2006
DOI: 10.1128/aac.00356-06
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Role of VraSR in Antibiotic Resistance and Antibiotic-Induced Stress Response in Staphylococcus aureus

Abstract: Exposure of Staphylococcus aureus to cell wall inhibitors induces massive overexpression of a number of genes, provided that the VraSR two-component sensory regulatory system is intact. Inactivation of vraS blocks this transcriptional response and also causes a drastic reduction in the levels of resistance to beta-lactam antibiotics and vancomycin. We used an experimental system in which the essential cell wall synthesis gene of S. aureus, pbpB, was put under the control of an isopropyl-␤-D-thiogalactopyranosi… Show more

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Cited by 168 publications
(186 citation statements)
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“…A LiaRS homologue, the VraSR system of Staphylococcus aureus, has also been reported to contribute to antibiotic resistance in clinical isolates of Staph. aureus (Boyle-Vavra et al, 2006;Gardete et al, 2006;Kuroda et al, 2003Kuroda et al, , 2000. Other than the cell wall stress responses, LiaS (formerly designated HK11) has been found to play a role in acid resistance; it may act as a pH sensor (Li et al, 2002) and regulate virulence factor expression in Streptococcus mutans (Chong et al, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…A LiaRS homologue, the VraSR system of Staphylococcus aureus, has also been reported to contribute to antibiotic resistance in clinical isolates of Staph. aureus (Boyle-Vavra et al, 2006;Gardete et al, 2006;Kuroda et al, 2003Kuroda et al, , 2000. Other than the cell wall stress responses, LiaS (formerly designated HK11) has been found to play a role in acid resistance; it may act as a pH sensor (Li et al, 2002) and regulate virulence factor expression in Streptococcus mutans (Chong et al, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…A number of these genes are controlled by the VraSR two-component regulatory system (Kuroda et al, 2003). Inactivation of VraSR results in reduced oxacillin MICs in meticillin-resistant S. aureus (BoyleVavra et al, 2006;Gardete et al, 2006). VraSR has been proposed to be a sentinel sensing perturbations in peptidoglycan biosynthesis, functioning to control the expression of genes involved in generation of a resistance phenotype.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, a core and accessory set of cell wall-associated genes (the "cell wall stimulon") has been described based on the results of microarray transcriptional analysis experiments after the exposure of S. aureus to cell wall-active agents (92,168,329,361). These genes are predominately under the control of the two-component regulatory (2CR) system vraSR.…”
Section: Understanding Vancomycin Resistance: the Staphylococcal Cellmentioning
confidence: 99%