Role of whole brain radiotherapy in the management of infratentorial metastases from lung and breast cancer

Cacho-Díaz, Bernardo; Alvarez-Alvarez, Alejandra; Salmerón-Moreno, Karen; Rodríguez-Mayoral, Oscar; Santiago-Concha, Bernardino Gabriel; Rodriguez, Oscar Gerardo Arrieta

doi:10.5603/rpor.a2021.0060

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…In these patients, fractionation of 4 Gy into 5 sessions did not improve on survival or QoL achieved with optimal supportive care [ 11 ]. WBRT still is indicated in patients with a good general health and multiple brain metastases, and be is equally effective in those with supraor infratentorial locations [ 12 ]. The standard dose is 30 Gy delivered in 10 fractions of 3 Gy, as studies testing dose escalation failed to improve the results of this scheme [ 13 , 14 ].…”

Section: Radiotherapy Treatmentmentioning

confidence: 99%

Brain metastases from non-small cell lung carcinoma: an overview of classical and novel treatment strategies

Martín

Hernánz

Vallejo

et al. 2022

Rep Pract Oncol Radiother.

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Section: Radiotherapy Treatmentmentioning

confidence: 99%

Brain metastases from non-small cell lung carcinoma: an overview of classical and novel treatment strategies

Martín

Hernánz

Vallejo

et al. 2022

Rep Pract Oncol Radiother.

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Survival in patients with surgically treated brain metastases: does infratentorial location matter?

et al. 2023

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Surgical resection is a common treatment modality for brain metastasis (BM). Location of the BM might significantly impact patient survival and therefore might be considered in clinical decision making and patient counseling. In the present study, the authors analyzed infra- and supratentorial BM location for a potential prognostic difference. Between 2013 and 2019, 245 patients with solitary BM received BM resection at the authors’ neuro-oncological center. In order to produce a covariate balance for commonly-known prognostic variables (tumor entity, age, preoperative Karnofsky Performance Score, and preoperative Charlson Comorbidity Index), a propensity score matching at a ratio of 1:1 between the cohort of patients with infra- and supratentorial BM location was performed using R. Overall survival (OS) rates were assessed for both matched cohorts of patients with BM. Sixty-one of 245 patients (25%) with solitary BM exhibited an infratentorial tumor location; 184 patients (75%) suffered from supratentorial solitary BM. Patients with infratentorial BM revealed a median OS of 11 months (95% confidence interval (CI) 7.4–14.6 months). Compared with this, median OS for the group of 61 individually matched patients with solitary supratentorial solitary BM was 13 months (95% CI 10.9-15.1 months) (p = 0.32). The present study suggests that the prognostic value of infra- and supratentorial BMs does not significantly differ in patients that undergo surgery for solitary BM. These results might encourage physicians to induce surgical therapy of supra- and infratentorial BM in a similar manner.

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Role of whole brain radiotherapy in the management of infratentorial metastases from lung and breast cancer

Abstract: Background: Brain metastases (BM) occur in almost one third of patients with systemic malignancies. Only a small number of studies focus on infratentorial location and whole brain radiotherapy (WBRT) as the main non-surgical management.

Cited by 2 publications

References 13 publications

Brain metastases from non-small cell lung carcinoma: an overview of classical and novel treatment strategies

Brain metastases from non-small cell lung carcinoma: an overview of classical and novel treatment strategies

Survival in patients with surgically treated brain metastases: does infratentorial location matter?

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