Role of zinc in regulation of arterial blood pressure and in the etiopathogenesis of arterial hypertension

Tubek, Sławomir

doi:10.1007/bf02698082

Cited by 74 publications

(51 citation statements)

References 65 publications

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“…10,25 A dose-dependent rise of plasma rennin activity and serum aldosterone levels, without significant changes in blood pressure, was observed in normotensive individuals undergoing additional zinc supplementation. 26 We did not observe any significant change in blood pressure, a finding which is in line with a study among diabetic patients with microalbuminuria. 16 The main limitation of the present study might be its short time of follow-up, since it is probable that changes in some anthropometric measures and cardiometabolic risk factors could reach significance with longer follow-up.…”

Section: Discussionsupporting

confidence: 79%

Effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children

Hashemipour¹,

Kelishadi²,

Shapouri³

et al. 2009

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OBJECTIVE: Zinc, an essential trace element and a component of many enzymes, is involved in the synthesis, storage and release of insulin. The aim of the present study was to assess the effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children. DESIGN: This triple-masked, randomized, placebocontrolled cross-over trial was conducted among 60 obese Iranian children in 2008. Pertinent clinical findings, fasting serum glucose, insulin and lipid profile were assessed. Participants were randomly assigned to two groups of equal number; one group received 20mg elemental zinc and the other group received placebo on a regular daily basis for eight weeks. After a 4-week wash-out period, the groups were crossed over. RESULTS: The mean age of participants was 9.1 ± 1.1 years. After receiving zinc, the mean fasting plasma glucose (FPG), insulin and HOMA-IR decreased significantly, while body mass index (BMI), waist circumference (WC), LDL-C and triglycerides (TG) did not significantly change. After receiving placebo, the mean FPG, insulin and HOMA-IR increased significantly, while BMI, WC, LDL-C and TG showed a non-significant increase. CONCLUSION: Besides lifestyle modification, zinc supplementation might be considered as a useful and safe additional intervention treatment for improvement of cardiometabolic risk factors related to childhood obesity.

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Section: Discussionsupporting

confidence: 79%

Effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children

Hashemipour¹,

Kelishadi²,

Shapouri³

et al. 2009

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“…The BMI-associated variant rs13107325 is a non-synonymous SNP located in exon 7 [34] of the SLC39A8 gene, which encodes a zinc transporter involved in zinc transportation into the cell at the onset of inflammation [35,36]. As indicated recently, zinc deficiency is also associated with lower BP [37]. Third, the associations of the WHR-increasing allele at GRB14 with metabolically 'unhealthy' phenotypes (higher proinsulin and lower HDL-cholesterol) have been confirmed in the most recent meta-analyses for glycaemic traits (the Meta-Analyses of Glucose and Insulin-related traits Consortium [MAGIC]) [30] and type 2 diabetes (the DIAbetes Genetics Replication And Meta-analysis [DIAGRAM] consortium) [31], and in a GWAS for HDL-cholesterol [38].…”

Section: Discussionmentioning

confidence: 99%

Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals

et al. 2013

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Aims/hypothesis Genetic pleiotropy may contribute to the clustering of obesity and metabolic conditions. We assessed whether genetic variants that are robustly associated with BMI and waist-to-hip ratio (WHR) also influence metabolic and cardiovascular traits, independently of obesity-related traits, in meta-analyses of up to 37,874 individuals from six European population-based studies. Methods We examined associations of 32 BMI and 14 WHR loci, individually and combined in two genetic predisposition scores (GPSs), with glycaemic traits, blood lipids and BP, with and without adjusting for BMI and/or WHR. Results We observed significant associations of BMIincreasing alleles at five BMI loci with lower levels of 2 h glucose (RBJ [also known as DNAJC27], QPTCL: effect sizes −0.068 and −0.107 SD, respectively), HDL-cholesterol (SLC39A8: −0.065 SD, MTCH2: −0.039 SD), and diastolic BP (SLC39A8: −0.069 SD), and higher and lower levels of LDL-and total cholesterol (QPTCL: 0.041 and 0.042 SDs, respectively, FLJ35779 [also known as POC5]: −0.042 and −0.041 SDs, respectively) (all p<2.4×10 −4 ), independent of BMI. The WHR-increasing alleles at two WHR loci were significantly associated with higher proinsulin (GRB14: 0.069 SD) and lower fasting glucose levels (CPEB4: −0.049 SD), independent of BMI and WHR. A higher GPS-BMI was associated with lower systolic BP (−0.005 SD), diastolic BP (−0.006 SD) and 2 h glucose (−0.013 SD), while a higher GPS-WHR was associated with lower HDL-cholesterol Electronic supplementary material The online version of this article (doi:10.1007/s00125-013-2985-y) contains peer-reviewed but unedited supplementary material, which is available to authorised users. J. V. van Vliet-Ostaptchouk : M. M. van der Klauw :

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“…Zinc is one of the essential dietary factors and physiological element. A decline of zinc level can contribute to metabolic diseases, high blood pressure or diminished immune response (Tubek, 2007, Maggini et al, 2007. Vayenas et al (1998) examined changes in the concentration of zinc, manganese, and copper in the liver, spleen, and brain of rats after an iron overload by atomic absorption spectrophotometry.…”

Section: Discussionmentioning

confidence: 99%

Iron-rich complexes in human spleen in hereditary spherocytosis

Bíró¹,

Busikova²,

Fujerikova³

et al. 2012

BLL

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Abstract:Objective: Tissue iron plays an important role in the development of certain diseases. Although it is one of biogenic elements, its excess induces the reactive oxygen species (ROS) formation. The aim of the present work is to examine the protection against free or loosely bound iron from the view of morphology and chemical composition of iron-rich complexes in human spleen tissues with hereditary spherocytosis (HS) by scanning and transmission electron microscope with energy-dispersive microanalysis (EDX).Results: The examination of human spleen tissues by scanning and transmission electron microscope showed covering of iron-rich particles. EDX revealed many iron-rich complexes of multi-element composition in HS samples with sulphur and phosphorus as the major elements. Detection was negative in the reference samples. Conclusion:The covering of iron-rich particles can be explained by elimination and isolation of ferritin/iron complexes from surrounding environment to prevent the ROS formation. Sulphur, phosphorus and their compounds are probably the most signifi cant elements that infl uence the ROS formation (Fig. 5, Ref. 16). Full Text in PDF www.elis.sk.

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Role of zinc in regulation of arterial blood pressure and in the etiopathogenesis of arterial hypertension

Cited by 74 publications

References 65 publications

Effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children

Effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children

Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals

Iron-rich complexes in human spleen in hereditary spherocytosis

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