Role of Zinc Supplementation on Ischemia/Reperfusion Injury in Various Organs

Akbari, Ghaidafeh

doi:10.1007/s12011-019-01892-3

Cited by 46 publications

(23 citation statements)

References 91 publications

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“…Nrf2, as an extensively studied gene, was demonstrated to play key roles in oxidative damage related disease including renal IRI. [26][27][28] Besides, several previously studies had already confirmed that Nrf2 was a potential target of miR-144-3p. 29,30 However, the potential relationship Nrf2 is a modular protein with seven Nrf2-ECH homology domains (Neh1-7), each of which fulfills distinct functions 31 and the transcriptional activity and spatial distribution of Nrf2 have a greater impact on its function.…”

Section: Discussionmentioning

confidence: 91%

LncRNA TUG1 attenuates ischaemia‐reperfusion‐induced apoptosis of renal tubular epithelial cells by sponging miR‐144‐3p via targeting Nrf2

Zhao

et al. 2021

J Cellular Molecular Medi

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Renal ischaemia-reperfusion injury (IRI), as a common type of clinical acute kidney injury (AKI), causes injury to the kidney and can even result in acute renal failure (ARF). 1,2 Convincing evidence has revealed the molecular and pathological events in AKI. [3][4][5] Oxidative stress plays a vital role in renal IRI-induced cell apoptosis and is the result of the imbalance between oxidative and antioxidant systems. 6,7 The production of excessive ROS eventually cause membrane lipid peroxidation and oxidative damage to proteins and DNA and lead to apoptosis and necrosis. 8MicroRNAs (miRNAs), small noncoding RNAs (ncRNAs), can regulate gene expression by targeting corresponding mRNAs. In

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Section: Discussionmentioning

confidence: 91%

LncRNA TUG1 attenuates ischaemia‐reperfusion‐induced apoptosis of renal tubular epithelial cells by sponging miR‐144‐3p via targeting Nrf2

Zhao

et al. 2021

J Cellular Molecular Medi

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“…Zinc is an essential trace element in the human body and plays an extremely crucial role in human growth and development. Zinc supplementation can protect against MIRI in rats, and lithium supplementation can significantly reduce the area of MI and protect against the adverse symptoms of MI [ 90 , 176 ]. However, a determination of the therapeutic effect of zinc and lithium ion on CCVD requires more clinical data.…”

Section: Clinical Prospects Of Targeting Nrf2 For Preventing Ccvdmentioning

confidence: 99%

Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease

Cheng

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Cardiocerebral vascular disease (CCVD) is a common disease with high morbidity, disability, and mortality. Oxidative stress (OS) is closely related to the progression of CCVD. Abnormal redox regulation leads to OS and overproduction of reactive oxygen species (ROS), which can cause biomolecular and cellular damage. The Nrf2/antioxidant response element (ARE) signaling pathway is one of the most important defense systems against exogenous and endogenous OS injury, and Nrf2 is regarded as a vital pharmacological target. The complexity of the CCVD pathological process and the current difficulties in conducting clinical trials have hindered the development of therapeutic drugs. Furthermore, little is known about the role of the Nrf2/ARE signaling pathway in CCVD. Clarifying the role of the Nrf2/ARE signaling pathway in CCVD can provide new ideas for drug design. This review details the recent advancements in the regulation of the Nrf2/ARE system and its role and activators in common CCVD development.

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“…Renal ischemia reperfusion injury (IRI) is a leading cause of acute kidney injury in native and transplanted kidneys. IRI contributes to adverse kidney events, including chronic kidney disease and renal fibrosis [1][2][3][4][5][6][7] . However, the underlying mechanism associated with renal IRI has not been fully elucidated, and an effective treatment for IRI does not exist.…”

Section: Introductionmentioning

confidence: 99%