Role of white matter in cognitive impairment among relapsing remitting multiple sclerosis patients

Elkhooly, Mahmoud; Bao, Fen; Raghib, Muhammad; Millis, Scott; Bernitsas, Evanthia

doi:10.1016/j.msard.2023.105030

Cited by 6 publications

(2 citation statements)

References 55 publications

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“…Previous studies have explored the role of WM and reported a contribution from WM to MS-related cognitive impairment. 53,54 This is also in line with a previous study demonstrating diminished medullary vein visibility in periventricular WM territories in MS patients. 55 Taken together, the findings of this study emphasize the utility of deep cerebral venous susceptibility as a potential imaging biomarker of cognitive decline in RRMS as well as normal aging and other neurodegenerative disorders.…”

Section: Discussionsupporting

confidence: 91%

Reduced Oxygen Extraction Fraction in Deep Cerebral Veins Associated with Cognitive Impairment in Multiple Sclerosis

Sawan,

Li,

Buch

et al. 2024

Preprint

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Studying the relationship between cerebral oxygen utilization and cognitive impairment is essential to understanding neuronal functional changes in the disease progression of multiple sclerosis (MS). This study explores the potential of using venous susceptibility in internal cerebral veins (ICVs) as an imaging biomarker for cognitive impairment in relapsing-remitting MS (RRMS) patients. Quantitative susceptibility mapping derived from fully flow-compensated MRI phase data was employed to directly measure venous blood oxygen saturation levels (SvO2) in the ICVs. Results revealed a significant reduction in the susceptibility of ICVs (212.4 ± 30.8 ppb vs 239.4 ± 25.9 ppb) and a significant increase of SvO2 (74.5 ± 1.89 % vs 72.4 ± 2.23 %) in patients with RRMS compared with age- and sex-matched healthy controls. Both the susceptibility of ICVs (r = 0.646, p = 0.004) and the SvO2 (r = -0.603, p = 0.008) exhibited a strong correlation with cognitive decline in these patients assessed by the Paced Auditory Serial Addition Test, while no significant correlation was observed with clinical disability measured by the Expanded Disability Status Scale. The findings suggest that venous susceptibility in ICVs has the potential to serve as a specific indicator of oxygen metabolism and cognitive function in RRMS.

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Section: Discussionsupporting

confidence: 91%

Reduced Oxygen Extraction Fraction in Deep Cerebral Veins Associated with Cognitive Impairment in Multiple Sclerosis

Sawan,

Li,

Buch

et al. 2024

Preprint

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“… 30 Another specific tract involved in speech is the arcuate fasciculus, 33-35 which connects BA44/BA45 and BA22, regions involved in speech preparation, production and comprehension. 34-37 While arcuate fasciculus damage has been recorded in multiple sclerosis, this has been relative to cognitive decline 38 , 39 and depression 40 rather than speech. Finally, damage to the cerebello-thalamo-cortical (CTC) tracts is linked to worse motor performance in persons with multiple sclerosis.…”

Section: Introductionmentioning

confidence: 99%

Volumetric and diffusion MRI abnormalities associated with dysarthria in multiple sclerosis

Kenyon,

Strik,

Noffs

et al. 2024

Brain Communications

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Up to half of all people with multiple sclerosis experience communication difficulties due to dysarthria, a disorder that impacts the motor aspects of speech production. Dysarthria in multiple sclerosis is linked to cerebellar dysfunction, disease severity and lesion load, but the neuroanatomical substrates of these symptoms remain unclear. In this study, 52 participants with multiple sclerosis and 14 age- and sex-matched healthy controls underwent structural and diffusion MRI, clinical assessment of disease severity and cerebellar dysfunction, and a battery of motor speech tasks. Assessments of regional brain volume and white matter integrity, and their relationships with clinical and speech measures, were undertaken. White matter tracts of interest included the interhemispheric sensorimotor tract, cerebello-thalamo-cortical tract, and arcuate fasciculus, based on their roles in motor and speech behaviours. Volumetric analyses were targeted to Broca’s area, Wernicke’s area, the corpus callosum, thalamus, and cerebellum. Our results indicated that multiple sclerosis participants scored worse on all motor speech tasks. Fixel-based diffusion MRI analyses showed significant evidence of white matter tract atrophy in each tract of interest. Correlational analyses further indicated that higher speech naturalness - a perceptual measure of dysarthria – and lower reading rate were associated with axonal damage in the interhemispheric sensorimotor tract and left arcuate fasciculus in people with multiple sclerosis. Axonal damage in all tracts of interest also correlated with clinical scales sensitive to cerebellar dysfunction. Participants with multiple sclerosis had lower volumes of the thalamus and corpus callosum compared to controls, though no brain volumetrics correlated with measures of dysarthria. These findings indicate that axonal damage, particularly when measured using diffusion metrics, underpin dysarthria in multiple sclerosis.

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Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms

Jellinger

2024

J Neural Transm

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Role of white matter in cognitive impairment among relapsing remitting multiple sclerosis patients

Cited by 6 publications

References 55 publications

Reduced Oxygen Extraction Fraction in Deep Cerebral Veins Associated with Cognitive Impairment in Multiple Sclerosis

Reduced Oxygen Extraction Fraction in Deep Cerebral Veins Associated with Cognitive Impairment in Multiple Sclerosis

Volumetric and diffusion MRI abnormalities associated with dysarthria in multiple sclerosis

Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms

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