Role of Vitamin D in Cognitive Dysfunction: New Molecular Concepts and Discrepancies between Animal and Human Findings

Gáll, Zsolt; Székely, Orsolya

doi:10.3390/nu13113672

Cited by 70 publications

(42 citation statements)

References 138 publications

(194 reference statements)

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“…The Association of low vitamin D levels with diet and obesity has been seen in a study done by Liel et al 18 . In another study, we have found that a high dietary supplement of vitamin D may improve depressive symptoms 19,20 . In another study Young SN suggests the main dietary source of vitamin D is fish, and while the inverse correlation between fish consumption and depression has usually been interpreted as an association between omega-3 unsaturated fats and depression, the role of vitamin D in such dietary studies requires clarification 21 .…”

Section: Discussionmentioning

confidence: 92%

Comparison of Vitamin D Level between Patients with Depressive Disorder and Apparently Healthy Individuals Attending Rajshahi Medical College Hospital

Ria¹,

Mohimen²,

Mahmuda³

et al. 2023

TAJ: J of Teachers Assoc

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Background: Vitamin D has received considerable interest from the medical community and the public because of recent evidence for the nonskeletal effects of vitamin D combined with the finding of widespread global deficiency. It has been estimated that almost 1 billion people worldwide suffer from vitamin D deficiency or insufficiency. In addition, neurobiological and neuroendocrinological substrates have been identified that indicate a link between hypovitaminosis D and several psychiatric conditions, including depression. Objectives: This study aimed to assess vitamin D level in patients with depressive disorders and to compare it with normal individuals. Materials & Methods: This cross-sectional type of comparative study was carried out in the Department of Physiology, Rajshahi Medical College, Rajshahi, in collaboration with the outpatient department of Psychiatry Rajshahi Medical College Hospital over 12 months from January 2019 to December 2019 among the Depressive patients and healthy individuals to find out and compare the vitamin D level between the two groups. Approval from the Ethical Review Committee (ERC) was obtained before the commencement of the study. A pA pre-designed, validated, structured questionnaire was used to gather information from 108 respondents by purposive sampling. Out of the 54 were newly diagnosed depressive patients, and 54 were healthy persons. In addition, a blood sample was collected to measure 25(OH)D level, and all values were analyzed statistically. Results: The Result showed a significant difference in mean plasma 25(OH)D level between the patients with depressive disorder and the healthy individuals. Circulating 25(OH)D level was found to be significantly low in the group of patients with depression. Conclusion: The present study demonstrated a significant correlation between hypovitaminosis D in patients with depressive disorders. It is suggested that possible factors such as hypovitaminosis D should be done as a routine investigation to reduce the incidence of depression. Furthermore, vitamin D supplementation might be a complementary treatment for depression. TAJ 2022; 35: No-2: 159-168

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Section: Discussionmentioning

confidence: 92%

Comparison of Vitamin D Level between Patients with Depressive Disorder and Apparently Healthy Individuals Attending Rajshahi Medical College Hospital

Ria¹,

Mohimen²,

Mahmuda³

et al. 2023

TAJ: J of Teachers Assoc

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“…There is evidence of a protective effect of high levels of vitamin D concentrations on cognitive decline, dementia, and Alzheimer's disease in older adults ( 36 , 41 , 68 , 69 ), which is consistent with our findings. The reason for this may be that vitamin D acts as a cognitive protector by controlling oxidative stress, inflammation, and energy metabolism through its own receptor VDR ( 70 , 71 ), but these findings were conducted in preclinical studies, therefore, the improvement effect of vitamin D supplementation is contradictory at this stage. As only a few randomized controlled trials (RCTs) have explored the effect of vitamin D supplementation on cognitive performance in older people, only two RCTs identified an improvement in cognitive function by vitamin D supplementation, and participants had cognitive impairment ( 69 , 72 ).…”

Section: Discussionmentioning

confidence: 99%

The role of vitamin D in the link between physical frailty and cognitive function: A mediation analysis in community-dwelling Chinese older adults

Xiong

Xue²

2022

Front. Nutr.

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BackgroundPhysical frailty and cognitive aging have important influences on poor clinical outcomes in older adults. Many studies have investigated the association between frailty and cognitive function, but whether vitamin D mediates the association between frailty and cognitive function is unclear. We explored the mediating role of vitamin D on the cross-sectional association between physical frailty and cognitive function using data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS).MethodsWe analyzed data from 1944 subjects aged 60 years and older from the 2011 CLHLS cohort. Frailty status was identified by the Osteoporotic Fracture Study (SOF) index. The Chinese version of the Mini-Mental State Examination (MMSE) was used to assess cognitive function. Linear regression models were used to examine the association between frailty, vitamin D, and cognition, adjusted for a range of covariates. Mediation analyses tested the indirect effects of vitamin D on physical frailty and cognitive function.ResultPhysical frailty was negatively associated with vitamin D levels and scores on the MMSE, and vitamin D levels were positively associated with scores on the MMSE. Linear regression analysis showed that physical frailty and serum vitamin D concentration were significant predictors of cognitive function. Importantly, mediation analysis showed that serum vitamin D concentration significantly mediated the relationship between physical frailty and cognitive function.ConclusionThe association between physical frailty and cognitive function appears to be mediated by vitamin D. Future studies should explore whether serum vitamin D concentrations may mediate the association between physical frailty and cognitive decline and whether this mediating role is moderated by other factors.

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“…We have used the PubMed/MEDLINE, EMBASE and Psych INFO databases to identify the most relevant study publications, establishing as search criteria the terms: vitamin D, cholecalciferol, Vitamin D exerts its effect through genomic and non-genomic pathways. Genomics is performed through the VDR receptor which is a member of the nuclear transcription factor family, thus influencing gene transcription and regulating the expression of more than 900 genes [6]. Due to positioning in DNA, it is also involved in the expression of numerous protein complexes throughout the body, including the brain.…”

Section: Methodsmentioning

confidence: 99%

"Vitamin D and Cognitive Function: Descriptive Review of the Scientific Evidence"

Javier¹

2022

BJSTR

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Introduction: Considerable amounts of vitamin D are found in the brain and the vitamin D receptor is widely distributed throughout various brain regions. The effects of vitamin D on the regulation of genes involved in neuroprotection and neurotropism or neuronal regeneration have been described. There is a high prevalence of vitamin D deficiency or insufficiency among the elderly. The aim of this article is to review the relationship between vitamin D and cognition. We have attempted to answer three questions: Is there a physiological rationale that allows us to conclude that vitamin D has cognitively relevant effects? Is hypovitaminosis D associated with cognitive impairment? Does vitamin D supplementation have any effect on cognitive impairment or dementia? Development: A descriptive review has been conducted on the research that we have considered to be the most relevant published in the last decade: cross-sectional, prospective, and retrospective studies, and randomized placebo-controlled trials have been included. Conclusions:Preclinical studies show wide proof of concept that vitamin D may play a relevant role in cognitive functions. There is no consensus on the association of hypovitaminosis D and cognitive impairment, although most studies have found such an association. There is also no conclusive scientific evidence on beneficial effects of vitamin D supplementation on cognitive impairment, although the positive evidence available -mainly with cholecalciferol or vitamin D3 as preferred vitamin D form-is leading many authors and some clinicians to recommend it in usual practice. on vitamin D supplementation in this context and points out

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Role of Vitamin D in Cognitive Dysfunction: New Molecular Concepts and Discrepancies between Animal and Human Findings

Cited by 70 publications

References 138 publications

Comparison of Vitamin D Level between Patients with Depressive Disorder and Apparently Healthy Individuals Attending Rajshahi Medical College Hospital

Comparison of Vitamin D Level between Patients with Depressive Disorder and Apparently Healthy Individuals Attending Rajshahi Medical College Hospital

The role of vitamin D in the link between physical frailty and cognitive function: A mediation analysis in community-dwelling Chinese older adults

"Vitamin D and Cognitive Function: Descriptive Review of the Scientific Evidence"

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