Role of Vitamin D in Amyloid clearance via LRP-1 upregulation in Alzheimer’s disease: A potential therapeutic target?

Patel, Parmi; Shah, Jigna

doi:10.1016/j.jchemneu.2017.06.007

Cited by 38 publications

(23 citation statements)

References 65 publications

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“…Other major risk factors for AD include gender, family history, genetics, and head trauma, low educational attainment and environmental factors. There is accumulating evidence suggesting a significant association between vitamin D and AD [ 167 , 168 , 169 , 170 ]. In vitro, vitamin D stimulates macrophages which increase the clearance of Aβ plaques [ 171 , 172 ], reduces amyloid-induced cytotoxicity and apoptosis in primary cortical neurons [ 173 ], and influences Aβ stimulation of induced nitric oxide synthase (iNOS), which contributes to modulate the inflammatory process related to AD [ 174 ].…”

Section: Alzheimer’s Disease and Vitamin Dmentioning

confidence: 99%

Vitamin D and Neurological Diseases: An Endocrine View

Somma

Scarano

Barrea³

et al. 2017

IJMS

191

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Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the “non-calcemic” actions of vitamin D, which are associated with the maintenance of glucose homeostasis, cardiovascular morbidity, autoimmunity, inflammation, and cancer. In parallel, growing evidence has recognized that a multimodal association links vitamin D system to brain development, functions and diseases. With vitamin D deficiency reaching epidemic proportions worldwide, there is now concern that optimal levels of vitamin D in the bloodstream are also necessary to preserve the neurological development and protect the adult brain. The aim of this review is to highlight the relationship between vitamin D and neurological diseases.

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Section: Alzheimer’s Disease and Vitamin Dmentioning

confidence: 99%

Vitamin D and Neurological Diseases: An Endocrine View

Somma

Scarano

Barrea³

et al. 2017

IJMS

191

View full text Add to dashboard Cite

show abstract

“…Similarly, it was demonstrated that TREM2 (the triggering receptor expressed on myeloid cells 2) directly binds AβOs in nanomolar affinity and modulates microglial formation [123]. Certain nuclear receptors, such as the vitamin D receptors, are also linked to AβO toxicity and AD pathology [124].…”

mentioning

confidence: 99%

Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis

2020

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The structural polymorphism and the physiological and pathophysiological roles of two important proteins, β-amyloid (Aβ) and tau, that play a key role in Alzheimer’s disease (AD) are reviewed. Recent results demonstrate that monomeric Aβ has important physiological functions. Toxic oligomeric Aβ assemblies (AβOs) may play a decisive role in AD pathogenesis. The polymorph fibrillar Aβ (fAβ) form has a very ordered cross-β structure and is assumed to be non-toxic. Tau monomers also have several important physiological actions; however, their oligomerization leads to toxic oligomers (TauOs). Further polymerization results in probably non-toxic fibrillar structures, among others neurofibrillary tangles (NFTs). Their structure was determined by cryo-electron microscopy at atomic level. Both AβOs and TauOs may initiate neurodegenerative processes, and their interactions and crosstalk determine the pathophysiological changes in AD. TauOs (perhaps also AβO) have prionoid character, and they may be responsible for cell-to-cell spreading of the disease. Both extra- and intracellular AβOs and TauOs (and not the previously hypothesized amyloid plaques and NFTs) may represent the novel targets of AD drug research.

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“…Even though its synthesis is stimulated primarily by ultraviolet radiation, it can also be obtained from dietary sources such as fish [58]. Vitamin D can be considered as a dementia-preventing agent because of its anti-inflammatory and anti-amyloid properties, such as enhanced Aβ clearance from the brain, through phagocytosis but also have an impact of Aβ production and enzymatic degradation [59]. It inhibits TNF-α and interleukin-6 production in the microglia as well as reduces Aβ levels in the hippocampus and promotes its phagocytosis by macrophages.…”

Section: Omega-3 Fatty Acids and Fat-soluble Vitaminsmentioning

confidence: 99%

“…It inhibits TNF-α and interleukin-6 production in the microglia as well as reduces Aβ levels in the hippocampus and promotes its phagocytosis by macrophages. Vitamin D also influences calcium homeostasis, which is often disturbed in neurodegenerative diseases [59,60]. Morello et al [61] investigated the effects of this vitamin on mice expressing human APP.…”

Section: Omega-3 Fatty Acids and Fat-soluble Vitaminsmentioning

confidence: 99%

The Role of Selected Bioactive Compounds in the Prevention of Alzheimer’s Disease

Grodzicki

Dziendzikowska

2020

Antioxidants

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Neurodegeneration is a feature of many debilitating, incurable age-dependent diseases that affect the nervous system and represent a major threat to the health of elderly persons. Because of the ongoing process of aging experienced by modern societies, the increasing prevalence of neurodegenerative diseases is becoming a global public health concern. A major cause of age-related dementia is Alzheimer’s disease (AD). Currently, there are no effective therapies to slow, stop, or reverse the progression of this disease. However, many studies have suggested that modification of lifestyle factors, such as the introduction of an appropriate diet, can delay or prevent the onset of this disorder. Diet is currently considered to be a crucial factor in controlling health and protecting oneself against oxidative stress and chronic inflammation, and thus against chronic degenerative diseases. A large number of bioactive food compounds may influence the pathological mechanisms underlying AD. Among them, phenolic compounds, omega-3 fatty acids, fat-soluble vitamins, isothiocyanates, and carotenoids seem to be promising. They act not only as antioxidant and anti-inflammatory agents, but also as active modulators of the pathological molecular mechanisms that play a role in AD development, including the formation of amyloid plaques and tau tangles, the main hallmarks of AD pathology. In vivo animal model studies as well as clinical and epidemiological research suggest that nutritional intervention has a positive effect on the health of older people and may prevent age-related cognitive decline, especially when the diet contains more than one bioactive nutrient. The Mediterranean diet and in particular its combination with Dietary Approaches to Stop Hypertension, which is called the MIND diet, are nutritional patterns based on many products rich in bioactive compounds that appear to be the most effective in preventing neurodegeneration. The present review gathers evidence that supports the neuroprotective effect of bioactive substances.

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Role of Vitamin D in Amyloid clearance via LRP-1 upregulation in Alzheimer’s disease: A potential therapeutic target?

Cited by 38 publications

References 65 publications

Vitamin D and Neurological Diseases: An Endocrine View

Vitamin D and Neurological Diseases: An Endocrine View

Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis

The Role of Selected Bioactive Compounds in the Prevention of Alzheimer’s Disease

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