Role of zinc and copper ions in the pathogenetic mechanisms of Alzheimer’s and Parkinson’s diseases

Stelmashook, E. V.; Isaev, N. K.; Генрихс, Е. Е.; Amelkina, G. A.; Хаспеков, Л. Г.; Skrebitsky, V. G.; Иллариошкин, С. Н.

doi:10.1134/s0006297914050022

Cited by 83 publications

(44 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, Zn deficiency may result in increased oxidative stress, which leads to nigral cell death in PD 26 . This idea is supported by the findings that the levels of nitric oxide and lipid peroxidation products are high and the Zn levels are low in the blood plasma of PD patients 17, 26 . In addition, Zn is required for maintaining the conformation of Parkin, and Parkin dysfunction can cause PD.…”

Section: Discussionmentioning

confidence: 76%

“…Since removal of Zn from Parkin can cause unfolding of the protein, Zn deficiency may contribute to the progression of PD by inducing Parkin dysfunction 22 . Interestingly, in the Drosophila disease model with a defective Parkin protein, Zn-supplemented food intake resulted in an extended lifespan and an improvement of motoric abilities 17, 48 . Although no clinical reports have shown the effectiveness of Zn therapy in patients with PD, Zn therapy has been proven to favor improvement and even resolution of neurological damage in patients with Wilson’s disease 49 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study

Liu

Zhong

et al. 2017

Sci Rep

View full text Add to dashboard Cite

There is no consensus on the involvement of zinc (Zn) dysfunctions in Parkinson’s Disease (PD). We performed a meta-analysis to evaluate whether circulating Zn levels in the serum, plasma, and cerebrospinal fluid (CSF) are altered in PD. Twenty-three published studies were selected by searching the databases of PubMed and China National Knowledge Infrastructure (CNKI). A total of 803 PD patients and 796 controls, 342 PD patients and 392 controls, and 135 PD patients and 93 controls were included to study Zn levels in the serum, plasma, and CSF, respectively. Our meta-analysis showed that the serum Zn levels were significantly lower in PD patients compared with health controls (SMD = −0.59; 95% CI [−1.06, −0.12]; P = 0.014). A reduced Zn levels in PD patients were found when serum and plasma studies were analyzed together (SMD = −0.60, 95% CI [−0.98; −0.22]; p = 0.002). PD patients had a tendency toward reduced CSF Zn levels compared with health controls (SMD = −0.50; 95% CI [−1.76, 0.76]; P = 0.439), but no statistical significance was obtained and this data did not allow conclusions due to a small sample size of CSF studies. This study suggests that reduced Zn levels in the serum and plasma are associated with an increased risk for PD.

show abstract

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study

Liu

Zhong

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…BAF's mineral composition is relevant, since zinc is especially important for normal nervous system activity (Stelmashook et al, 2014). The low sodium content of baru almond and BAF (Table 3) can be considered similar to that of in natura BAF.…”

Section: Resultsmentioning

confidence: 97%

Nutritional quality and bioactive compounds of partially defatted baru almond flour

Siqueira¹,

Pacheco²,

Naves³

2015

Food Sci. Technol (Campinas)

View full text Add to dashboard Cite

This study aimed to investigate the nutritional quality and bioactive potential of partially defatted baru (Dipteryx alataVog.) almond flour (BAF). The flour's proximate and mineral compositions, total phenolic, tocopherols and carotenoids contents, antioxidant capacity, trypsin inhibitor and amino acid analyses were performed. An experiment was conducted with 24 male Wistar rats in order to evaluate the flour's protein quality. BAF has high protein, fiber and mineral contents (iron, zinc, magnesium and copper), and it is a source of calcium. BAF presented relevant amounts of total phenolics (625 mg/100g) and good antioxidant capacity (130 µmol/Trolox eq). Autoclaved BAF showed essential amino acids profile, digestibility and protein quality better than in natura BAF. Autoclaved BAF might be used for human consumption as a source of quality protein and bioactive compounds, in healthy diets and processed foods.Keywords: baru seed; protein; chemical composition; amino acids; antioxidants.Practical Application: Defatted baru almond flour is a bioactive compound-rich raw material for healthy and innovative foods.

show abstract

“…In work an increased level of copper was shown in blood serum of patients with AD. Moreover it was found that copper level was significantly increased in cerebrospinal fluid [6].…”

Section: Introductionmentioning

confidence: 98%

Establishment of a New Rat Model of Alzheimer

2016

IJSR

View full text Add to dashboard Cite

Copper is of great importance for the normal brain. Excess of copper results in neurodegenerative diseases such asAlzheimer's disease (AD). The pathological hallmarks of AD are the amyloid-β (Aβ) peptides. Aβ peptides have been shown to bind copper with high affinity. We established a new rat model of AD by using copper sulfate (CuSO 4 ) solution with several doses and for different periods of time. The rats were randomly divided into normal control groups and AD groups. All rats underwent behavioral, histopathological and biochemical evaluations. The results of behavioral test revealed a significant improvement in the normal control groups. Conversely, AD groups showed impairments in the cognitive function as well as spatial memory with several degrees according to the duration and dose of CuSO 4 administration. The precise dose of CuSO 4 that showed the most cognitive deficits was 6 mg/L for eight weeks. Histochemistry staining revealed neuronal abnormalities in the brain sections of AD groups with several degrees. Biochemical analysis demonstrated that the level of γ-secretase was highest at a dose 6 mg/L CuSO 4 for eight weeks, conversely, the level of α-secretase was lowest at the same dose. We conclude that copper appeared to have a role in the formation of senile plaques, the hall mark of AD. According to these issues, we established a new rat model of AD using CuSO 4 solution.

show abstract

Role of zinc and copper ions in the pathogenetic mechanisms of Alzheimer’s and Parkinson’s diseases

Cited by 83 publications

References 67 publications

Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study

Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study

Nutritional quality and bioactive compounds of partially defatted baru almond flour

Establishment of a New Rat Model of Alzheimer

Contact Info

Product

Resources

About