Role of vitamins in treatment of lead intoxication

Tandon, S. K.; Singh, Surendra

doi:10.1002/1520-670x(2000)13:3<305::aid-jtra8>3.0.co;2-f

Cited by 14 publications

(14 citation statements)

References 23 publications

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“…Flora and colleagues [40] identified thiamine and pyridoxine as inhibitors of lead intoxication. Thiamine enhanced the efficacy of chelating agents in mobilizing tissue lead and induced its excretion in lead-exposed animals [41]. The thiol group of thiamine may complex with lead by conformational transformation in vivo resulting into thiazole openring conformation [42,43].…”

Section: Discussionmentioning

confidence: 99%

Determinants of the Blood Lead Level of US Women of Reproductive Age

Lee

Chun

Song

2005

Journal of the American College of Nutrition

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Section: Discussionmentioning

confidence: 99%

Determinants of the Blood Lead Level of US Women of Reproductive Age

Lee

Chun

Song

2005

Journal of the American College of Nutrition

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“…The role of ascorbic acid under conditions of lead exposure has been investigated in both man and animals for several decades with contradictory results, especially concerning lead toxicokinetics. It has been suggested that ascorbic acid is a natural chelating agent capable of complexing lead by forming a poorly ionized but soluble lead compound (Flora & Tandon 1986; Tandon & Singh 2000). Back in 1940 Dannenberg et al described an unsuccessful attempt to treat with ascorbic acid a 27‐month‐old child suffering from lead encephalopathy.…”

mentioning

confidence: 99%

“…Certain animal experiments, however, also showed beneficial effects of ascorbic acid on lead metabolism and toxicity. Studies on rats have shown that ascorbic acid can decrease lead absorption (Flora & Tandon 1986), promote lead elimination (Goyer & Cherian 1979; Flora & Tandon 1986; Dhawan et al 1988; Tandon & Flora 1989; Vij et al 1998; Tandon & Singh 2000), and alleviate toxic effects of lead (Flora & Tandon 1986; Fisher et al 1998; Hsu et al 1998; Vij et al 1998; Patra et al 2001). Lower lead incorporation and reduced lead toxicity has been reported by Fisher et al (1998) in Chinese hamster peritoneal cell cultures concomitantly exposed to lead and ascorbic acid.…”

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confidence: 99%

Ascorbic Acid Supplementation Does Not Improve Efficacy of meso‐Dimercaptosuccinic Acid Treatment in Lead‐Exposed Suckling Rats

Varnai

Piasek

Blanuša

et al. 2003

Pharmacology & Toxicology

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It was suggested that ascorbic acid as a natural chelating agent can influence lead toxicokinetics and improve chelating properties of dimercaptosuccinic acid (DMSA) in adult rats. In this paper potential benefits of ascorbic acid supplementation, alone or combined with DMSA, in decreasing lead retention in suckling rats were evaluated. Such data in young mammals are not available. L-Ascorbic acid (daily dose 650 mg/kg b.wt.) and/or DMSA (daily dose 91 mg/kg b.wt.) were administered orally to suckling Wistar rats either during ongoing 8-day oral lead exposure (as acetate; daily dose 2 mg lead/kg b.wt.) or after 3-day lead exposure (total dose 12 mg lead/kg b.wt.). Lead concentrations were analysed in the carcass (skeleton), liver, kidneys and brain by atomic absorption spectrometry. By ascorbic acid supplementation lead retention was not reduced under either lead exposure condition. Lead concentration was even increased in the carcass. Treatment with DMSA under both exposure conditions significantly reduced lead in all analysed tissues. Combined treatment with ascorbic acid and DMSA during ongoing lead exposure was substantially less effective than DMSA treatment alone, and did not affect DMSA efficacy when administered after lead exposure. It was concluded that ascorbic acid administered either during or after lead exposure in suckling rats has no beneficial effect on either lead retention or DMSA chelation effectiveness.

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“…17 However, after the coating of PGA, the pH value declined to 2.4 amid the presence of abundant carboxylic acid groups. The low pH PZC of PGA-SPIONs indicated that their negative surface charges at most of the environmental pH (3-9) and biological pH (1)(2)(3)(4)(5)(6)(7)(8) should prevent aggregation and facilitate the …”

Section: Magnetic Propertymentioning

confidence: 99%

In vitro removal of toxic heavy metals by poly(γ-glutamic acid)-coated superparamagnetic nanoparticles

Inbaraj¹,

Chen²

2012

IJN

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Background: Chelation therapy involving organic chelators for treatment of heavy metal intoxication can cause cardiac arrest, kidney overload, mineral deficiency, and anemia. Methods: In this study, superparamagnetic iron oxide nanoparticles (SPIONs) modified with an edible biopolymer poly(γ-glutamic acid) (PGA) were synthesized by coprecipitation method, characterized and evaluated for their removal efficiency of heavy metals from a metal solution, and simulated gastrointestinal fluid (SGIF). Results: Instrumental characterization of bare-and PGA-SPIONs revealed 7% coating of PGA on SPIONs with a spherical shape and an iron oxide spinel structure belonging to magnetite. The particle sizes as determined from transmission electron microscopy images were 8.5 and 11.7 nm for bare-and PGA-SPIONs, respectively, while the magnetization values were 70.3 and 61.5 emu/g. Upon coating with PGA, the zeta potentials were shifted from positive to negative at most of the environmental pH (3-8) and biological pH (1-8), implying good dispersion in aqueous suspension and favorable conditions for heavy metal removal. Batch studies showed rapid removal of lead and cadmium with the kinetic rates estimated by pseudo-second-order model being 0.212 and 0.424 g/mg⋅min, respectively. A maximum removal occurred in the pH range 4-8 in deionized water and 5-8 in SGIF corresponding to most gastrointestinal pH except for the stomach. Addition of different ionic strengths (0.001-1 M sodium acetate) and essential metals (Cu, Fe, Zn, Mg, Ca, and K) did not show any marked influence on lead removal by PGASPIONs, but significantly reduced the binding of cadmium. Compared to deionized water, the lead removal from SGIF was high at all pH with the Langmuir monolayer removal capacity being 98.70 mg/g for the former and 147.71 mg/g for the latter. However, a lower cadmium removal capacity was shown for SGIF (23.15 mg/g) than for deionized water (31.13 mg/g). Conclusion: These results suggest that PGA-SPIONs could be used as a metal chelator for clinical treatment of metal poisoning.

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Role of vitamins in treatment of lead intoxication

Cited by 14 publications

References 23 publications

Determinants of the Blood Lead Level of US Women of Reproductive Age

Determinants of the Blood Lead Level of US Women of Reproductive Age

Ascorbic Acid Supplementation Does Not Improve Efficacy of meso‐Dimercaptosuccinic Acid Treatment in Lead‐Exposed Suckling Rats

In vitro removal of toxic heavy metals by poly(γ-glutamic acid)-coated superparamagnetic nanoparticles

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Role of vitamins in treatment of lead intoxication

Cited by 14 publications

References 23 publications

Determinants of the Blood Lead Level of US Women of Reproductive Age

Determinants of the Blood Lead Level of US Women of Reproductive Age

Ascorbic Acid Supplementation Does Not Improve Efficacy of meso‐Dimercaptosuccinic Acid Treatment in Lead‐Exposed Suckling Rats

In vitro removal of toxic heavy metals by poly(&gamma;-glutamic acid)-coated superparamagnetic nanoparticles

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In vitro removal of toxic heavy metals by poly(γ-glutamic acid)-coated superparamagnetic nanoparticles