Role of Zinc and Selenium in Oxidative Stress and Immunosenescence: Implications for Healthy Aging and Longevity

Mocchegiani, Eugenio; Malavolta, Marco

doi:10.1007/978-3-319-99375-1_66

Cited by 7 publications

(6 citation statements)

References 231 publications

(249 reference statements)

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“…Apart from being a cofactor for numerous enzymes, they play the key role in the development and functioning of the central nervous system [ 24 , 25 , 26 ]. Disturbed homeostasis and distribution of TEs related to anti-oxidant, anti-inflammatory, and apoptotic effects seem to be connected with neurodegenerative diseases and aging [ 27 ]. Disturbances in Cu homeostasis lead to impaired neuronal function and neurological diseases, including Alzheimer’s disease and Wilson’s disease [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland—A New Insight into Stroke Pathophysiology

et al. 2021

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Background: In recent years, trace elements (TEs) have gained considerable attention in the course of treatment and diagnosis of ischemic stroke. The purpose of the conducted research was to determine the trace mineral status (Se, Cu, Zn, Cu/Zn ratio, and Cu/Se ratio) in patients with acute ischemic stroke compared to the population of healthy people in the northeastern region of Poland. Materials and methods: 141 patients with acute ischemic stroke (AIS) and 69 healthy control subjects were examined. The serum concentrations of mineral components were assessed by the atomic absorption spectrometry method. Clinical parameters were updated based on medical records. Results: The serum Se and Zn concentrations were significantly decreased (p < 0.0001; p < 0.0001) in patients with AIS compared with healthy control subjects. However, no significant differences were revealed in terms of the serum Cu concentration (p = 0.283). As expected, we found that the serum Cu/Zn and Cu/Se molar ratios were significantly higher (p = 0.001; p < 0.0001) in patients with AIS compared with healthy control subjects. Conclusions: Disturbed metal homeostasis is a significant contributor to AIS pathogenesis. Furthermore, marked disruption of the serum Cu/Zn and Cu/Se molar ratios could serve as a valuable indicator of AIS patients’ nutritional status and oxidative stress levels.

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Section: Introductionmentioning

confidence: 99%

Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland—A New Insight into Stroke Pathophysiology

et al. 2021

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“…An investigation carried out by Zhang et al [8] showed that the levels of environmental Se were very low, and Kaschin-Beck disease in the Tibetan Plateau was much severe with decreasing environmental Se under the Se-deficient condition, suggesting the relationship between Kaschin-Beck disease and Se deficiency in the Tibetan Plateau. In addition, Se is related to other human diseases and health, such as cancer [10][11][12][13], muscle disease [14], and healthy aging and longevity [15][16][17]. Therefore, it is essential to maintain Se homeostasis in human body [18,19].…”

Section: Introductionmentioning

confidence: 99%

Selenium Biofortification of Crop Food by Beneficial Microorganisms

et al. 2020

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Selenium (Se) is essential for human health, however, Se is deficient in soil in many places all around the world, resulting in human diseases, such as notorious Keshan disease and Keshin–Beck disease. Therefore, Se biofortification is a popular approach to improve Se uptake and maintain human health. Beneficial microorganisms, including mycorrhizal and root endophytic fungi, dark septate fungi, and plant growth-promoting rhizobacteria (PGPRs), show multiple functions, especially increased plant nutrition uptake, growth and yield, and resistance to abiotic stresses. Such functions can be used for Se biofortification and increased growth and yield under drought and salt stress. The present review summarizes the use of mycorrhizal fungi and PGPRs in Se biofortification, aiming to improving their practical use.

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“…Similar to SCFA, selenium protects DNA, and it has been suggested that Se slows the aging process by protecting DNA against reactive oxygen species [ 91 ]. Both postbiotics and minerals such as selenium and zinc exhibited antioxidant activities [ 92 ].…”

Section: Mineral-enriched Postbiotics and Their Applications In Micro...mentioning

confidence: 99%

Mineral-Enriched Postbiotics: A New Perspective for Microbial Therapy to Prevent and Treat Gut Dysbiosis

et al. 2022

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Postbiotics are non-viable probiotic preparations that confer a health benefit on the host. In the last years, scientific literature has proved that postbiotics have health-promoting features and technological advantages compared to probiotics, augmenting their full potential application in the food and pharmaceutical industries. The current work comprehensively summarizes the benefits and potential applications of postbiotics and essential mineral-enriched biomass and proposes a new strategy for microbial therapy—mineral-enriched postbiotics. We hypothesize and critically review the relationship between micronutrients (calcium, magnesium, iron, zinc, selenium) and postbiotics with gut microbiota, which has been barely explored yet, and how the new approach could be involved in the gut microbiome modulation to prevent and treat gut dysbiosis. Additionally, the bioactive molecules and minerals from postbiotics could influence the host mineral status, directly or through gut microbiota, which increases the mineral bioavailability. The review increases our understanding of the health improvements of mineral-enriched postbiotics, including antioxidant functions, highlighting their perspective on microbial therapy to prevent and threaten gut-related diseases.

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Role of Zinc and Selenium in Oxidative Stress and Immunosenescence: Implications for Healthy Aging and Longevity

Cited by 7 publications

References 231 publications

Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland—A New Insight into Stroke Pathophysiology

Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland—A New Insight into Stroke Pathophysiology

Selenium Biofortification of Crop Food by Beneficial Microorganisms

Mineral-Enriched Postbiotics: A New Perspective for Microbial Therapy to Prevent and Treat Gut Dysbiosis

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