection afterwards. The efficacy of vaccines was not fully known and studies documenting the immune responses following vaccination are continuing to emerge. Recent evidence indicate that natural infection prior vaccination may improve the antibody and cellular immune responses, while little is known about the factors influencing those processes. Here we investigated the antibody responses following BNT162b2 vaccination in relation to previous-infection status and age, and searched for possible biomarkers associated with the observed changes in immune responses. We found that the previous-infection status caused at least 8-times increase in the antibody titres, effect that was weaker in people over 60 years old and unaltered by the vitamin D serum levels. Furthermore, we identified adiponectin to positively associate with antibody responses and negatively correlate with pro-inflammatory molecules (MCP-1, factor D, CRP, PAI-1), especially in previously-infected individuals.

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Role of vitamin D deficiency and comorbidities in COVID-19

Cited by 4 publications

References 47 publications

Vitamin D Deficiency-Associated Comorbidities: A Protein Network Dynamics Perspective

Vitamin D Deficiency-Associated Comorbidities: A Protein Network Dynamics Perspective

Influence of vitamins D and C on metabolic processes in illness with COVID-19

Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years

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